Doctor, University Paris XI, Neuroscience (2016)
Master of Science, Universite De Paris Xi (Paris-Sud) (2012)
Licence, Universite De Caen (2010)
Diplom, Unlisted School (2009)
H Craig Heller, Postdoctoral Faculty Sponsor
Mouse Gambling Task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes.
Sleep loss is associated with sleepiness, sustained attention, and memory deficits. However, vulnerability of higher cognitive processes (i.e. decision making) to sleep debt is less understood. Therefore, a major challenge is to understand why and how higher cognitive processes are affected by sleep debt. We had established in mice correlations between individual decision-making strategies, prefrontal activity, and regional monoaminergic levels. Now, we show that acute sleep debt (ASD) disturbs decision-making processes and provokes brain regional modifications of serotonin and dopamine that could explain why ASD promotes inflexible and more risk-prone behaviors. Finally, we highlight, for the first time, that in a large group of healthy inbred mice some of them are more sensitive to ASD by showing inflexible behavior and decision-making deficits. We were also able to predict mice that would be the most vulnerable to ASD depending of their behavior before ASD exposure.
View details for DOI 10.1093/sleep/zsy168
View details for PubMedID 30304537
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