Professional Education

  • Bachelor of Arts, Harvard University (2009)
  • Doctor of Philosophy, Stanford University, BIO-PHD (2017)

Lab Affiliations

All Publications

  • Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat. Nature ecology & evolution Zepeda Mendoza, M. L., Xiong, Z., Escalera-Zamudio, M., Runge, A. K., Thézé, J., Streicker, D., Frank, H. K., Loza-Rubio, E., Liu, S., Ryder, O. A., Samaniego Castruita, J. A., Katzourakis, A., Pacheco, G., Taboada, B., Löber, U., Pybus, O. G., Li, Y., Rojas-Anaya, E., Bohmann, K., Carmona Baez, A., Arias, C. F., Liu, S., Greenwood, A. D., Bertelsen, M. F., White, N. E., Bunce, M., Zhang, G., Sicheritz-Pontén, T., Gilbert, M. P. 2018; 2 (4): 659–68


    Adaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adaptation. Specifically, we assembled its high-quality reference genome (scaffold N50 = 26.9 Mb, contig N50 = 36.6 kb) and gut metagenome, and compared them against those of insectivorous, frugivorous and carnivorous bats. Our analyses showed a particular common vampire bat genomic landscape regarding integrated viral elements, a dietary and phylogenetic influence on gut microbiome taxonomic and functional profiles, and that both genetic elements harbour key traits related to the nutritional (for example, vitamin and lipid shortage) and non-nutritional (for example, nitrogen waste and osmotic homeostasis) challenges of sanguivory. These findings highlight the value of a holistic study of both the host and its microbiota when attempting to decipher adaptations underlying radical dietary lifestyles.

    View details for DOI 10.1038/s41559-018-0476-8

    View details for PubMedID 29459707

    View details for PubMedCentralID PMC5868727

  • Frequency shifting reduces but does not eliminate acoustic interference between echolocating bats: A theoretical analysis The Journal of the Acoustical Society of America Perkins, M. L., Frank, H. K., Pauly, J. M., Hadly, E. A. 2017; 142: 2133

    View details for DOI 10.1121/1.5006928

  • Phylogeny, Traits, and Biodiversity of a Neotropical Bat Assemblage: Close Relatives Show Similar Responses to Local Deforestation. The American naturalist Frank, H. K., Frishkoff, L. O., Mendenhall, C. D., Daily, G. C., Hadly, E. A. 2017; 190 (2): 200–212


    If species' evolutionary pasts predetermine their responses to evolutionarily novel stressors, then phylogeny could predict species survival in an increasingly human-dominated world. To understand the role of phylogenetic relatedness in structuring responses to rapid environmental change, we focused on assemblages of Neotropical bats, an ecologically diverse and functionally important group. We examined how taxonomic and phylogenetic diversity shift between tropical forest and farmland. We then explored the importance of evolutionary history by ascertaining whether close relatives share similar responses to environmental change and which species traits might mediate these trends. We analyzed a 5-year data set (5,011 captures) from 18 sites in a countryside landscape in southern Costa Rica using statistical models that account and correct for imperfect detection of species across sites, spatial autocorrelation, and consideration of spatial scale. Taxonomic and phylogenetic diversity decreased with deforestation, and assemblages became more phylogenetically clustered. Species' responses to deforestation were strongly phylogenetically correlated. Body mass and absolute wing loading explained a substantial portion of species variation in species' habitat preferences, likely related to these traits' influence on maneuverability in cluttered forest environments. Our findings highlight the role that evolutionary history plays in determining which species will survive human impacts and the need to consider diversity metrics, evolutionary history, and traits together when making predictions about species persistence for conservation or ecosystem functioning.

    View details for DOI 10.1086/692534

    View details for PubMedID 28731793

  • Opportunity for some, extinction for others: the fate of tetrapods in the Anthropocene EVOLUTIONARY ECOLOGY RESEARCH Solari, K. A., Frank, H. K., Frishkoff, L. O., Hsu, J. L., Kemp, M. E., Mychajliw, A. M., Hadly, E. A. 2016; 17 (6): 787-813
  • Anthropogenic impacts on Costa Rican bat parasitism are sex specific ECOLOGY AND EVOLUTION Frank, H. K., Mendenhall, C. D., Judson, S. D., Daily, G. C., Hadly, E. A. 2016; 6 (14): 4898-4909

    View details for DOI 10.1002/ece3.2245

    View details for Web of Science ID 000380033400022

  • Multiple paths to aquatic specialisation in four species of Central American Anolis lizards JOURNAL OF NATURAL HISTORY Munoz, M. M., Crandell, K. E., Campbell-Staton, S. C., Fenstermacher, K., Frank, H. K., Van Middlesworth, P., Sasa, M., Losos, J. B., Herrel, A. 2015; 49 (27-28): 1717-1730
  • Bartonellae are Prevalent and Diverse in Costa Rican Bats and Bat Flies Zoonoses and Public Health Judson, S. D., Frank, H. K., Hadly, E. A. 2015; 62 (8): 609-617

    View details for DOI 10.1111/zph.12188