Bio


Dr. Jing Tang is currently a postdoctoral fellow in Materials Science and Engineering under the advice of Professor Yi Cui, focused on rational design of bioinspired materials and devices for electrochemical interfaces and healthcare in Stanford University. Prior to joining Cui Group, she performed postdoctoral research jointly advised by Professors Daniel Kohane and Robert Langer from Harvard Medical School and MIT, and was working on remote controlled pain therapeutics from biomaterials to smart drug delivery systems. ​In her graduate thesis work, mentored by Professor Gengfeng Zheng, and in collaboration with Professor Jiayi Zhang, she explored the development of functional nanowire materials and devices, and carbon quantum dots​ synthesis, and the application of novel nanowire devices in cells, tissues and animals, especially for bioimaging, biosensing and restoration of sight in blind mice from Fudan University. She was a visiting graduate student in Chemical Engineering under the supervision of Professors Dongyuan Zhao and Wenlong Cheng including wearable sensor from Monash University, Melbourne, Australia.

Honors & Awards


  • Young Investigator Award in Northern California Chapter American Association of Physicists Symposium, AAPM Northern California Chapter (2019)
  • Winner of the 2018 NanoArt Image Contest, Lawrence Berkeley National Laboratory (2018)
  • Outstanding Poster Award of Vision Forum, Chinese Academy of Sciences (2017)
  • Outstanding Shanghai Graduate Students on Graduation, Shanghai (2016)
  • Singapore Challenge, Global Young Scientists Summit (GYSS) @one-north (Top 5), Singapore (2016)
  • Baosteel’s Principal Scholarship (Rank:1/479), BAOWU STEEL GROUP (2015)
  • Excellent Award of Nano Art Exhibition, Fudan University (2015)
  • Outstanding Teaching Assistant for General Chemistry (Brand Courses Taught in English for Overseas), China (2015)
  • Outstanding Teaching Award for the First National Brand Course Taught in English in China, Fudan University (2015)
  • Academic Star (Top 10), Fudan University (2014)
  • Elite Model Team (Top 10), Fudan University (2014)
  • Excellent Collective Model (Top 10), Fudan University (2014)
  • First Prize of Unilever-RSC Presentation Competition, Royal Society of Chemistry (2014)
  • Grand Prize Winner of Dow Sustainability Innovation Student Challenge Award, Dow Chemical Company (2014)
  • Kwang-Hua Scholarship, Kwang-Hua Education Foundation (2014)
  • National Scholarship for Graduate Students, Ministry of Education (2014)
  • Representative of Universitas 21 (U21) Graduate Research Conference in New Zealand (Top 4), Universitas 21 (2014)
  • Distinguished Award of BASF Scholarship, BASF Corporation (2013)
  • Excellent Award of Nano Art Exhibition, Fudan University (2013)
  • Luk Chung Lam Scholarship, Luk Chung Lam Education Foundation (2013)
  • Outstanding Student (Top 10), Fudan University (2013)
  • The Interdisciplinary Outstanding Doctoral Research Grant for Three Years, Fudan University (2013)
  • Outstanding Poster Award of Doctoral Forum, Fudan University (2012)
  • Kwang-Hua Scholarship, Kwang-Hua Education Foundation (2011)
  • Excellent Shanghai World Expo Volunteer Team, Expo 2010 Shanghai (2010)
  • Outstanding Shanghai Municipal Government World Expo Command Volunteer Individual, Shanghai Municipal Government (2010)
  • First-Class Academic Scholarship, Tongji University (2009-2011)

Boards, Advisory Committees, Professional Organizations


  • Seminar Committee, Stanford Neurosciences Institute (2019 - Present)
  • Member, ACS National Meeting (2018 - Present)
  • Session Chair, Materials Research Society Fall Meeting (2018 - 2018)
  • Member, Society for Biomaterials (2016 - Present)
  • Member, Biomedical Engineering Society (2016 - Present)
  • Co-Founder and Organizer, Boston Health Sciences and Technology (2016 - 2017)
  • Member, Materials Research Society (2014 - Present)
  • Chair, Dow Sustainability Innovation Student Team (2014 - 2014)
  • Chair of the Academics, Research and Careers Committee, Fudan Advanced Materials Laboratory Students Council (2012 - 2015)
  • Co-President, The Royal Society of Chemistry-Fudan University Students Association (2012 - 2015)
  • President, Fudan Advanced Materials Laboratory Students Association (2012 - 2015)
  • Chair, Shanghai Municipal Government World Expo Command Volunteer Team (2011 - 2011)

