Doctor of Philosophy, Stanford University, Physics (2015)
Bachelor of Arts, Columbia University, Physics and Mathematics
Noah Rosenberg, Postdoctoral Faculty Sponsor
Individual Identifiability Predicts Population Identifiability in Forensic Microsatellite Markers.
2016; 26 (7): 935-942
Highly polymorphic genetic markers with significant potential for distinguishing individual identity are used as a standard tool in forensic testing [1, 2]. At the same time, population-genetic studies have suggested that genetically diverse markers with high individual identifiability also confer information about genetic ancestry [3-6]. The dual influence of polymorphism levels on ancestry inference and forensic desirability suggests that forensically useful marker sets with high levels of individual identifiability might also possess substantial ancestry information. We study a standard forensic marker set-the 13 CODIS loci used in the United States and elsewhere [2, 7-9]-together with 779 additional microsatellites , using direct population structure inference to test whether markers with substantial individual identifiability also produce considerable information about ancestry. Despite having been selected for individual identification and not for ancestry inference , the CODIS markers generate nontrivial model-based clustering patterns similar to those of other sets of 13 tetranucleotide microsatellites. Although the CODIS markers have relatively low values of the FST divergence statistic, their high heterozygosities produce greater ancestry inference potential than is possessed by less heterozygous marker sets. More generally, we observe that marker sets with greater individual identifiability also tend toward greater population identifiability. We conclude that population identifiability regularly follows as a byproduct of the use of highly polymorphic forensic markers. Our findings have implications for the design of new forensic marker sets and for evaluations of the extent to which individual characteristics beyond identification might be predicted from current and future forensic data.
View details for DOI 10.1016/j.cub.2016.01.065
View details for PubMedID 26996508
- Ab initio multiple spawning on laser-dressed states: a study of 1,3-cyclohexadiene photoisomerization via light-induced conical intersections JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS 2015; 48 (16)
- Enhancement of strong-field multiple ionization in the vicinity of the conical intersection in 1,3-cyclohexadiene ring opening JOURNAL OF CHEMICAL PHYSICS 2013; 139 (18)
Transient X-Ray Fragmentation: Probing a Prototypical Photoinduced Ring Opening
PHYSICAL REVIEW LETTERS
2012; 108 (25)
We report the first study of UV-induced photoisomerization probed via core ionization by an x-ray laser. We investigated x-ray ionization and fragmentation of the cyclohexadiene-hexatriene system at 850 eV during the ring opening. We find that the ion-fragmentation patterns evolve over a picosecond, reflecting a change in the state of excitation and the molecular geometry: the average kinetic energy per ion fragment and H(+)-ion count increase as the ring opens and the molecule elongates. We discuss new opportunities for molecular photophysics created by optical pump x-ray probe experiments.
View details for DOI 10.1103/PhysRevLett.108.253006
View details for Web of Science ID 000305569100005
View details for PubMedID 23004597
Control of 1,3-Cyclohexadiene Photoisomerization Using Light-Induced Conical Intersections
JOURNAL OF PHYSICAL CHEMISTRY A
2012; 116 (11): 2758-2763
We have studied the photoinduced isomerization from 1,3-cyclohexadiene to 1,3,5-hexatriene in the presence of an intense ultrafast laser pulse. We find that the laser field maximally suppresses isomerization if it is both polarized parallel to the excitation dipole and present 50 fs after the initial photoabsorption, at the time when the system is expected to be in the vicinity of a conical intersection that mediates this structural transition. A modified ab initio multiple spawning (AIMS) method shows that the laser induces a resonant coupling between the excited state and the ground state, i.e., a light-induced conical intersection. The theory accounts for the timing and direction of the effect.
View details for DOI 10.1021/jp208384b
View details for Web of Science ID 000301766500022
View details for PubMedID 22082319
Ultrafast ring opening in 1,3-cyclohexadiene investigated by simplex-based spectral unmixing
JOURNAL OF CHEMICAL PHYSICS
2012; 136 (5)
We use spectral unmixing to determine the number of transient photoproducts and to track their evolution following the photo-excitation of 1,3-cyclohexadiene (CHD) to form 1,3,5-hexatriene (HT) in the gas phase. The ring opening is initiated with a 266 nm ultraviolet laser pulse and probed via fragmentation with a delayed intense infrared 800 nm laser pulse. The ion time-of-flight (TOF) spectra are analyzed with a simplex-based spectral unmixing technique. We find that at least three independent spectra are needed to model the transient TOF spectra. Guided by mathematical and physical constraints, we decompose the transient TOF spectra into three spectra associated with the presence of CHD, CHD(+), and HT, and show how these three species appear at different times during the ring opening.
View details for DOI 10.1063/1.3681258
View details for Web of Science ID 000300547200020
View details for PubMedID 22320738
Interactions between individual carbon nanotubes studied by Rayleigh scattering spectroscopy
PHYSICAL REVIEW LETTERS
2006; 96 (16)
The electronic properties of single-walled carbon nanotubes (SWNTs) are altered by intertube coupling whenever bundles are formed. These effects are examined experimentally by applying Rayleigh scattering spectroscopy to probe the optical transitions of given individual SWNTs in their isolated and bundled forms. The transition energies of SWNTs are observed to undergo redshifts of tens of meVs upon bundling with other SWNTs. These intertube coupling effects can be understood as arising from the mutual dielectric screening of SWNTs in a bundle.
View details for DOI 10.1103/PhysRevLett.96.167401
View details for Web of Science ID 000237156700068
View details for PubMedID 16712273