Honors & Awards
Outstanding Graduate Student Award for Research in Life Sciences, Physical Sciences, and Engineering, Northeastern University (April 2020)
Most First-author Peer-reviewed Journal Publications Award in 2019, College of Engineering, Northeastern University (April 2020)
Most Cited Publications Award in 2019, College of Engineering, Northeastern University (April 2020)
DCF Fellowship Award, College of Engineering, Northeastern University (April 2020)
Best poster award (1st place), PhD poster competition as part of National Engineers Week, College of Engineering, Northeastern University (February 2020)
Travel Award for 2019 AIChE Annual Meeting, "Nanoengineering of an Electroconductive Cardiac Patch", American Institute of Chemical Engineers (AIChE), Orlando, FL (2019)
Outstanding Reviewer Certificate, Elsevier Publisher (August 2018)
Boards, Advisory Committees, Professional Organizations
Associate Editor-in-Chief, International Journal of Nanomedicine (IJN), Dove Medical Press (2020 - Present)
Member & subcommittee of Nanoneuroscience/nanomedicine, Society for Brain Mapping and Therapeutics (SBMT) (2020 - Present)
Editorial Board, Acta Scientific Biotechnology (2020 - Present)
PhD, Northeastern University, Chemical Engineering (in Aspects of Biomedical Engineering and Biotechnology) (2020)
MSc, University of Tehran, Materials Science and Engineering (2013)
BSc, University of Tehran, Materials Science and Engineering (2011)
Joseph Wu, Postdoctoral Faculty Sponsor
- Chitosan/PVA hydrogels incorporated with green synthesized cerium oxide nanoparticles for wound healing applications EUROPEAN POLYMER JOURNAL 2020; 134
- Green nanotechnology-based zinc oxide (ZnO) nanomaterials for biomedical applications: a review JOURNAL OF PHYSICS-MATERIALS 2020; 3 (3)
Biomimetic proteoglycan nanoparticles for growth factor immobilization and delivery
2020; 8 (4): 1127–36
The delivery of growth factors is often challenging due to their short half-life, low stability, and rapid deactivation. In native tissues, the sulfated residual of glycosaminoglycan (GAG) polymer chains of proteoglycans immobilizes growth factors through the proteoglycans'/proteins' complexation with nanoscale organization. These biological assemblies can influence growth factor-cell surface receptor interactions, cell differentiation, cell-cell signaling, and mechanical properties of the tissues. Here, we introduce a facile procedure to prepare novel biomimetic proteoglycan nanocarriers, based on naturally derived polymers, for the immobilization and controlled release of growth factors. We developed polyelectrolyte complex nanoparticles (PCNs) as growth factor nanocarriers, which mimic the dimensions, chemical composition, and growth factor immobilization of proteoglycans in native tissues. PCNs were prepared by a polymer-polymer pair reaction method and characterized for physicochemical properties. Fourier transform infrared spectroscopy (FTIR) analysis indicated that complexation occurred through electrostatic interactions. Transmission electron microscopy (TEM) results showed that the nanocarriers had a diameter of 60 ± 11 nm and 91 ± 33 nm for dermatan sulfate sodium salt-poly-l-lysine (DS-PLL) and gum tragacanth-poly-l-lysine (GT-PLL) complexes, respectively. The colloidal nanoparticles were stable due to their negative zeta potential, i.e.-25 ± 4 mV for DS-PLL and -18 ± 3.5 mV for GT-PLL. Cytocompatibility of PCNs in contact with human bone marrow stromal cells (HS-5) was confirmed through a live/dead assay and metabolic activity measurement. In addition, vascular endothelial growth factor (VEGF) was used to evaluate the ability of PCNs to stabilize growth factors. The capability of PCNs to preserve VEGF activity for up to 21 days was confirmed by analyzing the metabolic and mitogenic characteristics of human umbilical vein endothelial cells (HUVECs). Our results demonstrated the potential applications of these nanoparticles in therapeutic delivery for tissue regeneration applications.