Professional Education


  • PhD, Fudan University (Graduated with Highest Honors), Laboratory of Advanced Materials and Department of Chemistry (2016)

Stanford Advisors


  • Yi Cui, Postdoctoral Faculty Sponsor

Research Interests


  • Achievement
  • Brain and Learning Sciences
  • Collaborative Learning
  • Curriculum and Instruction
  • Diversity and Identity
  • Leadership and Organization
  • Professional Development
  • Research Methods
  • Science Education
  • Teachers and Teaching
  • Technology and Education

Current Research and Scholarly Interests


​Research Interests (Transform Engineering, the Environment and Medicine by Creating New Materials and Devices using Nature’s Design Principles)
Bioinspired Materials and Devices, Electrochemical Interfaces, Brain Machine Interface, Biosensor, Biomaterials and Drug Delivery, Soft Materials, Neuroscience, Biomedical Engineering, Single Atom Catalysts, Biocatalysis, Sustainability

Lab Affiliations


All Publications


  • Surface-engineered mesoporous silicon microparticles as high-Coulombic-efficiency anodes for lithium-ion batteries NANO ENERGY Wang, J., Liao, L., Lee, H., Shi, F., Huang, W., Zhao, J., Pei, A., Tang, J., Zheng, X., Chen, W., Cui, Y. 2019; 61: 404–10
  • Direct/Alternating Current Electrochemical Method for Removing and Recovering Heavy Metal from Water Using Graphene Oxide Electrode. ACS nano Liu, C., Wu, T., Hsu, P., Xie, J., Zhao, J., Liu, K., Sun, J., Xu, J., Tang, J., Ye, Z., Lin, D., Cui, Y. 2019

    Abstract

    Treatment of heavy-metal pollution in both point-of-use water and industrial wastewater is critical in protecting human health and the environment. Current methods for heavy-metal treatment in both sources have limitations. For point-of-use water, current methods usually suffer from limited capacity and difficulties in spontaneously removing multiple heavy metals. For industrial wastewater, current methods greatly reduce the value of heavy metal by precipitating them as sludge which requires further treatment. Here we developed an electrochemical method that can treat both low-concentration and high-concentration heavy-metal pollution using either direct current (DC) or alternating current (AC) electrodeposition with graphene-oxide-modified carbon felt electrode (CF-GO). The graphene oxide provides a high density of surface functional groups to assist the electrodeposition. The electrodeposition method showed 2 orders of magnitude higher capacity (>29 g heavy metal for 1 g of graphene oxide) compared with traditional adsorption methods. For low levels of heavy-metal pollution in point-of-use water, DC electrodeposition with a CF-GO electrode can reduce single heavy-metal ion pollution (Cu, Cd, and Pb) as well as multiple ion mixtures to below safe water drinking levels. This method can tolerate a much wider range of heavy-metal pollution in point-of-use water than traditional adsorption methods. For high-level pollution in industrial wastewater, AC electrodeposition can recover >99.9% heavy-metal ions. By tuning the AC frequency and voltage, the electrodeposition method can further selectively recover Cu, Cd, and Pb separately, which adds values to the heavy-metal removal process.

    View details for DOI 10.1021/acsnano.8b09301

    View details for PubMedID 31117369

  • One-dimensional CoS2-MoS2 nano-flakes decorated MoO2 sub-micro-wires for synergistically enhanced hydrogen evolution. Nanoscale Wang, Y., Zhu, Y., Afshar, S., Woo, M. W., Tang, J., Williams, T., Kong, B., Zhao, D., Wang, H., Selomulya, C. 2019

    Abstract

    CoS2-MoS2 nanoflakes decorated MoO2 (CoMoOS) hybrid submicro-wires with rich active interfaces were synthesized via the sulfuration of CoMoO4. They showed excellent activity while synergistically catalyzing the hydrogen evolultion reaction (HER) in basic media by promoting both the water dissociation and hydrogen absorption steps. Thus, the CoMoOS catalysts only needed 123 mV to achieve 10 mA cm-2 with a small Tafel slope in alkaline solutions, and required 1.68 V to obtain the same current density when assembled into an alkaline electrolyser.

