Bio

Edward completed his undergraduate education at Loyola Marymount University before beginning his graduate studies at Stanford University.

Professional Affiliations and Activities

  • Member, American Chemical Society (2016 - Present)
  • Member, American Association of Chemistry Teachers (2017 - Present)
  • Member, National Science Teacher Association (2016 - Present)
  • Member, American Society for Biochemistry and Molecular Biology (2018 - Present)

Education & Certifications

  • B.S. Biochemistry, Loyola Marymount University (2017)

Patents

  • Paul Wender, Zach Owen Gentry, David Fanelli, Quang Luu-Nguyen, Owen McAteer, Edward Njoo. "United States Patent 192521 Synthesis of Tigilanol Tiglate and Analogs Thereof", Leland Stanford Junior University, Mar 10, 2022
  • Paul Wender, Zach Owen Gentry, David Fanelli, Quang Luu-Nguyen, Owen McAteer, Edward Njoo. "United States Patent 192521 Synthesis of Tigilanol Tiglate and Analogs Thereof", Leland Stanford Junior University, Mar 10, 2022

Contact

Additional Info

Current Research and Scholarly Interests

Organic Chemistry

All Publications

  • Practical synthesis of the therapeutic leads tigilanol tiglate and its analogues. Nature chemistry Wender, P. A., Gentry, Z. O., Fanelli, D. J., Luu-Nguyen, Q. H., McAteer, O. D., Njoo, E. 2022

    Abstract

    Tigilanol tiglate is a natural product diterpenoid in clinical trials for the treatment of a broad range of cancers. Its unprecedented protein kinase C isoform selectivity make it and its analogues exceptional leads for PKC-related clinical indications, which include human immunodeficiency virus and AIDS eradication, antigen-enhanced cancer immunotherapy, Alzheimer's disease and multiple sclerosis. Currently, the only source of tigilanol tiglate is a rain forest tree, Fontainea picrosperma, whose limited number and restricted distribution (northeastern Australia) has prompted consideration of designed tree plantations to address supply needs. Here we report a practical laboratory synthesis of tigilanol tiglate that proceeds in 12 steps (12% overall yield, >80% average yield per step) and can be used to sustainably supply tigilanol tiglate and its analogues, the latter otherwise inaccessible from the natural source. The success of this synthesis is based on a unique strategy for the installation of an oxidation pattern common to many biologically active tiglianes, daphnanes and their analogues.

    View details for DOI 10.1038/s41557-022-01048-2

    View details for PubMedID 36192432

  • Resourceful and Effective Ways of Bridging Afterschool STEM Programs and Local Community Connected Science Learning Njoo, E., Narain, S., Pabbisetty, L., Agrawal, M. 2018; 1 (8)
  • Determining amyloidogenicity of Islet Amyloid Polypeptide (IAPP) across mammalian species Moffet, D., Njoo, E., Rinauro, D., Pilcher, S., Palato, L., Johnstone, B., Menefee, K., Tun, A. AMER CHEMICAL SOC. 2017

    View details for Web of Science ID 000430568504220

  • Acclimation to elevated emersion temperature has no effect on susceptibility to acute, heat-induced lipid peroxidation in an intertidal mussel (Mytilus californianus) MARINE BIOLOGY Jimenez, A., Alves, S., Dallmer, J., Njoo, E., Roa, S., Dowd, W. 2016; 163 (3)

    View details for DOI 10.1007/s00227-016-2828-8

    View details for Web of Science ID 000372302600011

https://orcid.org/0000-0001-6693-8219