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  • SuFEx Activation with Ca(NTf2)(2) : A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides ORGANIC LETTERS Mahapatra, S., Woroch, C. P., Butler, T. W., Carneiro, S. N., Kwan, S. C., Khasnavis, S. R., Gu, J., Dutra, J. K., Vetelino, B. C., Bellenger, J., Ende, C., Ball, N. D. 2020; 22 (11): 4389–94

    Abstract

    A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds.

    View details for DOI 10.1021/acs.orglett.0c01397

    View details for Web of Science ID 000538848600065

    View details for PubMedID 32459499

    View details for PubMedCentralID PMC7294807

  • Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides ORGANIC LETTERS Mukherjee, P., Woroch, C. P., Cleary, L., Rusznak, M., Franzese, R. W., Reese, M. R., Tucker, J. W., Humphrey, J. M., Etuk, S. M., Kwan, S. C., Ende, C., Ball, N. D. 2018; 20 (13): 3943–47

    Abstract

    A method using calcium triflimide [Ca(NTf2)2] as a Lewis acid to activate sulfonyl fluorides toward nucleophilic addition with amines is described. The reaction converts a wide array of sterically and electronically diverse sulfonyl fluorides and amines into the corresponding sulfonamides in good yield.

    View details for DOI 10.1021/acs.orglett.8b01520

    View details for Web of Science ID 000438469500052

    View details for PubMedID 29888600