All Publications


  • Carbon-Nitrogen Bond Formation via the Vanadium Oxo Catalyzed Sigmatropic Functionalization of Allenols. Organic letters Trost, B. M., Tracy, J. S. 2017; 19 (10): 2630-2633

    Abstract

    A vanadium catalyzed 1,3-rearrangement of allenols to form transient vanadium enolates that selectively couple with electrophilic nitrogen sources is reported even in the presence of competing simple protonation and Alder-ene pathways. Hydrazine products can be cyclized in a 6-endo-trig fashion which, upon reductive cleavage of the N-N bond, yield 1,4-diamines. Additionally, cleavage of the N-N bond before cyclization can be achieved to form β-hydroxy amines, a common structural motif of biologically active compounds.

    View details for DOI 10.1021/acs.orglett.7b00961

    View details for PubMedID 28467706

  • Contemporaneous Dual Catalysis: Aldol Products from Non-Carbonyl Substrates. Chemistry (Weinheim an der Bergstrasse, Germany) Trost, B. M., Tracy, J. S. 2015; 21 (43): 15108-15112

    View details for DOI 10.1002/chem.201502973

    View details for PubMedID 26334442