Direct Enantio- and Diastereoselective Vinylogous Addition of Butenolides to Chromones Catalyzed by Zn-ProPhenol
Journal of the American Chemical Society
View details for DOI 10.1021/jacs.8b13367
Carbon-Nitrogen Bond Formation via the Vanadium Oxo Catalyzed Sigmatropic Functionalization of Allenols.
2017; 19 (10): 2630-2633
A vanadium catalyzed 1,3-rearrangement of allenols to form transient vanadium enolates that selectively couple with electrophilic nitrogen sources is reported even in the presence of competing simple protonation and Alder-ene pathways. Hydrazine products can be cyclized in a 6-endo-trig fashion which, upon reductive cleavage of the N-N bond, yield 1,4-diamines. Additionally, cleavage of the N-N bond before cyclization can be achieved to form β-hydroxy amines, a common structural motif of biologically active compounds.
View details for DOI 10.1021/acs.orglett.7b00961
View details for PubMedID 28467706
- Contemporaneous Dual Catalysis: Aldol Products from Non-Carbonyl Substrates. Chemistry (Weinheim an der Bergstrasse, Germany) 2015; 21 (43): 15108-15112