View details for DOI 10.1039/c9bm00668k
View details for Web of Science ID 000517148800008
View details for PubMedID 31389409
GDNF gene-engineered adipose-derived stem cells seeded Emu oil-loaded electrospun nanofibers for axonal regeneration following spinal cord injury
Journal of Drug Delivery Science and Technology
2020; 60: 102095
View details for DOI 10.1016/j.jddst.2020.102095
Wound dressings functionalized with silver nanoparticles: promises and pitfalls.
2020; 12 (4): 2268–91
Infections are the main reason why most people die from burns and diabetic wounds. The clinical challenge for treating wound infections through traditional antibiotics has been growing steadily and has now reached a critical status requiring a paradigm shift for improved chronic wound care. The US Centers for Disease Control have predicted more deaths from antimicrobial-resistant bacteria than from all types of cancers combined by 2050. Thus, the development of new wound dressing materials that do not rely on antibiotics is of paramount importance. Currently, incorporating nanoparticles into scaffolds represents a new concept of 'nanoparticle dressing' which has gained considerable attention for wound healing. Silver nanoparticles (Ag-NPs) have been categorized as metal-based nanoparticles and are intriguing materials for wound healing because of their excellent antimicrobial properties. Ag-NPs embedded in wound dressing polymers promote wound healing and control microorganism growth. However, there have been several recent disadvantages of using Ag-NPs to fight infections, such as bacterial resistance. This review highlights the therapeutic approaches of using wound dressings functionalized with Ag-NPs and their potential role in revolutionizing wound healing. Moreover, the physiology of the skin and wounds is discussed to place the use of Ag-NPs in wound care into perspective.
View details for DOI 10.1039/c9nr08234d
View details for PubMedID 31942896
- Corrigendum to "An update on advances in new developing DNA conjugation diagnostics and ultra-resolution imaging technologies: Possible applications in medical and biotechnological utilities" [Biosens. Bioelectron Volume 144, (1 November 2019), 111633]. Biosensors & bioelectronics 2020; 151: 111904
Green nanotechnology-based drug delivery systems for osteogenic disorders.
Expert opinion on drug delivery
2020; 17 (3): 341–56
Introduction: Current treatments for osteogenic disorders are often successful, however they are not free of drawbacks, such as toxicity or side effects. Nanotechnology offers a platform for drug delivery in the treatment of bone disorders, which can overcome such limitations. Nevertheless, traditional synthesis of nanomaterials presents environmental and health concerns due to its production of toxic by-products, the need for extreme and harsh raw materials, and their lack of biocompatibility over time.Areas covered: This review article contains an overview of the current status of treating osteogenic disorders employing green nanotechnological approaches, showing some of the latest advances in the application of green nanomaterials, as drug delivery carriers, for the effective treatment of osteogenic disorders.Expert opinion: Green nanotechnology, as a potential solution, is understood as the use of living organisms, biomolecules and environmentally friendly processes for the production of nanomaterials. Nanomaterials derived from bacterial cultures or biomolecules isolated from living organisms, such as carbohydrates, proteins, and nucleic acids, have been proven to be effective composites. These nanomaterials introduce enhancements in the treatment and prevention of osteogenic disorders, compared to physiochemically-synthesized nanostructures, specifically in terms of their improved cell attachment and proliferation, as well as their ability to prevent bacterial adhesion.
View details for DOI 10.1080/17425247.2020.1727441
View details for PubMedID 32064959
Enhancement of Loading Efficiency by Coloading of Doxorubicin and Quercetin in Thermoresponsive Polymeric Micelles.
