Bio


General Surgery Resident (2017-) in professional development time. MS in Epidemiology & Clinical Research (2019-2020), and Biomedical Informatics (2020-). Ex-president of SWAT (Surgeons Writing About Trauma).

My passions:
1) Re-evaluating dogma with data
2) Reducing the data to bedside gap

Honors & Awards


  • Division of General Surgery Resident Professional Development Award, Stanford Department of Surgery (2020, 2021)
  • CWIS-KLS Martin Resident Research Fellowship in Chest Wall Injury Outcomes, Chest Wall Injury Society (2020)
  • Neil and Claudia Doerhoff Scholar, Neil and Claudia Doerhoff fund (2019)
  • Travel Scholarship, American Association for the Surgery of Trauma (2018)
  • Vascular Surgery Intern of the Year, Stanford Department of Surgery (2018)
  • Best Medical Student Research Award, Emile F. Holman Lecture & Research Day (2017)
  • Trainee Award, Technological Innovations in Immunology, American Association of Immunologists (2016)
  • Best Basic Science Research, World Korean Medical Organization (2014)
  • Best Cultural Essay, World Korean Medical Organization (2014)
  • Medical Scholars Award, Stanford University School of Medicine (2014)
  • Young Innovator Award, American Society of Transplantation (2014)

Boards, Advisory Committees, Professional Organizations


  • Research Committee, Chest Wall Injury Society (2021 - Present)
  • Provisional Member, Eastern Association for the Surgery of Trauma (2021 - Present)
  • Associate Member, Society of Asian Academic Surgeons (2020 - Present)
  • Candidate member, Association for Academic Surgery (2020 - Present)
  • Member, American College of Surgeons (2016 - Present)
  • Rapid reponse team lead, Resident Safety Council, Stanford Healthcare (2019 - 2020)
  • Member, Gold Humanism Honor Society (2016 - Present)
  • Member, American Association of Immunologists (2015 - 2017)

Membership Organizations


Professional Education


  • Master of Science, Stanford University, EPIDM-MS (2021)
  • Master of Science, Stanford University, Biomedical Informatics, expected 2021
  • Internship (General Surgery), Stanford University
  • Doctor of Medicine, Stanford University, MED-MD (2017)
  • Bachelor of Science, Cornell University, Policy Analysis and Management (2013)

All Publications


  • Citation Inaccuracies in Influential Surgical Journals. JAMA surgery Choi, J., Gupta, A., Kaghazchi, A., Htwe, T. S., Baiocchi, M., Spain, D. A. 2021

    View details for DOI 10.1001/jamasurg.2021.1445

    View details for PubMedID 34037684

  • Rib Fracture Frailty Index: A Risk-Stratification Tool for Geriatric Patients with Multiple Rib Fractures. The journal of trauma and acute care surgery Choi, J., Marafino, B. J., Vendrow, E. B., Tennakoon, L., Baiocchi, M., Spain, D. A., Forrester, J. D. 2021

    Abstract

    Rib fractures are consequential injuries for geriatric patients (age ≥ 65 years). Although age and injury patterns drive many rib fracture management decisions, the impact of frailty-which baseline conditions affect rib fracture-specific outcomes-remains unclear for geriatric patients. We aimed to develop and validate the Rib Fracture Frailty (RFF) Index, a practical risk-stratification tool specific for geriatric patients with rib fractures. We hypothesized that a compact list of frailty markers can accurately risk stratify clinical outcomes after rib fractures.We queried nationwide US admission encounters of geriatric patients admitted with multiple rib fractures from 2016-2017. Partitioning-around-medoids clustering identified a development subcohort with previously-validated frailty characteristics. Ridge regression with penalty for multicollinearity aggregated baseline conditions most prevalent in this frail subcohort into RFF scores. Regression models with adjustment for injury severity, sex, and age assessed associations between frailty risk categories (low, medium, and high) and inpatient outcomes among validation cohorts (OR [95%CI]). We report results according to Transparent Reporting of Multivariable Prediction Model for Individual Prognosis guidelines.Development cohort (N = 55,540) cluster analysis delineated thirteen baseline conditions constituting the RFF Index. Among external validation cohort (N = 77,710), increasing frailty risk (low [reference group], moderate, high) was associated with stepwise worsening adjusted odds of mortality (1.5[1.2-1.7], 3.5 [3.0-4.0]), intubation (2.4[1.5-3.9], 4.7[3.1-7.5]), hospitalization ≥5 days (1.4[1.3-1.5], 1.8[1.7-2.0]), and disposition to home (0.6[0.5-0.6], 0.4[0.3-0.4]). Locally weighted scatterplot smoothing showed correlations between increasing RFF scores and worse outcomes.RFF Index is a practical frailty risk-stratification tool for geriatric patients with multiple rib fractures. The mobile app we developed may facilitate rapid implementation and further validation of RFF Index at the bedside.level III, prognostic study.

    View details for DOI 10.1097/TA.0000000000003390

    View details for PubMedID 34446653

  • Practical Computer Vision Application to Compute Total Body Surface Area Burn: Reappraising a Fundamental Burn Injury Formula in the Modern Era. JAMA surgery Choi, J., Patil, A., Vendrow, E., Touponse, G., Aboukhater, L., Forrester, J. D., Spain, D. A. 2021

    Abstract

    Critical burn management decisions rely on accurate percent total body surface area (%TBSA) burn estimation. Existing %TBSA burn estimation models (eg, Lund-Browder chart and rule of nines) were derived from a linear formula and a limited number of individuals a century ago and do not reflect the range of body habitus of the modern population.To develop a practical %TBSA burn estimation tool that accounts for exact burn injury pattern, sex, and body habitus.This population-based cohort study evaluated the efficacy of a computer vision algorithm application in processing an adult laser body scan data set. High-resolution surface anthropometry laser body scans of 3047 North American and European adults aged 18 to 65 years from the Civilian American and European Surface Anthropometry Resource data set (1998-2001) were included. Of these, 1517 participants (49.8%) were male. Race and ethnicity data were not available for analysis. Analyses were conducted in 2020.The contributory %TBSA for 18 body regions in each individual. Mobile application for real-time %TBSA burn computation based on sex, habitus, and exact burn injury pattern.Of the 3047 individuals aged 18 to 65 years for whom body scans were available, 1517 (49.8%) were male. Wide individual variability was found in the extent to which major body regions contributed to %TBSA, especially in the torso and legs. Anterior torso %TBSA increased with increasing body habitus (mean [SD], 15.1 [0.9] to 19.1 [2.0] for male individuals; 15.1 [0.8] to 18.0 [1.7] for female individuals). This increase was attributable to increase in abdomen %TBSA (mean [SD], 5.3 [0.7] to 8.7 [1.8]) among male individuals and increase in abdomen (mean [SD], 4.6 [0.6] to 6.8 [1.7]) and pelvis (mean [SD], 1.5 [0.2] to 2.9 [0.9]) %TBSAs among female individuals. For most body regions, Lund-Browder chart and rule of nines estimates fell outside the population's measured interquartile ranges. The mobile application tested in this study, Burn Area, facilitated accurate %TBSA burn computation based on exact burn injury pattern for 10 sex and body habitus-specific models.Computer vision algorithm application to a large laser body scan data set may provide a practical tool that facilitates accurate %TBSA burn computation in the modern era.

