Professional Education


  • Doctor of Philosophy, Michigan State University (2017)

All Publications


  • Propene as an Atom-Economical Linchpin for Concise Total Synthesis of Polyenes: Piericidin A. Journal of the American Chemical Society Trost, B. M., Gholami, H. 2018

    Abstract

    A concise and convergent total synthesis of piericidin A is disclosed. The synthesis hinges on the utilization of propene as a synthetic linchpin to merge the properly elaborated alkyne fragments, leading to the 1,3,6-triene motif of piericidin A. Utilization of propene as a unique alkene, capable of sequential coupling with two alkynes, is further illustrated in the context of various 1,3,6-triene products. The latter process proceeds with high atom economy and efficiently gives rise to complex frameworks from readily accessible alkyne substrates. This strategic C-C bond formation offers an orthogonal paradigm in the design of synthetic routes, leading to higher step economy and more efficient syntheses of polyunsaturated natural products.

    View details for PubMedID 30173519