2020; 21 (4): 1427–36
Chemotherapy faces challenges, including poor aqueous solubility of the drugs, and cardiotoxicity. Micellar drug delivery systems (DDS) are used to encapsulate anticancer drugs for better therapeutic effects, however, with poor loading content. Herein, we synthesized a micellar DDS using γ-benzyloxy substituted poly(ε-caprolactone) as the hydrophobic block and coloaded anticancer doxorubicin (Dox) and antioxidant quercetin (Que). γ-Substituted oligo(ethylene) glycol (OEG) poly(ε-caprolactone)s were used as hydrophilic blocks to make the polymers thermoresponsive. Variation of the OEG chain allowed the tunability of the lower critical solution temperature. Moreover, drug loading and release were studied. Thermodynamic stability, size, and morphology were determined by fluorescence measurements, dynamic light scattering, and transmission electron microscopy. Combination loading demonstrated improved loading of Dox and Que. Biological studies were performed using HepG2 human liver cancer and H9c2 rat heart cells. The use of biodegradable, biocompatible, and thermoresponsive polymers along with the coloading approach is a good strategy in developing DDSs.
View details for DOI 10.1021/acs.biomac.9b01742
View details for PubMedID 32149500
The feasibility and usability of DNA-dot bioconjugation to antibody for targeted in vitro cancer cell fluorescence imaging.
Journal of photochemistry and photobiology. B, Biology
2020; 209: 111944
DNA-protein bioconjugation is an appealing target-tracking strategy. The new capability of DNA molecule as a biological nanomaterial endows unique fluorescence and physicochemical properties to be applied in bioimaging. Progression in targeted imaging is contingent on the conjugation of diagnostic nanoparticles to biomolecular signatures, particularly antibody-based ligands. Here, we have reported our recent experience, DNA-dot synthesis and characterization, the covalent conjugation of DNA-dot to goat F(ab')2 IgG and Epidermal Growth Factor Receptor (EGFR) antibodies, DNA-dot@antibody coupling confirmation, and fluorescent targeted imaging of lung cancer cell line. As a result, the average size of DNA-dot was 4.5-5 nm which was conjugated to amine-rich antibodies with returned PO4-1 groups on the DNA-dot surface via PN bond. The synthetic DNA-dots were conjugated to the goat F(ab')2 IgG and tested for fluorescent detection usability by indirect Dot-blot assay. Also, DNA-dot@EGFR conjugates identified lung cancer cells with 84-92% specificity and 100% sensitivity in five concentrations, associated with 0.0025 to 0.04 g 100 μL-1 DNA-dot. The results demonstrated that bioconjugated DNA-dot can do the diagnosis profiling of molecular biomarkers. Generally, DNA-dot bioconjugation with antibody is implemented within two days and biomarker detection takes one day. Consequently, DNA-dot@antibody is potentially a toxic-free, swift, and efficient method of antibody labeling that opens up new horizons in fluorescent nanoimaging in the field of cancer cell detection.
View details for DOI 10.1016/j.jphotobiol.2020.111944
View details for PubMedID 32619869
Green nanotechnology-based Gold Nanomaterials for Hepatic Cancer Therapeutics: A Systematic Review
Iranian Journal of Pharmaceutical Research
View details for DOI 10.22037/ijpr.2020.113820.14504
Bioactive and elastic nanocomposites with antimicrobial properties for bone tissue regeneration
ACS Applied Bio Materials
2020; 3: 3313-3325
View details for DOI 10.1021/acsabm.0c00250
Electroconductive Nanobiomaterials for Tissue Engineering and Regenerative Medicine
2020; 2 (2): 120-149
View details for DOI 10.1089/bioe.2020.0021
Emerging Antineoplastic Biogenic Gold Nanomaterials for Breast Cancer Therapeutics: A Systematic Review
INTERNATIONAL JOURNAL OF NANOMEDICINE
2020; 15: 3577–95
Breast cancer remains as a concerning global health issue, being the second leading cause of cancer deaths among women in the United States (US) in 2019. Therefore, there is an urgent and substantial need to explore novel strategies to combat breast cancer. A potential solution may come from the use of cancer nanotechnology, an innovative field of study which investigates the potential of nanomaterials for cancer diagnosis, therapy, and theranostic applications. Consequently, the theranostic functionality of cancer nanotechnology has been gaining much attention between scientists during the past few years and is growing exponentially. The use of biosynthesized gold nanoparticles (AuNPs) has been explored as an efficient mechanism for the treatment of breast cancer. The present study supposed a global systematic review to evaluate the effectiveness of biogenic AuNPs for the treatment of breast cancer and their anticancer molecular mechanisms through in vitro studies. Online electronic databases, including Cochrane, PubMed, Scopus, Web of Science, Science Direct, ProQuest, and Embase, were searched for the articles published up to July 16, 2019. Our findings revealed that plant-mediated synthesis was the most common approach for the generation of AuNPs. Most of the studies reported spherical or nearly spherical-shaped AuNPs with a mean diameter less than 100 nm in size. A significantly larger cytotoxicity was observed when the biogenic AuNPs were tested towards breast cancer cells compared to healthy cells. Moreover, biogenic AuNPs demonstrated significant synergistic activity in combination with other anticancer drugs through in vitro studies. Although we provided strong and comprehensive preliminary in vitro data, further in vivo investigations are required to show the reliability and efficacy of these NPs in animal models.
