Bachelor of Arts, University of Colorado Boulder (2008)
Doctor of Philosophy, University of California Santa Barbara (2013)
Sebastian Doniach, Postdoctoral Faculty Sponsor
Observation of correlated X-ray scattering at atomic resolution.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2014; 369 (1647)
Tools to study disordered systems with local structural order, such as proteins in solution, remain limited. Such understanding is essential for e.g. rational drug design. Correlated X-ray scattering (CXS) has recently attracted new interest as a way to leverage next-generation light sources to study such disordered matter. The CXS experiment measures angular correlations of the intensity caused by the scattering of X-rays from an ensemble of identical particles, with disordered orientation and position. Averaging over 15 496 snapshot images obtained by exposing a sample of silver nanoparticles in solution to a micro-focused synchrotron radiation beam, we report on experimental efforts to obtain CXS signal from an ensemble in three dimensions. A correlation function was measured at wide angles corresponding to atomic resolution that matches theoretical predictions. These preliminary results suggest that other CXS experiments on disordered ensembles-such as proteins in solution-may be feasible in the future.
View details for DOI 10.1098/rstb.2013.0315
View details for PubMedID 24914148
- Observation of correlated X-ray scattering at atomic resolution PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 2014; 369 (1647)