All Publications

  • 3D-Printed Microarray Patches for Transdermal Applications. JACS Au Rajesh, N. U., Coates, I., Driskill, M. M., Dulay, M. T., Hsiao, K., Ilyin, D., Jacobson, G. B., Kwak, J. W., Lawrence, M., Perry, J., Shea, C. O., Tian, S., DeSimone, J. M. 2022; 2 (11): 2426-2445


    The intradermal (ID) space has been actively explored as a means for drug delivery and diagnostics that is minimally invasive. Microneedles or microneedle patches or microarray patches (MAPs) are comprised of a series of micrometer-sized projections that can painlessly puncture the skin and access the epidermal/dermal layer. MAPs have failed to reach their full potential because many of these platforms rely on dated lithographic manufacturing processes or molding processes that are not easily scalable and hinder innovative designs of MAP geometries that can be achieved. The DeSimone Laboratory has recently developed a high-resolution continuous liquid interface production (CLIP) 3D printing technology. This 3D printer uses light and oxygen to enable a continuous, noncontact polymerization dead zone at the build surface, allowing for rapid production of MAPs with precise and tunable geometries. Using this tool, we are now able to produce new classes of lattice MAPs (L-MAPs) and dynamic MAPs (D-MAPs) that can deliver both solid state and liquid cargos and are also capable of sampling interstitial fluid. Herein, we will explore how additive manufacturing can revolutionize MAP development and open new doors for minimally invasive drug delivery and diagnostic platforms.

    View details for DOI 10.1021/jacsau.2c00432

    View details for PubMedID 36465529

    View details for PubMedCentralID PMC9709783

  • Medial and Lateral Posterior Tibial Slope in the Skeletally Immature: A Cadaveric Study. Orthopaedic journal of sports medicine Anchustegui, N., Grimm, N. L., Milbrandt, T. A., Rustad, A., Shea, C., Troyer, S., Dingel, A. B., Ganley, T. J., Fabricant, P. D., Shea, K. G. 2022; 10 (4): 23259671221088331


    An increased posterior tibial slope (PTS) results in greater force on the anterior cruciate ligament (ACL) and is a risk factor for ACL injuries. Biomechanical studies have suggested that a reduction in the PTS angle may lower the risk of ACL injuries. However, the majority of these investigations have been in the adult population.To assess the mean medial and lateral PTS on pediatric cadaveric specimens without known knee injuries.Cross-sectional study; Level of evidence, 3.A total of 39 pediatric knee specimens with computed tomography scans were analyzed. Specimens analyzed were between the ages of 2 and 12 years. The PTS of each specimen was measured on sagittal computed tomography slices at 2 locations for the medial and lateral angles. The measurements were plotted graphically by age to account for the variability in development within age groups. The anterior medial and lateral tibial plateau widths were measured. The distance between the top of the tibial plateau and the physis was measured. The independent-samples t test and analysis of variance were used to analyze the measurements.The mean PTS angle for the medial and lateral tibial plateaus was 5.53° ± 4.17° and 5.95° ± 3.96°, respectively. The difference between the PTS angles of the medial and lateral tibial plateaus was not statistically significant (P > .05). When plotted graphically by age, no trend between age and PTS was identified.This data set offers values for the PTS in skeletally immature specimens without a history of ACL injury and suggests that age may not be an accurate predictive factor for PTS.

    View details for DOI 10.1177/23259671221088331

    View details for PubMedID 35400135

    View details for PubMedCentralID PMC8984849