View details for DOI 10.2147/IJN.S240293
View details for Web of Science ID 000533482100001
View details for PubMedID 32547015
View details for PubMedCentralID PMC7245458
Bioprinters for organs-on-chips
2019; 11 (4): 042002
Recent advances in bioprinting technologies have enabled rapid manufacturing of organ-on-chip models along with biomimetic tissue microarchitectures. Bioprinting techniques can be used to integrate microfluidic channels and flow connections in organ-on-chip models. We review bioprinters in two categories of nozzle-based and optical-based methods, and then discuss their fabrication parameters such as resolution, replication fidelity, fabrication time, and cost for micro-tissue models and microfluidic applications. The use of bioprinters has shown successful replicates of functional engineered tissue models integrated within a desired microfluidic system, which facilitates the observation of metabolism or secretion of models and sophisticated control of a dynamic environment. This may provide a wider order of tissue engineering fabrication in mimicking physiological conditions for enhancing further applications such as drug development and pathological studies.
View details for DOI 10.1088/1758-5090/ab2798
View details for Web of Science ID 000487215700001
View details for PubMedID 31170695
View details for PubMedCentralID PMC6756175
Would Colloidal Gold Nanocarriers Present An Effective Diagnosis Or Treatment For Ischemic Stroke?
INTERNATIONAL JOURNAL OF NANOMEDICINE
2019; 14: 8013–31
This study was conducted to evaluate OX26-PEG-coated gold nanoparticles (GNPs) (OX26@GNPs) as a novel targeted nanoparticulate system on cell survival after ischemic stroke.Dynamic light scattering (DLS), zeta sizer, and transmission electron microscopy (TEM) were performed to characterize the OX26@GNPs. The effect of OX26@GNPs on infarct volume, neuronal loss, and necroptosis was evaluated 24 h after reperfusion using 2, 3,5-Triphenyltetrazolium chloride (TTC) staining, Nissl staining and Western blot assay, respectively.Conjugation of OX26-PEG to the surface of the 25 nm colloidal gold particles increased their size to 32±2 nm, while a zeta potential change of -40.4 to 3.40 mV remarkably increased the stability of the nanoparticles. Most importantly, OX26@GNPs significantly increased the infarcted brain tissue, while bare GNPs and PEGylated GNPs had no effect on the infarct volume. However, our results indicated an extension of necroptotic cell death, followed by cell membrane damage.Collectively, our results showed that the presently formulated OX26@GNPs are not suitable nanocarriers nor contrast agents under oxidative stress for the diagnosis and treatment of ischemic stroke. Moreover, our findings suggest that the cytotoxicity of GNPs in the brain is significantly associated with their surface charge.
