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  • Attenuation of age-elevated blood factors by repositioning plasmapheresis: A novel perspective and approach. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis Mehdipour, M., Etienne, J., Liu, C., Mehdipour, T., Kato, C., Conboy, M., Conboy, I., Kiprov, D. D. 2021: 103162

    Abstract

    Aging is associated with the impairment of stem cell activation, leading to the functional decline of tissues and increasing the risk for age-associated diseases. The old, damaged or unrepaired tissues disturb distant tissue homeostasis by secreting factors into the circulation, which may not only serve as biomarkers for specific age-associated pathologies but also induce a variety of degenerative phenotypes. In this review, we summarize and discuss systemic determinants that perpetuate age-related tissue dysfunction. We further elaborate on the effects of attenuating these circulating factors by highlighting recent advances which utilize plasmapheresis in a pre-clinical or clinical setting. Overall, we postulate that repositioning therapeutic plasma exchange (TPE) to dilute the systemic factors, which become deleterious at their age-elevated levels, could be a rapidly effective rejuvenation therapy that recalibrates crucial signaling pathways to a youthful state.

    View details for DOI 10.1016/j.transci.2021.103162

    View details for PubMedID 34083162