    View details for DOI 10.1001/jamasurg.2021.5848

    View details for PubMedID 34817552

  • Safety of Foregoing Operation for Small Bowel Obstruction in the Virgin Abdomen: Systematic Review and Meta-Analysis. Journal of the American College of Surgeons Choi, J. n., Fisher, A. T., Mulaney, B. n., Anand, A. n., Carlos, G. n., Stave, C. D., Spain, D. A., Weiser, T. G. 2020

    Abstract

    Our objective was to assess the safety of foregoing surgery in patients without abdominopelvic surgery history presenting with small bowel obstruction (SBO). Classic dogma has counseled early surgical intervention for small bowel obstruction (SBO) in the virgin abdomen - patients without abdominopelvic surgery history - given their presumed higher risk of malignant or potentially catastrophic etiologies compared to those who underwent prior abdominal operations. The term virgin abdomen was coined before widespread use of computed tomography, which now elucidates many SBO etiologies. Despite recent efforts to re-evaluate clinical management standards, the prevalence of SBO etiologies in the virgin abdomen and the current management landscape (non-operative vs operative) in these patients remain unclear. Our random-effects meta-analysis of six studies including 442 patients found the prevalence of malignant etiologies in patients without abdominopelvic surgery history presenting with SBO varied from 7.7% [95% CI:3.0-14.1] to 13.4% [95% CI:7.6-20.3] on sensitivity analysis. Most malignant etiologies were not suspected prior to surgery. De novo adhesions (54%) were the most common etiology. Over half of patients underwent a trial of non-operative management, which often failed. Subgroups of patients likely have variable risk profiles for underlying malignant etiologies, yet no study had consistent follow-up data and we did not find convincing evidence that foregoing operative management altogether in this population can be generally recommended.

    View details for DOI 10.1016/j.jamcollsurg.2020.06.010

    View details for PubMedID 32574687

  • Nationwide Cost-Effectiveness Analysis of Surgical Stabilization of Rib Fractures by Flail Chest Status and Age Groups. The journal of trauma and acute care surgery Choi, J. n., Mulaney, B. n., Laohavinij, W. n., Trimble, R. n., Tennakoon, L. n., Spain, D. A., Salomon, J. A., Goldhaber-Fiebert, J. D., Forrester, J. D. 2020

    Abstract

    SSRF is increasingly utilized to manage patients with rib fractures. Benefits of performing SSRF appear variable and the procedure is costly, necessitating cost-effectiveness analysis for distinct subgroups. We aimed to assess the cost-effectiveness of surgical stabilization of rib fractures (SSRF) vs non-operative management among patients with rib fractures aged <65 vs ≥65 years, with vs without flail chest. We hypothesized that compared to non-operative management, SSRF is cost-effective only for patients with flail chest.This economic evaluation used a decision-analytic Markov model with a lifetime time horizon incorporating US population-representative inputs to simulate benefits and risks of SSRF compared to non-operative management. We report quality-adjusted life-years (QALYs), costs, and incremental cost-effectiveness ratios (ICERs). Deterministic and probabilistic sensitivity analyses accounted for most plausible clinical scenarios.Compared to non-operative management, SSRF was cost-effective for patients with flail chest at willingness-to-pay threshold of $150,000/QALY gained. SSRF cost $25,338 and $123,377/QALY gained for those with flail chest aged <65 and ≥65 years, respectively. SSRF was not cost-effective for patients without flail chest; costing $172,704 and $243,758/QALY gained for those aged <65 and ≥65 years, respectively. One-way sensitivity analyses showed that under most plausible scenarios, SSRF remained cost-effective for subgroups with flail chest and non-operative management remained cost-effective for patients aged >65 without flail chest. Probability that SSRF is cost-effective ranged from 98% among patients aged <65 with flail chest to 35% among patients aged ≥65 without flail chest.SSRF is cost effective for patients with flail chest. SSRF may be cost-effective in some patients without flail chest, but delineating these patients requires further study.level II.

    View details for DOI 10.1097/TA.0000000000003021

    View details for PubMedID 33559982

  • Surgical Stabilization of Rib Fracture to Mitigate Pulmonary Complication and Mortality: A Systematic Review and Bayesian Meta-Analysis. Journal of the American College of Surgeons Choi, J. n., Gomez, G. I., Kaghazchi, A. n., Borghi, J. A., Spain, D. A., Forrester, J. D. 2020

    View details for DOI 10.1016/j.jamcollsurg.2020.10.022

    View details for PubMedID 33212228

  • Prospective Study of Short-Term Quality-of-Life After Traumatic Rib Fractures. The journal of trauma and acute care surgery Choi, J. n., Khan, S. n., Hakes, N. A., Carlos, G. n., Seltzer, R. n., Jaramillo, J. D., Spain, D. A. 2020

    Abstract

    Post-discharge convalescence after traumatic rib fractures remains unclear. We hypothesized that patients with rib fractures, even as an isolated injury, have associated poor QoL after discharge.We prospectively enrolled adult patients at our Level I trauma center with rib fractures between July 2019 and January 2020. We assessed QoL at 1 and 3-months after discharge using the Trauma-specific Quality-of-Life (T-QoL: 43-question survey evaluating five QoL domains on a four-point Likert scale. "4" indicates optimal and "1" worst QoL) and supplementary questionnaires. We used generalized estimating equations to assess T-QoL score trends over time and effect of age, sex, injury pattern, self-perceived injury severity, and injury severity score.We enrolled 139 patients (108 completed the first and 93 completed both surveys). Three months after discharge, 33% of patients were not working at pre-injury capacity and 7% were still using opioid analgesia. Suffering rib fractures most impacted recovery and resilience (T-QoL score, mean [robust standard error] at 1-month: 2.7[0.1], 3-months: 3.0[0.1]) and physical well-being domains (1-month: 2.5[0.1]; 3-months 2.9[0.1]). QoL improved over time across all domains. Compared with patients who perceived their injuries as mild/moderate, patients who perceived their injuries as severe/very severe reported worse T-QoL scores across all domains. In contrast, injury severity score did not affect QoL. Patients aged ≥65 years (-0.6[0.1]) and females (-0.6[0.2]) reported worse functional engagement compared with those aged ≤65 years and males, respectively.We found that patients with traumatic rib fractures experience suboptimal QoL after discharge. QoL improved over time, but even three months after discharge, patients reported challenges performing activities of daily living, slower-than-expected recovery, and not returning to work at pre-injury capacity. Perception of injury severity had a large effect on QoL. Patients with rib fractures may benefit from close short-term follow-up.Prognostic and Epidemiological LEVEL OF EVIDENCE: Level III.

