All Publications


  • The cost of illness attributable to diabetic foot and cost-effectiveness of secondary prevention in Peru. BMC health services research Cárdenas, M. K., Mirelman, A. J., Galvin, C. J., Lazo-Porras, M., Pinto, M., Miranda, J. J., Gilman, R. H. 2015; 15 (1): 483-?

    View details for DOI 10.1186/s12913-015-1141-4

    View details for PubMedID 26503154

  • Complex Chemical Reaction Networks from Heuristics-Aided Quantum Chemistry JOURNAL OF CHEMICAL THEORY AND COMPUTATION Rappoport, D., Galvin, C. J., Zubarev, D. Y., Aspuru-Guzik, A. 2014; 10 (3): 897-907

    View details for DOI 10.1021/ct401004r

    View details for Web of Science ID 000332913500002

  • A metal-free organic-inorganic aqueous flow battery NATURE Huskinson, B., Marshak, M. P., Suh, C., Er, S., Gerhardt, M. R., Galvin, C. J., Chen, X., Aspuru-Guzik, A., Gordon, R. G., Aziz, M. J. 2014; 505 (7482): 195-?

    Abstract

    As the fraction of electricity generation from intermittent renewable sources--such as solar or wind--grows, the ability to store large amounts of electrical energy is of increasing importance. Solid-electrode batteries maintain discharge at peak power for far too short a time to fully regulate wind or solar power output. In contrast, flow batteries can independently scale the power (electrode area) and energy (arbitrarily large storage volume) components of the system by maintaining all of the electro-active species in fluid form. Wide-scale utilization of flow batteries is, however, limited by the abundance and cost of these materials, particularly those using redox-active metals and precious-metal electrocatalysts. Here we describe a class of energy storage materials that exploits the favourable chemical and electrochemical properties of a family of molecules known as quinones. The example we demonstrate is a metal-free flow battery based on the redox chemistry of 9,10-anthraquinone-2,7-disulphonic acid (AQDS). AQDS undergoes extremely rapid and reversible two-electron two-proton reduction on a glassy carbon electrode in sulphuric acid. An aqueous flow battery with inexpensive carbon electrodes, combining the quinone/hydroquinone couple with the Br2/Br(-) redox couple, yields a peak galvanic power density exceeding 0.6 W cm(-2) at 1.3 A cm(-2). Cycling of this quinone-bromide flow battery showed >99 per cent storage capacity retention per cycle. The organic anthraquinone species can be synthesized from inexpensive commodity chemicals. This organic approach permits tuning of important properties such as the reduction potential and solubility by adding functional groups: for example, we demonstrate that the addition of two hydroxy groups to AQDS increases the open circuit potential of the cell by 11% and we describe a pathway for further increases in cell voltage. The use of π-aromatic redox-active organic molecules instead of redox-active metals represents a new and promising direction for realizing massive electrical energy storage at greatly reduced cost.

    View details for DOI 10.1038/nature12909

    View details for Web of Science ID 000329441500034

    View details for PubMedID 24402280

  • Alzheimer's-Related Peptide Amyloid-beta Plays a Conserved Role in Angiogenesis PLOS ONE Cameron, D. J., Galvin, C., Alkam, T., Sidhu, H., Ellison, J., Luna, S., Ethell, D. W. 2012; 7 (7)

    Abstract

    Alzheimer's disease research has been at an impasse in recent years with lingering questions about the involvement of Amyloid-β (Aβ). Early versions of the amyloid hypothesis considered Aβ something of an undesirable byproduct of APP processing that wreaks havoc on the human neocortex, yet evolutionary conservation--over three hundred million years--indicates this peptide plays an important biological role in survival and reproductive fitness. Here we describe how Aβ regulates blood vessel branching in tissues as varied as human umbilical vein and zebrafish hindbrain. High physiological concentrations of Aβ monomer induced angiogenesis by a conserved mechanism that blocks γ-secretase processing of a Notch intermediate, NEXT, and reduces the expression of downstream Notch target genes. Our findings allude to an integration of signaling pathways that utilize γ-secretase activity, which may have significant implications for our understanding of Alzheimer's pathogenesis vis-à-vis vascular changes that set the stage for ensuing neurodegeneration.

    View details for DOI 10.1371/journal.pone.0039598

    View details for Web of Science ID 000306354700013

    View details for PubMedID 22792182

    View details for PubMedCentralID PMC3392248