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All Publications


  • Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models. Cancer letters Soto, F. n., GuimarĂ£es, C. F., Reis, R. L., Franco, W. n., Rizvi, I. n., Demirci, U. n. 2021

    Abstract

    Tissue engineered organoids are simple biomodels that can emulate the structural and functional complexity of specific organs. Here, we review developments in three-dimensional (3D) artificial cell constructs to model gastrointestinal dynamics towards cancer diagnosis. We describe bottom-up approaches to fabricate close-packed cell aggregates, from the use of biochemical and physical cues to guide the self-assembly of organoids, to the use of engineering approaches, including 3D printing/additive manufacturing and external field-driven protocols. Finally, we outline the main challenges and possible risks regarding the potential translation of gastrointestinal organoids from laboratory settings to patient-specific models in clinical applications.

    View details for DOI 10.1016/j.canlet.2021.01.023

    View details for PubMedID 33577978

  • Engineering the Interaction Dynamics between Nano-Topographical Immunocyte-Templated Micromotors across Scales from Ions to Cells. Small (Weinheim an der Bergstrasse, Germany) Wang, J., Ahmed, R., Zeng, Y., Fu, K., Soto, F., Sinclair, B., Soh, H. T., Demirci, U. 2020: e2005185

    Abstract

    Manufacturing mobile artificial micromotors with structural design factors, such as morphology nanoroughness and surface chemistry, can improve the capture efficiency through enhancing contact interactions with their surrounding targets. Understanding the interplay of such parameters targeting high locomotion performance and high capture efficiency at the same time is of paramount importance, yet, has so far been overlooked. Here, an immunocyte-templated nano-topographical micromotor is engineered and their interactions with various targets across multiple scales, from ions to cells are investigated. The macrophage templated nanorough micromotor demonstrates significantly increased surface interactions and significantly improved and highly efficient removal of targets from complex aqueous solutions, including in plasma and diluted blood, when compared to smooth synthetic material templated micromotors with the same size and surface chemistry. These results suggest that the surface nanoroughness of the micromotors for the locomotion performance and interactions with the multiscale targets should be considered simultaneously, for they are highly interconnected in design considerations impacting applications across scales.

    View details for DOI 10.1002/smll.202005185

    View details for PubMedID 33174334

  • Medical Micro/Nanorobots in Precision Medicine Medical Micro/Nanorobots in Precision Medicine Soto, F., Wang, J., Ahmed, R., Demirci, U. 2020: 2002203

    View details for DOI 10.1002/advs.202002203