    View details for DOI 10.1097/TA.0000000000002917

    View details for PubMedID 32925583

  • Pain Scores in Geriatric vs Nongeriatric Patients With Rib Fractures. JAMA surgery Choi, J. n., Khan, S. n., Zamary, K. n., Tennakoon, L. n., Spain, D. A. 2020

    View details for DOI 10.1001/jamasurg.2020.1933

    View details for PubMedID 32609366

  • Outcome-specific Injury Scores (OSIS): Development and Validation of Tailored Prediction Tools for Injured Older Adults Choi, J., Tennakoon, L., Spain, D. A., Staudenmayer, K. L. ELSEVIER SCIENCE INC. 2021: E74
  • Associations of Hearing Loss and Hearing Aid Use with Hospitalization in the Elderly Thai, A., Khan, S. I., Choi, J., Megwalu, U. C. ELSEVIER SCIENCE INC. 2021: S170-S171
  • Traumatic Injury and Death Among Law Enforcement Officers Patil, A., Tennakoon, L., Choi, J., Hakes, N., Spain, D. A., Tung, J. ELSEVIER SCIENCE INC. 2021: E94
  • Scoping review of traumatic hemothorax: Evidence and knowledge gaps, from diagnosis to chest tube removal. Surgery Choi, J., Villarreal, J., Andersen, W., Min, J. G., Touponse, G., Wong, C., Spain, D. A., Forrester, J. D. 2021

    Abstract

    BACKGROUND: Traumatic hemothorax is a common injury that invites diagnostic and management strategy debates. Evidence-based management has been associated with improved care efficiency. However, the literature abounds with long-debated, re-emerging, and new questions. We aimed to consolidate up-to-date evidence on traumatic hemothoraces, focusing on clinical conundra debated in literature.METHODS: We conducted a scoping review of 21 clinical conundra in traumatic hemothorax diagnosis and management according to PRISMA-ScR guidelines. Experimental and observational studies evaluating patients (aged ≥18 years) with traumatic hemothoraces were identified through database searches (PubMed, EMBASE, Web of Science, Cochrane Library; database inception to Sep, 26 2020) and bibliography reviews of selected articles. Three reviewers screened and selected articles using standardized forms.RESULTS: We screened 1,440 articles for eligibility, of which 71 met criteria for synthesis. The review comprises 6 sections: (1) Presumptive antibiotics before tube thoracostomy; (2) Initial diagnostic and intervention decisions; (3) Chest tubes; (4) Retained hemothoraces; (5) Delayed hemothoraces; and (6) Chest tube removal). The 21 conundra across these sections follow the format of a question, our recommendation based on interpretation of available evidence, and succinct rationale. Rationale sections detail knowledge gaps and opportunities for future research.CONCLUSION: Even practices engrained into surgical dogma, such as obtaining chest x-rays after inserting or removing chest tubes and mandating operation for patients who develop chest tube output above a certain threshold, deserve re-evaluation. Some knowledge gaps require rigorous future investigation; sound clinical judgment can likely supplement others.

    View details for DOI 10.1016/j.surg.2021.03.030

    View details for PubMedID 33888318

  • The impact of trauma systems on patient outcomes. Current problems in surgery Choi, J., Carlos, G., Nassar, A. K., Knowlton, L. M., Spain, D. A. 2021; 58 (1): 100840

    View details for DOI 10.1016/j.cpsurg.2020.100840

    View details for PubMedID 33431135

  • Evidence-based surgery for laparoscopic appendectomy: A stepwise systematic review. Surgery open science Bessoff, K. E., Choi, J., Wolff, C. J., Kashikar, A., Carlos, G. M., Caddell, L., Khan, R. I., Stave, C. D., Spain, D. A., Forrester, J. D. 2021; 6: 29-39

    Abstract

    Appendectomy is a common emergency surgery performed globally. Despite the frequency of laparoscopic appendectomy, consensus does not exist on the best way to perform each procedural step. We identified literature on key intraoperative steps to inform best technical practice during laparoscopic appendectomy.Research questions were framed using the population, indication, comparison, outcome (PICO) format for 6 key operative steps of laparoscopic appendectomy: abdominal entry, placement of laparoscopic ports, division of mesoappendix, division of appendix, removal of appendix, and fascial closure. These questions were used to build literature queries in PubMed, EMBASE, and the Cochrane Library databases. Evidence quality and certainty was assessed using Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) definitions.Recommendations were rendered for 6 PICO questions based on 28 full length articles. Low quality evidence favors direct trocar insertion for abdominal entry and establishment of pneumoperitoneum. Single port appendectomy results in improved cosmesis with unclear clinical implications. There was insufficient data to determine the optimal method of appendiceal stump closure, but use of a specimen extraction bag reduces rates of superficial surgical site infection and intra-abdominal abscess. Port sites made with radially dilating trocars are less likely to necessitate closure and are less likely to result in port site hernia. When port sites are closed, a closure device should be used.Key operative steps of laparoscopic appendectomy have sufficient data to encourage standardized practice.