View details for DOI 10.2147/IJN.S210035
View details for Web of Science ID 000489021700001
View details for PubMedID 31632015
View details for PubMedCentralID PMC6789974
- Synthesis, characterization and in vitro evaluation of magnetic nanoparticles modified with PCL-PEG-PCL for controlled delivery of 5FU (vol 46, pg S938, 2017) ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 2019; 47 (1): 2917
- Nanotechnology and picotechnology: A new arena for translational medicine BIOMATERIALS IN TRANSLATIONAL MEDICINE 2019: 191–212
The use of stromal vascular fraction (SVF), platelet-rich plasma (PRP) and stem cells in the treatment of osteoarthritis: an overview of clinical trials
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
2019; 47 (1): 882–90
Osteoarthritis (OA) is a major cause of disability across the world, which its prevalence is relatively high in elder population. Current accepted therapies such as exercise, anti-inflammatory drugs and intra-articular inoculation of corticosteroids are aimed at controlling symptoms in the affected patients. Surgical options including arthroplasty, osteotomy and joint replacement are other choices of treatment, which are invasive and can be applied in case of failure of conventional therapies. In the last few decades, efforts to treat musculoskeletal diseases are being increasingly focused on regenerative cellular therapies. Stromal vascular fraction (SVF), which obtained from adipose tissue, contains a variety of cells include mesenchymal stem cells (MSCs) and has shown to be effective in cartilage repair. Autologous blood products such as platelet-rich plasma (PRP) act as an adjuvant of surgical treatment and its intra-articular delivery has shown beneficial effects for OA treatment. Given the efficacy of such treatment approaches in OA, this paper discusses both preclinical and clinical evidence with major focus on clinical trials.
View details for DOI 10.1080/21691401.2019.1576710
View details for Web of Science ID 000461718500001
View details for PubMedID 30887856
The effect of chrysin-curcumin-loaded nanofibres on the wound-healing process in male rats
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
2019; 47 (1): 1642–52
The aim of the present study was to produce chrysin-curcumin-loaded PCL-PEG nanofibres by an electrospinning technique and to evaluate the biological activity of the chrysin-curcumin-loaded PCL-PEG fibres for wound healing and its related genes using in vivo methods.The electrospinning method was carried out for the preparation of the chrysin, curcumin and chrysin-curcumin-loaded PCL-PEG nanofibres with different concentrations. FTIR and SEM were performed to characterize the chemical structures and morphology of the nanofibres. In vitro drug release, as well as in vivo wound-healing studies were investigated in male rats. The expressions of genes related to the wound-healing process were also evaluated by real-time PCR.Our study showed that the chrysin-curcumin-loaded nanofibres have anti-inflammatory properties in several stages of the wound-healing process by affecting the IL-6, MMP-2, TIMP-1, TIMP-2 and iNOS gene expression. Our results demonstrated that the effect of the chrysin-loaded nanofibre, the curcumin-loaded nanofibre and the chrysin-curcumin-loaded nanofibre in the wound-healing process is dose dependent and in accordance with the obtained results in that it might affect the inflammation phase more than the other stages of the wound-healing process.We have introduced chrysin-curcumin-loaded PCL-PEG nanofibres as a novel compound for shortening the duration of the wound-healing process.
View details for DOI 10.1080/21691401.2019.1594855
View details for Web of Science ID 000465907400002
View details for PubMedID 31027431
Development Development and characterization of a novel conductive polyaniline-g-polystyrene/Fe(3)O(4 )nanocomposite for the treatment of cancer
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
2019; 47 (1): 873–81
The goal of this study is to synthesize, characterize and investigate some physicochemical properties of conductive polyaniline-g-polystyrene/Fe3O4 (Fe3O4/PSt-g-PANi) nanocomposites. For this purpose, initially, Fe3O4 nanoparticles were synthesized by a co-precipitation method. Then, the desired nanocomposite was synthesized in two steps. First, the atom transfer radical polymerization (ATRP) of styrene was performed using an ATRP initiator attached to the surface of Fe3O4 nanoparticles, followed by functionalization of the Fe3O4-PSt with amine groups (-NH2). Second, surface oxidative graft copolymerization of aniline was accomplished using the -NH2 moieties on the Fe3O4/PSt-NH2 as the anchoring sites. The prepared materials were characterized by various instruments, including TEM, SEM, TGA, EDX, FT-IR, XRD and conductivity measurements. The results indicated that the synthesized conductive polymer/Fe3O4 nanocomposites had higher electrical conductivity and thermal resistance than those of the corresponding homopolymers.
