Professional Education


  • B.Sc., University of Iceland, Biochemistry (2004)
  • Doctor of Philosophy, University Of Dublin, Trinity College (2008)

Stanford Advisors


  • AC Matin, Postdoctoral Faculty Sponsor

Current Research and Scholarly Interests


My main research projects are focused on the investigation of the therapeutic effect of a novel prodrug-enzyme anticancer therapy and the development of a magnetic resonance imaging system that would enable the assessment of tumor metastasis in vivo, starting from a single cell. I have gained valuable experience in molecular cloning, protein manufacture and protein purification. My previous research included the pre-clinical testing of various different fluorescent reporters, anticancer agents and photoresponsive antibacterial therapeutics. I have successfully collaborated with a range of other researcher, leading to five peer-reviewed publications and and I believe that my diverse research background will be of major help to the proposed project.

Journal Articles


  • Light Induced Antimicrobial Properties of a Brominated Boron Difluoride (BF2) Chelated Tetraarylazadipyrromethene Photosensitizer JOURNAL OF MEDICINAL CHEMISTRY Frimannsson, D. O., Grossi, M., Murtagh, J., Paradisi, F., O'Shea, D. F. 2010; 53 (20): 7337-7343

    Abstract

    Herein we describe a new antimicrobial photodynamic therapeutic (PDT) agent based upon the brominated BF(2) chelated tetraarylazadipyrromethene photosensitizer class. Bis-ammonium salt substitution of the photosensitizer promoted a rapid 10 min uptake into Gram-positive and -negative bacterial strains and pathogenic yeasts. A photosensitizer and light dose response analysis for methicillin-sensitive S. aureus showed an impressive antibacterial efficacy with 1, 2, and 5 ?g/mL 6. Specifically, light activation with a dose of 16 J/cm(2) and 5 ?g/mL 6 resulted in a 6.8 and 3.4 log(10) reduction of S. aureus and a clinically defined methicillin-resistant Staphylococcus aureus (MRSA) strain, respectively. Encouragingly, a broad spectrum pathogen response (using 5 ?g/mL 6 and 75 J/cm(2)) was observed with 3.6 and 5.7 log(10) decreases in viable cell numbers achievable for Gram-negative bacterium E. coli and the pathogenic yeast C. albicans, respectively. The photophysical and cell eradicating characteristics of this bis-cationic PDT agent suggest that it has broad potential in antimicrobial therapeutics.

    View details for DOI 10.1021/jm100585j

    View details for Web of Science ID 000283106300007

    View details for PubMedID 20879783

  • Synthesis and crystallographic analysis of short pyridine based oligoamides as DNA targeting supramolecular binders Supramolecular Chemistry Frimannsson DO, Gunnlaugsson T, Lawler M, McCabe T 2010; 22 (9): 483
  • Water-solubilised BF2-chelated tetraarylazadipyrromethenes ORGANIC & BIOMOLECULAR CHEMISTRY Tasior, M., Murtagh, J., Frimannsson, D. O., McDonnell, S. O., O'Shea, D. F. 2010; 8 (3): 522-525

    Abstract

    Strategic incorporation of sulfonic acid, carboxylic acid or ammonium salt motifs generate water soluble BF(2)-chelated tetraarylazadipyrromethenes which exhibit strong near infra-red (NIR) emissions above 720 nm and can be readily imaged in both eukaryotic and prokaryotic cells.

    View details for DOI 10.1039/b919546g

    View details for Web of Science ID 000273745100003

    View details for PubMedID 20090964

  • Azide Conjugatable and pH Responsive Near-Infrared Fluorescent Imaging Probes ORGANIC LETTERS Murtagh, J., Frimannsson, D. O., O'Shea, D. F. 2009; 11 (23): 5386-5389

    Abstract

    The synthesis and photophysical characteristics of a pH responsive near-infrared fluorescence imaging probe is described. A key feature is the ability to conjugate the probe by an alkyne-azide cycloaddition reaction and its reversible response of fluorescence intensity across the physiological pH range.

    View details for DOI 10.1021/ol902140v

    View details for Web of Science ID 000272038200007

    View details for PubMedID 19883098

  • 4-Amino-1,8-naphthalimide-Based Troger's Bases As High Affinity DNA Targeting Fluorescent Supramolecular Scaffolds ORGANIC LETTERS Veale, E. B., Frimannsson, D. O., Lawler, M., Gunnlaugsson, T. 2009; 11 (18): 4040-4043

    Abstract

    The synthesis and photophysical and biological investigation of fluorescent 1,8-naphthalimide conjugated Troger's bases 1-3 are described. These structures bind strongly to DNA in competitive media at pH 7.4, with concomitant modulation in their fluorescence emission. These structures also undergo rapid cellular uptake, being localized within the nucleus within a few hours, and are cytotoxic against HL60 and (chronic myeloid leukemia) K562 cell lines.

    View details for DOI 10.1021/ol9013602

    View details for Web of Science ID 000269670700004

    View details for PubMedID 19681640

  • New On-Bead Near-Infrared Fluorophores and Fluorescent Sensor Constructs ORGANIC LETTERS Palma, A., Tasior, M., Frimannsson, D. O., Vu, T. T., Meallet-Renault, R., O'Shea, D. F. 2009; 11 (16): 3638-3641

    Abstract

    The facile synthesis and photophysical characterization of new on-bead fluorophores and fluorescent sensors are described. The unique covalent immobilization strategy results in highly fluorescent beads with sharp emission profiles between 650 and 800 nm. Illustrative examples include imaging in an aqueous cellular environment and adaptation to include off/on sensing functionality, proven by a prototypical detection of gaseous HCl.

    View details for DOI 10.1021/ol901413u

    View details for Web of Science ID 000268796700030

    View details for PubMedID 19624121