    View details for DOI 10.1016/j.sopen.2021.08.001

    View details for PubMedID 34604728

    View details for PubMedCentralID PMC8473533

  • Intercostal Nerve Cryoablation during Surgical Stabilization of Rib Fractures. The journal of trauma and acute care surgery Choi, J., Min, J. G., Jopling, J. K., Meshkin, S., Bessoff, K. E., Forrester, J. D. 2021

    Abstract

    Intercostal nerve cryoablation (IC) offers potential for targeted and durable analgesia for patients with traumatic rib fractures. Our pilot study aimed to investigate thoracoscopic IC's safety, feasibility, and preliminary efficacy for patients undergoing surgical stabilization of rib fractures (SSRF). We hypothesized concurrent SSRF-IC is a safe and feasible procedure without immediate or long-term complications.We retrospectively evaluated patients aged ≥18 years who underwent SSRF (with or without IC) for acute rib fractures at our Level I trauma center between 1 September 2019 and 30 September 2020. We performed IC under thoracoscopic visualization (-70 °C for 2 minutes per intercostal nerve bundle). Among patients whose only operative procedure during hospitalization was SSRF, we evaluated post-SSRF length of stay, operative times, opioid requirements (oral morphine equivalents) and pain scores (Numerical Rating Scale). Generalized estimating equations compared SSRF and SSRF-IC group outcomes (population mean[robust standard error]). We assessed long-term outcomes of patients who underwent SSRF-IC.Thirty-four patients (144 ribs) underwent SSRF; of these, 20 patients (135 ribs) underwent SSRF-IC. Patients who did and did not undergo concurrent IC had no significant difference demographic, injury, or hospitalization characteristics. Among 20 patients who did not undergo other operations, 12 underwent SSRF-IC. We did not find significant difference between SSRF and SSRF-IC groups' median operative times or post-SSRF length of stay. Compared to SSRF group, SSRF-IC group did not have statistically significant change in pain score (0.2[1.5] lower) or opioid use (43.9[86.1] mg/day greater) between 12-hours before SSRF and last 24 admission hours. Among 17 SSRF-IC patients who followed-up post-discharge (median[range]: 160[9-357] days), one reported mild chest wall paresthesia; no other complications were reported.Pilot study performing 135 intercostal nerve cryoablations on 20 patients suggests IC is safe and feasible for patients undergoing SSRF. Evaluating IC's analgesic efficacy for rib fractures requires further study.Level IV, prognostic and epidemiological study.

    View details for DOI 10.1097/TA.0000000000003391

    View details for PubMedID 34446656

  • Systematic Review and Meta-Analysis of Hardware Failure in Surgical Stabilization of Rib Fractures: Who, What, When, Where, and Why? The Journal of surgical research Choi, J., Kaghazchi, A., Sun, B., Woodward, A., Forrester, J. D. 2021; 268: 190-198

    Abstract

    Surgical stabilization of rib fractures (SSRF) is increasingly used to reduce pulmonary complications and death among patients with rib fractures. However, the five Ws of hardware failure -who, what, when, where, and why- remains unclear. We aimed to synthesize available evidence on the five Ws and outline future research agenda for mitigating hardware failure.Experimental and observational studies published between 2009 and 2020 evaluating adults undergoing SSRF for traumatic rib fractures underwent evidence synthesis. We performed random effects meta-analysis of cohort/consecutive case studies. We calculated pooled prevalence of SSRF hardware failures using Freeman-Tukey double arcsine transformation and assessed study heterogeneity using DerSimonian-Laird estimation. We performed meta-regression with rib fracture acuity (acute or chronic) and hardware type (metal plate or not metal plate) as moderators.Twenty-nine studies underwent qualitative synthesis and 24 studies (2404 SSRF patients) underwent quantitative synthesis. Pooled prevalence of hardware failure was 4(3-7)%. Meta-regression showed fracture acuity was a significant moderator (P = 0.002) of hardware failure but hardware type was not (P = 0.23). Approximately 60% of patients underwent hardware removal after hardware failure. Mechanical failures were the most common type of hardware failure, followed by hardware infections, pain/discomfort, and non-union. Timing of hardware failure after surgery was highly variable, but 87% of failures occurred after initial hospitalization. Mechanical failures was attributed to technical shortcomings (i.e. short plate length) or excessive force on the thoracic cavity.SSRF hardware failure is an uncommon complication. Not all hardware failures are consequential, but insufficient individual patient data precluded characterizing where and why hardware failures occur. Minimizing SSRF hardware failure requires concerted research agenda to expand on the paucity of existing evidence.

    View details for DOI 10.1016/j.jss.2021.06.054

    View details for PubMedID 34333416

  • Efficacy of intercostal cryoneurolysis as an analgesic adjunct for chest wall pain after surgery or trauma: a systematic review Trauma Surgery & Acute Care Open Cha, P. I., Min, J. G., Patil, A., Choi, J., Kothary, N. N., Forrester, J. D. 2021: e000690
  • Practical computer vision application to detect hip fractures on pelvic X-rays: a bi-institutional study. Trauma surgery & acute care open Choi, J. n., Hui, J. Z., Spain, D. n., Su, Y. S., Cheng, C. T., Liao, C. H. 2021; 6 (1): e000705

    Abstract

    Pelvic X-ray (PXR) is a ubiquitous modality to diagnose hip fractures. However, not all healthcare settings employ round-the-clock radiologists and PXR sensitivity for diagnosing hip fracture may vary depending on digital display. We aimed to validate a computer vision algorithm to detect hip fractures across two institutions' heterogeneous patient populations. We hypothesized a convolutional neural network algorithm can accurately diagnose hip fractures on PXR and a web application can facilitate its bedside adoption.The development cohort comprised 4235 PXRs from Chang Gung Memorial Hospital (CGMH). The validation cohort comprised 500 randomly sampled PXRs from CGMH and Stanford's level I trauma centers. Xception was our convolutional neural network structure. We randomly applied image augmentation methods during training to account for image variations and used gradient-weighted class activation mapping to overlay heatmaps highlighting suspected fracture locations.Our hip fracture detection algorithm's area under the receiver operating characteristic curves were 0.98 and 0.97 for CGMH and Stanford's validation cohorts, respectively. Besides negative predictive value (0.88 Stanford cohort), all performance metrics-sensitivity, specificity, predictive values, accuracy, and F1 score-were above 0.90 for both validation cohorts. Our web application allows users to upload PXR in multiple formats from desktops or mobile phones and displays probability of the image containing a hip fracture with heatmap localization of the suspected fracture location.We refined and validated a high-performing computer vision algorithm to detect hip fractures on PXR. A web application facilitates algorithm use at the bedside, but the benefit of using our algorithm to supplement decision-making is likely institution dependent. Further study is required to confirm clinical validity and assess clinical utility of our algorithm.III, Diagnostic tests or criteria.

