- Photon catalysis of deuterium iodide photodissociation PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2019; 21 (26): 14195–204
Nonresonant photons catalyze photodissociation of phenol.
Journal of the American Chemical Society
Phenol represents an ideal polyatomic system for demonstrating photon catalysis because of its large polarizability, well-characterized excited-state potential energy surfaces, and nonadiabatic dissociation dynamics. A nonresonant IR pulse (1064 nm) supplies a strong electric field (εo = 4 x 107 V/cm) during the photolysis of isolated phenol (C6H5OH) molecules to yield C6H5O + H near two known energetic thresholds: the S1/S2 conical intersection and the S1 - S0 origin. H-atom speed distributions show marked changes in the relative contributions of dissociative pathways in both cases, compared to the absence of the nonresonant IR pulse. Results indicate that nonresonant photons lower the activation barrier for some pathways relative to others by dynamically Stark shifting the excited-state potential energy surfaces rather than aligning molecules in the strong electric field. Theoretical calculations offer support for the experimental interpretation.
View details for PubMedID 30571915
Effect of the application of a non-resonant electric field on the photodissociation dynamics of HBr
AMER CHEMICAL SOC. 2017
View details for Web of Science ID 000430568502311
Polypyrrole nanoparticles for tunable, pH-sensitive and sustained drug release
2015; 7 (21): 9497-9504
We report the development of a generalized pH-sensitive drug delivery system that can release any charged drug preferentially at the pH range of interest. Our system is based on polypyrrole nanoparticles (PPy NPs), synthesized via a simple one-step microemulsion technique. These nanoparticles are highly monodisperse, stable in solution over the period of a month, and have good drug loading capacity (∼15 wt%). We show that PPy NPs can be tuned to release drugs at both acidic and basic pH by varying the pH, the charge of the drug, as well as by adding small amounts of charged amphiphiles. Moreover, these NPs may be delivered locally by immobilizing them in a hydrogel. Our studies show encapsulation within a calcium alginate hydrogel results in sustained release of the incorporated drug for more than 21 days. Such a nanoparticle-hydrogel composite drug delivery system is promising for treatment of long-lasting conditions such as cancer and chronic pain which require controlled, localized, and sustained drug release.
View details for DOI 10.1039/c5nr02196k
View details for Web of Science ID 000354983100021
View details for PubMedID 25931037