    View details for DOI 10.1039/c8nr08418a

    View details for PubMedID 30741297

  • Theory-guided Sn/Cu alloying for efficient CO2 electroreduction at low overpotentials NATURE CATALYSIS Zheng, X., Ji, Y., Tang, J., Wang, J., Liu, B., Steinruck, H., Lim, K., Li, Y., Toney, M. F., Chan, K., Cui, Y. 2019; 2 (1): 55–61
  • Remediation of heavy metal contaminated soil by asymmetrical alternating current electrochemistry. Nature communications Xu, J., Liu, C., Hsu, P. C., Zhao, J., Wu, T., Tang, J., Liu, K., Cui, Y. 2019; 10 (1): 2440

    Abstract

    Soil contamination by heavy metals constitutes an important environmental problem, whereas field applicability of existing remediation technologies has encountered numerous obstacles, such as long operation time, high chemical cost, large energy consumption, secondary pollution, and soil degradation. Here we report the design and demonstration of a remediation method based on a concept of asymmetrical alternating current electrochemistry that achieves high degrees of contaminant removal for different heavy metals (copper, lead, cadmium) at different initial concentrations (from 100 to 10,000 ppm), all reaching corresponding regulation levels for residential scenario after rational treatment time (from 30 min to 6 h). No excessive nutrient loss in treated soil is observed and no secondary toxic product is produced. Long-term experiment and plant assay show the high sustainability of the method and its feasibility for agricultural use.

    View details for DOI 10.1038/s41467-019-10472-x

    View details for PubMedID 31164649

  • Nanowire arrays restore vision in blind mice NATURE COMMUNICATIONS Tang, J., Qin, N., Chong, Y., Diao, Y., Yiliguma, Wang, Z., Xue, T., Jiang, M., Zhang, J., Zheng, G. 2018; 9: 786

    Abstract

    The restoration of light response with complex spatiotemporal features in retinal degenerative diseases towards retinal prosthesis has proven to be a considerable challenge over the past decades. Herein, inspired by the structure and function of photoreceptors in retinas, we develop artificial photoreceptors based on gold nanoparticle-decorated titania nanowire arrays, for restoration of visual responses in the blind mice with degenerated photoreceptors. Green, blue and near UV light responses in the retinal ganglion cells (RGCs) are restored with a spatial resolution better than 100 µm. ON responses in RGCs are blocked by glutamatergic antagonists, suggesting functional preservation of the remaining retinal circuits. Moreover, neurons in the primary visual cortex respond to light after subretinal implant of nanowire arrays. Improvement in pupillary light reflex suggests the behavioral recovery of light sensitivity. Our study will shed light on the development of a new generation of optoelectronic toolkits for subretinal prosthetic devices.

    View details for DOI 10.1038/s41467-018-03212-0

    View details for Web of Science ID 000426657700002

    View details for PubMedID 29511183

    View details for PubMedCentralID PMC5840349

  • Nuclear-Targeted Multifunctional Magnetic Nanoparticles for Photothermal Therapy ADVANCED HEALTHCARE MATERIALS Peng, H., Tang, J., Zheng, R., Guo, G., Dong, A., Wang, Y., Yang, W. 2017; 6 (7)

    Abstract

    The pursuit of multifunctional, innovative, more efficient, and safer cancer treatment has gained increasing interest in the research of preclinical nanoparticle-mediated photothermal therapy (PTT). Cell nucleus is recognized as the ideal target for cancer treatment because it plays a central role in genetic information and the transcription machinery reside. In this work, an efficient nuclear-targeted PTT strategy is proposed using transferrin and TAT peptide (TAT: YGRKKRRQRRR) conjugated monodisperse magnetic nanoparticles, which can be readily functionalized and stabilized for potential diagnostic and therapeutic applications. The monodisperse magnetic nanoparticles exhibit high photothermal conversion efficiency (≈37%) and considerable photothermal stability. They also show a high magnetization value and transverse relaxivity (207.1 mm-1 s-1 ), which could be applied for magnetic resonance imaging. The monodisperse magnetic nanoparticles conjugated with TAT peptides can efficiently target the nucleus and achieve the imaging-guided function, efficient cancer cells killing ability. Therefore, this work may present a practicable strategy to develop subcellular organelle targeted PTT agents for simultaneous cancer targeting, imaging, and therapy.