    View details for DOI 10.1136/tsaco-2021-000705

    View details for PubMedID 33912689

    View details for PubMedCentralID PMC8031685

  • Complication to consider: delayed traumatic hemothorax in older adults Trauma Surgery Acute Care Open Choi, J., Anand, A., Sborov, K. D., Walton, W., Chow, L., Guillamondegui, O., Dennis, B. M., Spain, D., Staudenmayer, K. 2021
  • Heterogeneity in managing rib fractures across non-trauma and level I, II, and III trauma centers. American journal of surgery Choi, J. n., Kaghazchi, A. n., Dickerson, K. L., Tennakoon, L. n., Spain, D. A., Forrester, J. D. 2021

    Abstract

    We aimed to elucidate management patterns and outcomes of high-risk patients with rib fractures (elderly or flail chest) across non-trauma and trauma centers. We hypothesized highest-capacity (level I) centers would have best outcomes for high-risk patients.We queried the 2016 National Emergency Department Sample to identify adults presenting with rib fractures. Multivariable regression assessed ED and inpatient events across non-trauma and level III/II/I trauma centers.Among 504,085 rib fracture encounters, 46% presented to non-trauma centers. Elderly patients with multiple rib fractures had stepwise increase in inpatient admission odds and stepwise decrease in pneumonia odds at higher-capacity trauma centers compared to non-trauma centers. Among patients with flail chest, odds of undergoing surgical stabilization (SSRF) increased at trauma centers. Undergoing SSRF was associated with reduced mortality but remained underutilized.Half of patients with rib fractures present to non-trauma centers. Nationwide care-optimization for high-risk patients requires further effort.

    View details for DOI 10.1016/j.amjsurg.2021.02.013

    View details for PubMedID 33612257

  • Early National Landscape of Surgical Stabilization of Sternal Fractures. World journal of surgery Choi, J. n., Khan, S. n., Syed, M. n., Tennakoon, L. n., Forrester, J. D. 2021

    Abstract

    Operative management of chest wall injuries aims to restore respiratory mechanics and mitigate pulmonary complications. Extensive studies support surgical stabilization of rib fractures (SSRF) for select patients, but role for surgical stabilization of sternal fractures (SSSF) remains unclear. We aimed to understand national prevalence of SSSF and compare outcomes after surgical stabilization and non-operative management of sternal fractures.We retrospectively analyzed adult patients (age ≥ 18 years) admitted with sternal fractures after blunt trauma using the 2016 National Trauma Data Bank. We compared odds of inpatient mortality, pneumonia, and respiratory failure for propensity score matched patients (4:1) who underwent non-operative management vs SSSF. We characterized subgroup of patients with concurrent rib and sternal fractures who underwent concomitant SSRF-SSSF.We identified 14,760 encounters of adults admitted with sternal fractures; 270 (1.8%) underwent SSSF. Compared to matched patients who underwent non-operative management, patients who underwent SSSF had lower odds of mortality (OR [95%CI]: 0.19 [0.06-0.62], p = 0.006). Adjusted for trauma center level, Mantel-Haenszel mortality odds remained lower for patients who underwent SSSF. Odds of pneumonia and respiratory failure were similar between matched groups. Among 46% of patients who had concomitant rib fractures, 0.3% (n = 18) underwent concurrent SSRF-SSSF and these patients survived hospitalization without pneumonia or respiratory failure.A vast majority of patients who suffer sternal fractures undergo non-operative management. Potential mortality benefit of SSSF and concurrent SSRF-SSSF's role for commonly concomitant rib and sternal fractures deserve further study. Our preliminary findings call for delineating heterogeneity of sternal fractures and establishing consensus SSSF indications.

    View details for DOI 10.1007/s00268-021-06007-5

    View details for PubMedID 33604709

  • Concomitant Sternal Fractures: Harbinger of Worse Pulmonary Complications and Mortality in Patients With Rib Fractures. The American surgeon Choi, J. n., Mulaney, B. n., Sun, B. n., Trimble, R. n., Tennakoon, L. n., Spain, D. A., Forrester, J. D. 2021: 3134821991978

    Abstract

    Sternal and rib fractures are common concomitant injuries. However, the impact of concurrent sternal fractures on clinical outcomes of patients with rib fractures is unclear. We aimed to unveil the pulmonary morbidity and mortality impact of concomitant sternal fractures among patients with rib fractures.We identified adult patients admitted with traumatic rib fractures with vs. without concomitant sternal fractures using the 2012-2014 National Inpatient Sample (NIS). After 2:1 propensity score matching and adjustment for residual imbalances, we compared risk of pulmonary morbidity and mortality between patients with vs. without concomitant sternal fractures. Subgroup analysis in patients with flail chest assessed whether sternal fractures modify the association between undergoing surgical stabilization of rib fractures (SSRF) and pulmonary morbidity or mortality.Of 475 710 encounters of adults admitted with rib fractures, 24 594 (5%) had concomitant sternal fractures. After 2:1 propensity score matching, patients with concomitant sternal fractures had 70% higher risk (95% CI: 50-90% higher, P < 0.001) of undergoing tracheostomy, 40% higher risk (30-50% higher, P <.001) of undergoing intubation, and 20% higher risk of respiratory failure (10-30% higher, P <.001) and mortality (10-40% higher, P =.007). Subgroup analysis of 8600 patients with flail chest showed concomitant sternal fractures did not impact the association between undergoing SSRF and any pulmonary morbidity or mortality.Concomitant sternal fractures are associated with increased risk for pulmonary morbidity and mortality among patients with rib fractures. However, our findings are limited by a binary definition of sternal fractures, which encompasses heterogeneous injury patterns with likely variable clinical relevance.

    View details for DOI 10.1177/0003134821991978

    View details for PubMedID 33522281

  • Incidence and Management of Arterial Vascular Trauma in the US Kashikar, A., Choi, J., Tennakoon, L., Spain, D., Arya, S. ELSEVIER SCIENCE INC. 2020: E263–E264
  • Common, Severe, and Preventable: Agricultural Machinery Trauma in the US Hakes, N. A., Jaramillo, J. D., Choi, J., Spain, D. A., Tennakoon, L., Forrester, J. D. ELSEVIER SCIENCE INC. 2020: E231
  • Review of Facial Trauma Management. The journal of trauma and acute care surgery Choi, J. n., Lorenz, H. P., Spain, D. A. 2020

    Abstract

    Facial trauma afflicts significant morbidity and mortality with potential to compromise critical adjacent structures. Facial trauma management is often entrusted to the hands of the craniofacial surgeon; evidence-based practice may be difficult to distinguish from outdated practice for the non-craniofacial trauma surgeon. We review up-to-date evidence in facial trauma management relevant for trauma surgeons, and highlight areas needing further research.Review.