View details for DOI 10.1080/21691401.2019.1575839
View details for Web of Science ID 000461286000003
View details for PubMedID 30873875
- Three-Dimensional Graphene Foams: Synthesis, Properties, Biocompatibility, Biodegradability, and Applications in Tissue Engineering ACS BIOMATERIALS SCIENCE & ENGINEERING 2019; 5 (1): 193–214
Fabrication of Three-Dimensional Scaffolds Based on Nano-biomimetic Collagen Hybrid Constructs for Skin Tissue Engineering
2018; 3 (8): 8605–11
Three-dimensional (3D) biodegradable and biomimetic porous scaffolds are ideal frameworks for skin tissue engineering. In this study, hybrid constructs of 3D scaffolds were successfully fabricated by the freeze-drying method from combinations of the type I collagen (Col) and synthetic poly(lactic acid) (PLLA) or polycaprolactone (PCL). Four different groups of 3D porous scaffolds including PCL, PCL-Col, PCL-PLLA, and PCL-PLLA-Col were fabricated and systematically characterized by hydrogen nuclear magnetic resonance, Fourier transform infrared spectroscopy, and scanning electron microscopy (SEM). Adipose tissue-derived mesenchymal stem cells (AT-MSCs) were seeded in all scaffolds, and the viability, proliferation, and adhesion of the cells were investigated using dimethylthiazol diphenyltetrazolium bromide assay and SEM. The results showed that scaffolds containing Col, particularly PCL-PLLA-Col scaffold, with pore sizes close to 400 nm and being sufficiently interconnected, have significantly greater potential (p < 0.01) for encouraging AT-MSCs adhesion and growth. The PCL-PLLA provided a mechanically stronger mesh support, and the type I Col microsponges encouraged excellent cell adhesion and tissue formation. The scaffold with the best properties could be an appropriate functional candidate for the preparation of artificial skin constructs.
View details for DOI 10.1021/acsomega.8b01219
View details for Web of Science ID 000440617900018
View details for PubMedID 31458990
View details for PubMedCentralID PMC6644454
- Role of dendrimers in advanced drug delivery and biomedical applications: A Review Experimental Oncology 2018; 40 (3): 1-6
Current developments in green synthesis of metallic nanoparticles using plant extracts: a review
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
2018; 46: S336–S343
Metal nanoparticles (MNPs) produced by green approaches have received global attention because of their physicochemical characteristics and their applications in the field of biotechnology. In recent years, the development of synthesizing NPs by plant extracts has become a major focus of researchers because of these NPs have low hazardous effect in the environment and low toxicity for the human body. Synthesized NPs from plants are not only more stable in terms of size and shape, also the yield of this method is higher than the other methods. Moreover, some of these MNPs have shown antimicrobial activity which is consistently confirmed in past few years. Plant extracts have been used as reducing agent and stabilizer of NPs in which we can reduce the toxicity in the environment as well as the human body only by not using chemical agents. Furthermore, the presence of some specific materials in plant extracts could be extremely helpful and effective for the human body; for instance, polyphenol, which may have antioxidant effects has the capability for capturing free radicals before they can react with other biomolecules and cause serious damages. In this article, we focused on of the most common plants which are regularly used to synthesize MNPs along with various methods for synthesizing MNPs from plant extracts.
View details for DOI 10.1080/21691401.2018.1492931
View details for Web of Science ID 000460141900033
View details for PubMedID 30043657
Synthesis, characterization and in vitro evaluation of magnetic nanoparticles modified with PCL-PEG-PCL for controlled delivery of 5FU
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
2018; 46: S938–S945
Magnetic nanoparticles have properties that cause to apply them in cancer therapy and vehicles for the delivery of drugs such as 5FU, especially when they are modified with biocompatible copolymers. The aim of this study is to modify superparamagnetic iron oxide nanoparticles (SPIONPs) with PCL-PEG-PCL copolymers and then utilization of these nanoparticles for encapsulation of anticancer drug 5FU. The ring-opening polymerization (ROP) was used for the synthesis of PCL-PEG-PCL copolymer by ε-caprolactone (PCL) and polyethylene glycol (PEG2000). We used the double emulsion method (water/oil/water) to prepare 5FU-encapsulated Fe3O4 magnetic nanoparticles modified with PCL-PEG-PCL copolymer. Chemical structure and magnetic properties of 5FU-loaded magnetic-polymer nanoparticles were investigated systematically by employing FT-IR, XRD, VSM and SEM techniques. In vitro release profile of 5FU-loaded NPs was also determined. The results showed that the encapsulation efficiency value for nanoparticles were 90%. Moreover, the release of 5FU is significantly higher at pH 5.8 compared to pH 7.4. Therefore, these nanoparticles have sustained release and can apply for cancer therapy.