    View details for DOI 10.1002/adhm.201601289

    View details for Web of Science ID 000399719900010

    View details for PubMedID 28128891

  • Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart THERANOSTICS Wang, W., Tao, H., Zhao, Y., Sun, X., Tang, J., Selomulya, C., Tang, J., Chen, T., Wang, Y., Shu, M., Wei, L., Yi, G., Zhou, J., Wei, L., Wang, C., Kong, B. 2017; 7 (7): 1966–75

    Abstract

    The construction, characterization and surgical application of a multilayered iron oxide-based macroporous composite framework were reported in this study. The framework consisted of a highly porous iron oxide core, a gelatin-based hydrogel intermediary layer and a matrigel outer cover, which conferred a multitude of desirable properties including excellent biocompatibility, improved mechanical strength and controlled biodegradability. The large pore sizes and high extent of pore interconnectivity of the framework stimulated robust neovascularization and resulted in substantially better cell viability and proliferation as a result of improved transport efficiency for oxygen and nutrients. In addition, rat models with myocardial infraction showed sustained heart tissue regeneration over the infract region and significant improvement of cardiac functions following the surgical implantation of the framework. These results demonstrated that the current framework might hold great potential for cardiac repair in patients with myocardial infraction.

    View details for DOI 10.7150/thno.16866

    View details for Web of Science ID 000402093200016

    View details for PubMedID 28638482

    View details for PubMedCentralID PMC5479283

  • Direct Superassemblies of Freestanding Metal-Carbon Frameworks Featuring Reversible Crystalline-Phase Transformation for Electrochemical Sodium Storage JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Kong, B., Zu, L., Peng, C., Zhang, Y., Zhang, W., Tang, J., Selomulya, C., Zhang, L., Chen, H., Wang, Y., Liu, Y., He, H., Wei, J., Ling, X., Luo, W., Yang, J., Zhao, Z., Liu, Y., Yang, J., Zhao, D. 2016; 138 (50): 16533–41

    Abstract

    High-power sodium-ion batteries (SIBs) with long-term cycling attract increasing attention for large-scale energy storage. However, traditional SIBs toward practical applications still suffer from low rate capability and poor cycle induced by pulverization and amorphorization of anodes at high rate (over 5 C) during the fast ion insertion/extraction process. The present work demonstrates a robust strategy for a variety of (Sb-C, Bi-C, Sn-C, Ge-C, Sb-Bi-C) freestanding metal-carbon framework thin films via a space-confined superassembly (SCSA) strategy. The sodium-ion battery employing the Sb-C framework exhibits an unprecedented performance with a high specific capacity of 246 mAh g-1, long life cycle (5000 cycles), and superb capacity retention (almost 100%) at a high rate of 7.5 C (3.51A g-1). Further investigation indicates that the unique framework structure enables unusual reversible crystalline-phase transformation, guaranteeing the fast and long-cyclability sodium storage. This study may open an avenue to developing long-cycle-life and high-power SIBs for practical energy applications.

    View details for DOI 10.1021/jacs.6b10782

    View details for Web of Science ID 000390729500051

    View details for PubMedID 27936645

  • Photoelectrochemical Conversion from Graphitic C3N4 Quantum Dot Decorated Semiconductor Nanowires ACS APPLIED MATERIALS & INTERFACES An, T., Tang, J., Zhang, Y., Quan, Y., Gong, X., Al-Enizi, A. M., Elzatahry, A. A., Zhang, L., Zheng, G. 2016; 8 (20): 12772–79