    View details for DOI 10.1097/TA.0000000000002589

    View details for PubMedID 31972757

  • National readmission rates after surgical stabilization of traumatic rib fractures The Journal of Cardiothoracic Trauma Cha, P. I., Hakes, N. A., Choi, J., Tennakoon, L., Spain, D. A., Forrester, J. D. 2020; 5 (1): 16-21

    View details for DOI 10.4103/jctt.jctt_6_20

  • Prospectively Assigned AAST Grade versus Modified Hinchey Class and Acute Diverticulitis Outcomes. The Journal of surgical research Choi, J. n., Bessoff, K. n., Bromley-Dulfano, R. n., Li, Z. n., Gupta, A. n., Taylor, K. n., Wadhwa, H. n., Seltzer, R. n., Spain, D. A., Knowlton, L. M. 2020

    Abstract

    The American Association for the Surgery of Trauma (AAST) recently developed a classification system to standardize outcomes analyses for several emergency general surgery conditions. To highlight this system's full potential, we conducted a study integrating prospective AAST grade assignment within the electronic medical record.Our institution integrated AAST grade assignment into our clinical workflow in July 2018. Patients with acute diverticulitis were prospectively assigned AAST grades and modified Hinchey classes at the time of surgical consultation. Support vector machine-a machine learning algorithm attuned for small sample sizes-was used to compare the associations between the two classification systems and decision to operate and incidence of complications.67 patients were included (median age of 62 y, 40% male) for analysis. The decision for operative management, hospital length of stay, intensive care unit admission, and intensive care unit length of stay were associated with both increasing AAST grade and increasing modified Hinchey class (all P < 0.001). AAST grade additionally showed a correlation with complication severity (P = 0.02). Compared with modified Hinchey class, AAST grade better predicted decision to operate (88.2% versus 82.4%).This study showed the feasibility of electronic medical record integration to support the full potential of AAST classification system's utility as a clinical decision-making tool. Prospectively assigned AAST grade may be an accurate and pragmatic method to find associations with outcomes, yet validation requires further study.

    View details for DOI 10.1016/j.jss.2020.10.016

    View details for PubMedID 33248670

  • Outcome after surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures and moderate to severe traumatic brain injury (CWIS-TBI). The journal of trauma and acute care surgery Prins, J. T., Van Lieshout, E. M., Ali-Osman, F. n., Bauman, Z. M., Caragounis, E. C., Choi, J. n., Benjamin Christie, D. n., Cole, P. A., DeVoe, W. B., Doben, A. R., Eriksson, E. A., Forrester, J. D., Fraser, D. R., Gontarz, B. n., Hardman, C. n., Hyatt, D. G., Kaye, A. J., Ko, H. J., Leasia, K. N., Leon, S. n., Marasco, S. F., McNickle, A. G., Nowack, T. n., Ogunleye, T. D., Priya, P. n., Richman, A. P., Schlanser, V. n., Semon, G. R., Su, Y. H., Verhofstad, M. H., Whitis, J. n., Pieracci, F. M., Wijffels, M. M. 2020

    Abstract

    Outcomes after surgical stabilization of rib fractures (SSRF) have not been studied in patients with multiple rib fractures and traumatic brain injury (TBI). We hypothesized that SSRF, as compared to nonoperative management, is associated with favorable outcomes in patients with TBI.A multicenter, retrospective cohort study was performed in patients with rib fractures and TBI between January 2012 and July 2019. Patients who underwent SSRF were compared to those managed nonoperatively. The primary outcome was mechanical ventilation-free days. Secondary outcomes were Intensive Care Unit (ICU-LOS) and hospital length of stay (HLOS), tracheostomy, occurrence of complications, neurologic outcome, and mortality. Patients were further stratified into moderate (GCS 9-12) and severe (GCS ≤8) TBI.The study cohort consisted of 456 patients of which 111 (24.3%) underwent SSRF. SSRF was performed at a median of 3 days and SSRF-related complication rate was 3.6%. In multivariable analyses, there was no difference in mechanical ventilation-free days between the SSRF and nonoperative groups. The odds of developing pneumonia (OR 0.59 (95% CI 0.38-0.98), p=0.043) and 30-day mortality (OR 0.32 (95% CI 0.11-0.91), p=0.032) were significantly lower in the SSRF group. Patients with moderate TBI had similar outcome in both groups. In patients with severe TBI, the odds of 30-day mortality was significantly lower after SSRF (0.19 (95% CI 0.04-0.88), p=0.034).In patients with multiple rib fractures and TBI, the mechanical ventilation-free days did not differ between the two treatment groups. In addition, SSRF was associated with a significantly lower risk of pneumonia and 30-day mortality. In patients with moderate TBI, outcome was similar. In patients with severe TBI a lower 30-day mortality was observed. There was a low SSRF-related complication risk. These data suggest a potential role for SSRF in select patients with TBI.Therapeutic, level IV.

    View details for DOI 10.1097/TA.0000000000002994

    View details for PubMedID 33093293

  • Concurrent large bowel obstruction secondary to idiopathic mesenteroaxial gastric volvulus. Trauma surgery & acute care open Anand, A., Choi, J., Jaramillo, J. D., Lau, J. 2020; 5 (1): e000582

    View details for DOI 10.1136/tsaco-2020-000582

    View details for PubMedID 33024829

  • Intravenous lidocaine as a non-opioid adjunct analgesic for traumatic rib fractures. PloS one Choi, J. n., Zamary, K. n., Barreto, N. B., Tennakoon, L. n., Davis, K. M., Trickey, A. W., Spain, D. A. 2020; 15 (9): e0239896

    Abstract

    Pain management is the pillar of caring for patients with traumatic rib fractures. Intravenous lidocaine (IVL) is a well-established non-opioid analgesic for post-operative pain, yet its efficacy has yet to be investigated in trauma patients. We hypothesized that IVL is associated with decreased inpatient opioid requirements among patients with rib fractures.We retrospectively evaluated adult patients presenting to our Level 1 trauma center with isolated chest wall injuries. After 1:1 propensity score matching patients who received vs did not receive IVL, we compared the two groups' average daily opioid use, opioid use in the last 24 hours of admission, and pain scores during admissions hours 24-48. We performed multivariable linear regression for these outcomes (with sensitivity analysis for the opioid use outcomes), adjusting for age as a moderating factor and controlling for hospital length of stay and injury severity.We identified 534 patients, among whom 226 received IVL. Those who received IVL were older and had more serious injury. Compared to propensity-score matched patients who did not receive IVL, patients who received IVL had similar average daily opioid use and pain scores, but 40% lower opioid use during the last 24 hours of admission (p = 0.002). Multivariable regression-with and without sensitivity analysis-did not show an effect of IVL on any outcomes.IVL was crudely associated with decreased opioid requirements in the last 24 hours of admission, the time period associated with opioid use at 90 days post-discharge. However, we did not observe beneficial effects of IVL on multivariable adjusted analyses; we are conducting a randomized control trial to further evaluate IVL's opioid-sparing effects for patients with rib fractures.