View details for DOI 10.1080/21691401.2018.1439839
View details for Web of Science ID 000457049400087
View details for PubMedID 29468888
Nanostructured Fibrous Membranes with Rose Spike-Like Architecture
2017; 17 (10): 6235–40
Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities to pristine polymers. The majority of the studies have focused on the incorporation of spherical nanoparticles within the composite fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) nanoparticles into fibrous scaffolds fabricated by electrospinning. The addition of the branched particles resulted in their protrusion from fibers, mimicking the architecture of a rose stem. We demonstrated that the encapsulation of different-shape particles significantly influences the physicochemical and biological activities of the resultant composite scaffolds. In particular, the branched nanoparticles induced heterogeneous crystallization of the polymeric matrix and enhance the ultimate mechanical strain and strength. Moreover, the three-dimensional (3D) nature of the branched ZnO nanoparticles enhanced adhesion properties of the composite scaffolds to the tissues. In addition, the rose stem-like constructs offered excellent antibacterial activity, while supporting the growth of eukaryote cells.
View details for DOI 10.1021/acs.nanolett.7b02929
View details for Web of Science ID 000413057500052
View details for PubMedID 28819978
View details for PubMedCentralID PMC5683165
- Nanostructured MnCo2O4 synthesized via co-precipitation method for SOFC interconnect application INTERNATIONAL JOURNAL OF HYDROGEN ENERGY 2016; 41 (45): 20640–49
- Fabrication and characterization of nanostructured Ba-doped BiFeO3 porous ceramics MATERIALS SCIENCE-POLAND 2016; 34 (1): 148–56
- High performance Ni-CNTs catalyst: synthesis and characterization RSC ADVANCES 2016; 6 (52): 47072–82
- Intermediate milling energy optimization to enhance the characteristics of barium hexaferrite magnetic nanoparticles JOURNAL OF ALLOYS AND COMPOUNDS 2015; 640: 162–68
- Destructive Interactions between Pore Forming Agents and Matrix Phase during the Fabrication Process of Porous BiFeO3 Ceramics JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 2015; 31 (8): 798–805
- Synthesis of nano-structured Bi1-xBaxFeO3 ceramics with enhanced magnetic and electrical properties MATERIALS CHEMISTRY AND PHYSICS 2015; 162: 106–12
- The effects of mechanical activation energy on the solid-state synthesis process of BiFeO3 JOURNAL OF ALLOYS AND COMPOUNDS 2015; 622: 548–56
Synthesis of nano-structured La0.6Sr0.4Co0.2Fe0.8O3 perovskite by co-precipitation method
Journal of Ultrafine Grained and Nanostructured Materials
2015; 48: 45-52
View details for DOI 10.7508/JUFGNSM.2015.01.007
- Characterization of nano-structured multiferroic bismuth ferrite produced via solid state reaction route TRANS TECH PUBLICATIONS LTD. 2014: 683–87
- Synthesis of nano-structured bismuth ferrite by mechano-thermal route TRANS TECH PUBLICATIONS LTD. 2014: 722–26
La0.6Sr0.4Co0.2Fe0.8O3 perovskite cathode for Intermediate temperature Solid Oxide Fuel Cell: A comparative study
Iranian Journal of Hydrogen & Fuel Cells
2014; 4: 239-246
View details for DOI 10.22104/IJHFC.2015.175