Bio


I am an enthusiastic learner, team player, and effective doer, and I call upon these qualities day by day, both as an engineer and leader in the community.

- My graduate work in the Gambhir Lab demonstrates my long-term commitment to learning both the depth and breadth of a scientific topic (PET tracer development for early cancer detection)
- Two research positions in Switzerland displayed my passion for international collaboration, flexibility
in new work environments, and capability to work among diverse teams.
- Six months on a Senior Design Project showcased my ability to move a project from design to
realization at a fast pace.

I’m interested in connecting with former colleagues and classmates as well as the creative people who will be a part of my future. Please reach out if your research interests fit mine.

Honors & Awards


  • Training in Biomedical Imaging & Instrumentation (TBI2) Fellow, Stanford Bioengineering Department (2016-2017)
  • UC Regents Scholar, The Regents of the University of California (2010-2014)
  • Whitaker Foundation Undergraduate Research Fellow, Whitaker International Program (2014)
  • ThinkSwiss Research Scholarship, Embassy of Switzerland (2014)

Professional Affiliations and Activities


  • Member, Tau Beta Pi (2015 - Present)

Education & Certifications


  • Master of Science, Stanford University, BIOE-MS (2017)
  • Bachelor of Science, UC Davis, Biomedical Engineering (2015)

Service, Volunteer and Community Work


  • Stanford Science Penpals, Stanford University

    Mentor high school students via letter communication. Describe my current work and how I got here, and encourage the students to enter STEM fields.

    Location

    California

Current Research and Scholarly Interests


Biomedical Imaging and Instrumentation, Early Cancer Detection

All Publications


  • Tumor Cell-Derived Extracellular Vesicle-Coated Nanocarriers: An Efficient Theranostic Platform for the Cancer-Specific Delivery of Anti-miR-21 and Imaging Agents. ACS nano Jc Bose, R., Uday Kumar, S., Zeng, Y., Afjei, R., Robinson, E., Lau, K., Bermudez, A., Habte, F., Pitteri, S. J., Sinclair, R., Willmann, J. K., Massoud, T. F., Gambhir, S. S., Paulmurugan, R. 2018

    Abstract

    MicroRNAs are critical regulators of cancer initiation, progression, and dissemination. Extensive evidence suggests that the inhibition of over-expressed oncogenic miRNA function can be a robust strategy for anticancer therapy. However, in vivo targeted delivery of miRNA therapeutics to various types of cancers remains a major challenge. Inspired by their natural synthesis and cargo delivery capabilities, researchers have exploited tumor cell-derived extracellular vesicles (TEVs) for the cancer-targeted delivery of therapeutics and theranostics. Here, we investigate a TEV-based nanoplatform for multimodal miRNA delivery and phototherapy treatments as well as the magnetic resonance imaging of cancer. We demonstrated loading of anti-miR-21 that blocks the function of endogenous oncogenic miR-21 over-expressed in cancer cells into and subsequent delivery by TEVs derived from 4T1 cells. We also produced Cy5-anti-miR-21-loaded TEVs from two other cancer cell lines (HepG2 and SKBR3) and confirmed their robust homologous and heterologous transfection efficiency and intracellular Cy5-anti-miR-21 delivery. Additionally, TEV-mediated anti-miR-21 delivery attenuated doxorubicin (DOX) resistance in breast cancer cells with a 3-fold higher cell kill efficiency than in cells treated with DOX alone. We then investigated TEVs as a biomimetic source for the functionalization of gold-iron oxide nanoparticles (GIONs) and demonstrated nanotheranostic properties of TEV-GIONs in vitro. TEV-GIONs demonstrated excellent T2 contrast in in vitro magnetic resonance (MR) imaging and resulted in efficient photothermal effect in 4T1 cells. We also evaluated the biodistribution and theranostic property of anti-miR-21 loaded TEV-GIONs in vivo by labeling with indocyanine green near-infrared dye. We further validated the tumor specific accumulation of TEV-GIONs using MR imaging. Our findings demonstrate that the distribution pattern of the TEV-anti-miR-21-GIONs correlated well with the tumor-targeting capability as well as the activity and efficacy obtained in response to doxorubicin combination treatments. TEVs and TEV-GIONs are promising nanotheranostics for future applications in cancer molecular imaging and therapy.

    View details for DOI 10.1021/acsnano.8b02587

    View details for PubMedID 30346694