    View details for DOI 10.1371/journal.pone.0239896

    View details for PubMedID 32986770

  • Creation and implementation of a novel clinical workflow based on the AAST uniform anatomic severity grading system for emergency general surgery conditions. Trauma surgery & acute care open Bessoff, K. E., Choi, J. n., Bereknyei Merrell, S. n., Nassar, A. K., Spain, D. n., Knowlton, L. M. 2020; 5 (1): e000552

    Abstract

    Emergency general surgery (EGS) conditions encompass a variety of diseases treated by acute care surgeons. The heterogeneity of these diseases limits infrastructure to facilitate EGS-specific quality improvement (QI) and research. A uniform anatomic severity grading system for EGS conditions was recently developed to fill this need. We integrated this system into our clinical workflow and examined its impact on research, surgical training, communication, and patient care.The grading system was integrated into our clinical workflow in a phased fashion through formal education and a written handbook. A documentation template was also deployed in our electronic medical record to prospectively assign severity scores at the time of patient evaluation. Mixed methods including a quantitative survey and qualitative interviews of trainees and attending surgeons were used to evaluate the impact of the new workflow and to identify obstacles to its adoption.We identified 2291 patients presenting with EGS conditions during our study period. The most common diagnoses were small bowel obstruction (n=470, 20.5%), acute cholecystitis (n=384, 16.8%), and appendicitis (n=370, 16.1%). A total of 21 qualitative interviews were conducted. Twenty interviewees (95.2%) had a positive impression of the clinical workflow, citing enhanced patient care and research opportunities. Fifteen interviewees (75.0%) reported the severity grading system was a useful framework for clinical management, with five participants (25.0%) indicating the system was useful to facilitate clinical communication. Participants identified solutions to overcome barriers to adoption of the clinical workflow.The uniform anatomic severity grading system can be readily integrated into a clinical workflow to facilitate prospective data collection for QI and research. The system is perceived as valuable by users. Educational initiatives that focus on increasing familiarity with the system and its benefits will likely improve adoption of the classification system and the clinical workflow that uses it.Level III.

    View details for DOI 10.1136/tsaco-2020-000552

    View details for PubMedID 32953998

    View details for PubMedCentralID PMC7481073

  • Pulmonary contusions in patients with rib fractures: The need to better classify a common injury. American journal of surgery Choi, J. n., Tennakoon, L. n., You, J. G., Kaghazchi, A. n., Forrester, J. D., Spain, D. A. 2020

    Abstract

    Pulmonary contusions are common injuries. Computed tomography reveals vast contused lung volume spectrum, yet pulmonary contusions are defined dichotomously (unilateral vs bilateral). We assessed whether there is stepwise increased risk of pulmonary complications among patients without, with unilateral, and with bilateral pulmonary contusion.We identified adults admitted with rib fractures using the largest US inpatient database. After propensity-score-matching patients without vs with unilateral vs bilateral pulmonary contusions and adjusting for residual confounders, we compared risk for pneumonia, ventilator-associated pneumonia (VAP), respiratory failure, intubation, and mortality.Among 148,140 encounters of adults with multiple rib fractures, 19% had concomitant pulmonary contusions. Matched patients with pulmonary contusions had increased risk of pneumonia 19% [95%CI:16-33%], respiratory failure 40% [95%CI: 31-50%], and intubation 46% [95%CI: 33-61%]. Delineation showed bilateral contusions, not unilateral contusions, attributed to increased risk of complications.There is likely a correlation between contused lung volume and risk of pulmonary complications; dichotomously classifying pulmonary contusions is insufficient. Better understanding this correlation requires establishing the clinically significant contusion volume and a correspondingly refined classification system.

    View details for DOI 10.1016/j.amjsurg.2020.07.022

    View details for PubMedID 32854902

  • Lessons from Epidemics, Pandemics, and Surgery. Journal of the American College of Surgeons Hakes, N. A., Choi, J. n., Spain, D. A., Forrester, J. D. 2020

    View details for DOI 10.1016/j.jamcollsurg.2020.08.736

    View details for PubMedID 32828842

  • The impact of trauma systems on patient outcomes Current Problems in Surgery Choi, J., Carlos, G., Nassar, A. K., Knowlton, L. M., Spain, D. A. 2020
  • Surgical Infection Society Guidelines for Antibiotic Use in Patients with Traumatic Facial Fractures. Surgical infections Forrester, J. D., Wolff, C. J., Choi, J. n., Colling, K. P., Huston, J. M. 2020

    Abstract

    Background: Facial fractures are common in traumatic injury. Antibiotic administration practices for traumatic facial fractures differ widely. Methods: The Surgical Infection Society's (SIS's) Therapeutics and Guidelines Committee convened to develop guidelines for antibiotic administration in the management of traumatic facial fractures. PubMed, Embase, and the Cochrane database were searched for pertinent studies. Pre-operative antibiotics were defined as those administered more than 1 hour before surgery. Peri-operative antibiotics were those administered within 1 hour of the start of surgery depending on the type of antibiotic and as late as ≤24 hours after surgery. Post-operative antibiotics were defined as those administered >24 hours after surgery. Prophylactic antibiotics were those administered for >24 hours without a documented infection. Evaluation of the published evidence was performed with the GRADE system. Using a process of iterative consensus, all committee members voted to accept or reject each recommendation. Results: We recommend that in adult patients with non-operative upper face, midface, or mandibular fractures, prophylactic antibiotics not be prescribed and that in adult patients with operative, non-mandibular fractures, pre-operative antibiotics likewise not be prescribed. We recommend that in adult patients with operative, mandibular fractures, pre-operative antibiotics not be prescribed; and in adult patients with operative, non-mandibular facial fractures, post-operative (>24 hours) antibiotics again not be prescribed. We recommend that in adult patients with operative, mandibular facial fractures, post-operative antibiotics (> 24 hours) not be prescribed. Conclusions: This guideline summarizes the current SIS recommendations regarding antibiotic management of patients with traumatic facial fractures.

    View details for DOI 10.1089/sur.2020.107

    View details for PubMedID 32598227

  • Necessity of routine chest radiograph in blunt trauma resuscitation: time to evaluate dogma with evidence. The journal of trauma and acute care surgery Choi, J. n., Forrester, J. D., Spain, D. A. 2020

    View details for DOI 10.1097/TA.0000000000002793

    View details for PubMedID 32467468

  • Evidenced-Based Practice Among Trainees: A Survey on Facial Trauma Wound Management. Journal of surgical education Choi, J. n., Traboulsi, A. A., Okland, T. S., Sadauskas, V. n., Perrault, D. n., Spain, D. A., Lorenz, H. P., Weiser, T. G. 2020

    Abstract

    Assess whether facial trauma wound care and antibiotic use recommendations are guided by evidence-based practice (EBP) or practice patterns, and investigate strategies to improve EBP adoption among surgical trainees.We conducted a survey of all trainees who manage facial trauma (general surgery, emergency medicine, plastic surgery, otolaryngology) to assess clinical knowledge and sources of treatment recommendations. Clinical questions were based on Oxford Center for Evidence-Based Medicine Level 1 or 2 evidence. We measured internal validity of questions using Cronbach's α. Results were weight-adjusted for nonresponse and then analyzed using Welch t test and descriptive statistics.Stanford Hospital and Clinics, a Level I trauma center.Response rate was 50.3% overall (78/155). For recommendations on facial trauma wound and antibiotic use, nonspecialty junior residents most frequently relied on their own senior or specialty residents (79.1%); nonspecialty senior residents relied on specialty residents (67.9%). Specialty junior residents most often relied on their own senior residents (51.0%), the majority of whom made recommendations based on their own knowledge (73.2%). Questions assessing EBP knowledge had Cronbach's α of 0.98; response accuracy was similar between specialty and nonspecialty residents (54.6% vs 55.5%, p = 0.96). When provided recommendations that conflict with EBP, both nonspecialty and specialty residents more frequently followed recommendations rather than EBP; junior residents reported doing so to avoid conflict with superiors. Total 92.6% of surveyed residents felt cross-departmental EBP guidelines would improve patient care.Facial trauma wound care and antibiotic recommendations disseminate down seniority and from craniofacial specialty to nonspecialty residents, yet knowledge of EBP among senior specialty and nonspecialty residents was weak. EBP may be difficult to adopt in the absence of consensus society guidelines. To address this gap, we published a review of EBP for facial trauma and plan to update our trauma manual with cross-departmental guidelines to facilitate EBP adoption among trainees.

    View details for DOI 10.1016/j.jsurg.2020.03.015

    View details for PubMedID 32461098

  • A Novel Approach to Deliver Therapeutic Extracellular Vesicles Directly into the Mouse Kidney Cells Ullah, M., Liu, D. D., Rai, S., Razavi, M., Choi, J., Wang, J., Concepcion, W., Thakor, A. S. 2020; 9 (4): 937

    View details for DOI 10.3390/cells9040937

  • Altered Mental Status and Hypercalcemia with a Splenic Mass. The journal of trauma and acute care surgery Khan, S., Choi, J., Patel, S. A., Spain, D. A. 2019

    View details for DOI 10.1097/TA.0000000000002534

    View details for PubMedID 31688787

  • LAPRA-TY for laparoscopic repair of traumatic diaphragmatic hernia without intracorporeal knot tying. Trauma surgery & acute care open Choi, J. n., Pan, J. n., Forrester, J. D., Spain, D. n., Browder, T. D. 2019; 4 (1): e000334

    Abstract

    A 38-year-old man was brought in by ambulance as a trauma activation after sustaining a self-inflicted stab wound in the left upper quadrant with a kitchen knife. His primary survey was unremarkable and his vital signs were normal. Secondary survey revealed a 2 cm transverse stab wound inferior and medial to the left nipple. Extended focused assessment with sonography for trauma (FAST) did not show intra-abdominal or pericardial fluid and chest X-ray did not show a definite pneumothorax or hemothorax.Wound exploration at bedside.Admit for observation and serial examinations.Exploratory laparotomy and open repair of traumatic diaphragmatic injury (TDI).Thoracotomy and open repair of TDI.Diagnostic laparoscopy and laparoscopic repair of TDI.

    View details for DOI 10.1136/tsaco-2019-000334

    View details for PubMedID 31321313

    View details for PubMedCentralID PMC6606065

  • Atraumatic acute forearm compartment syndrome due to systemic heparin. Trauma surgery & acute care open Chavez, G. n., Choi, J. n., Fogel, N. n., Jaramillo, J. D., Murphy, M. n., Spain, D. n. 2019; 4 (1): e000399

    View details for DOI 10.1136/tsaco-2019-000399

    View details for PubMedID 31799418

    View details for PubMedCentralID PMC6861105

  • Meckel's Diverticulum Fistulization: Another Complication to Consider. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Choi, J. n., Hawn, M. n. 2019

    View details for DOI 10.1007/s11605-019-04378-8

    View details for PubMedID 31468335

  • Perianal Extramammary Paget's Disease: More Than Meets the Eye. Digestive diseases and sciences Choi, J. n., Zemek, A. n., Lee, G. K., Kin, C. n. 2018

    View details for PubMedID 29696480

  • A Novel Approach for Therapeutic Delivery to the Rodent Pancreas Via Its Arterial Blood Supply. Pancreas Choi, J. n., Wang, J. n., Ren, G. n., Thakor, A. S. 2018; 47 (7): 910–15

    Abstract

    Endovascular techniques can now access the arterial blood supply of the pancreas in humans to enable therapeutics to reach the gland in high concentrations while concurrently avoiding issues related to non-targeted delivery. However, there is no way to replicate this in small animals. In a rat model, we therefore developed a novel non-terminal technique to deliver therapeutics to different regions of the pancreas, via its arterial blood supply.In female Wistar rats, selective branches of the celiac artery were temporarily ligated, depending on the region of the pancreas being targeted. Trypan blue dye was then administered as a surrogate marker for a therapeutic agent, via the celiac artery, and its staining/distribution throughout the pancreas determined. Postoperatively, animals were monitored daily, and serum was evaluated for markers of pancreatitis, liver, and metabolic function.Using this technique, we could selectively target the head, body/tail, or entire gland of the pancreas, via its arterial blood supply, with minimal nontarget staining. Following the procedure, all animals recovered with no evidence of pancreatitis or liver/metabolic dysfunction.Our study demonstrates a novel technique that can be used to selectively deliver therapeutics directly to the rat pancreas in a safe manner with full recovery of the animal.

    View details for PubMedID 29975350

  • Systems approach to uncover signaling networks in primary immunodeficiency diseases. journal of allergy and clinical immunology Choi, J., Fernandez, R., Maecker, H. T., Butte, M. J. 2017

    View details for DOI 10.1016/j.jaci.2017.03.025

    View details for PubMedID 28412396