    Abstract

    Despite the recent progress of developing graphitic carbon nitride (g-C3N4) as a metal-free photocatalyst, the synthesis of nanostructured g-C3N4 has still remained a complicated and time-consuming approach from its bulk powder, which substantially limits its photoelectrochemical (PEC) applications as well as the potential to form composites with other semiconductors. Different from the labor-intensive methods used before, such as exfoliation or assistant templates, herein, we developed a facile method to synthesize graphitic C3N4 quantum dots (g-CNQDs) directly grown on TiO2 nanowire arrays via a one-step quasi-chemical vapor deposition (CVD) process in a homemade system. The as-synthesized g-CNQDs uniformly covered over the surface of TiO2 nanowires and exhibited attractive photoluminescence (PL) properties. In addition, compared to pristine TiO2, the heterojunction of g-CNQD-decorated TiO2 nanowires showed a substantially enhanced PEC photocurrent density of 3.40 mA/cm(2) at 0 V of applied potential vs Ag/AgCl under simulated solar light (300 mW/cm(2)) and excellent stability with ∼82% of the photocurrent retained after over 10 h of continuous testing, attributed to the quantum and sensitization effects of g-CNQDs. Density functional theory calculations were further carried out to illustrate the synergistic effect of TiO2 and g-CNQD. Our method suggests that a variety of g-CNQD-based composites with other semiconductor nanowires can be synthesized for energy applications.

    View details for DOI 10.1021/acsami.6b01534

    View details for Web of Science ID 000376825800026

    View details for PubMedID 27149607

  • Incorporation of well-dispersed sub-5-nm graphitic pencil nanodots into ordered mesoporous frameworks NATURE CHEMISTRY Kong, B., Tang, J., Zhang, Y., Jiang, T., Gong, X., Peng, C., Wei, J., Yang, J., Wang, Y., Wang, X., Zheng, G., Selomulya, C., Zhao, D. 2016; 8 (2): 171–78

    Abstract

    Over the past few decades the direct assembly of optical nanomaterials into ordered mesoporous frameworks has proved to be a considerable challenge. Here we propose the incorporation of ultrasmall (sub-5-nm) graphitic pencil nanodots into ordered mesoporous frameworks for the fabrication of optoelectronic materials. The nanodots, which were prepared from typical commercial graphite pencils by an electrochemical tailoring process, combine properties such as uniform size (∼3 nm), excellent dispersibility and high photoconversion efficiency (∼27%). These nanodots were incorporated into a variety of ordered mesoporous frameworks (TiO2, silica, carbon and silica-carbon materials) by co-assembly, driven by hydrogen bonding, with the frameworks' precursors. The resulting materials showed a high degree of ordering, and a sharp increase in their optical performance (for example, photocurrent density). We envisage that the large-scale synthesis of ultrasmall carbon nanodots and their incorporation into ordered mesoporous frameworks may facilitate the preparation of materials with a variety of optical properties.

    View details for DOI 10.1038/NCHEM.2405

    View details for Web of Science ID 000369327200016

    View details for PubMedID 26791901

  • Three-dimensional WS2 nanosheet networks for H2O2 produced for cell signaling NANOSCALE Tang, J., Quan, Y., Zhang, Y., Jiang, M., Al-Enizi, A. M., Kong, B., An, T., Wang, W., Xia, L., Gong, X., Zheng, G. 2016; 8 (10): 5786–92

    Abstract

    Hydrogen peroxide (H2O2) is an important molecular messenger for cellular signal transduction. The capability of direct probing of H2O2 in complex biological systems can offer potential for elucidating its manifold roles in living systems. Here we report the fabrication of three-dimensional (3D) WS2 nanosheet networks with flower-like morphologies on a variety of conducting substrates. The semiconducting WS2 nanosheets with largely exposed edge sites on flexible carbon fibers enable abundant catalytically active sites, excellent charge transfer, and high permeability to chemicals and biomaterials. Thus, the 3D WS2-based nano-bio-interface exhibits a wide detection range, high sensitivity and rapid response time for H2O2, and is capable of visualizing endogenous H2O2 produced in living RAW 264.7 macrophage cells and neurons. First-principles calculations further demonstrate that the enhanced sensitivity of probing H2O2 is attributed to the efficient and spontaneous H2O2 adsorption on WS2 nanosheet edge sites. The combined features of 3D WS2 nanosheet networks suggest attractive new opportunities for exploring the physiological roles of reactive oxygen species like H2O2 in living systems.

    View details for DOI 10.1039/c5nr09236a

    View details for Web of Science ID 000371665400048

    View details for PubMedID 26909564

  • Interlaced NiS2-MoS2 nanoflake-nanowires as efficient hydrogen evolution electrocatalysts in basic solutions JOURNAL OF MATERIALS CHEMISTRY A An, T., Wang, Y., Tang, J., Wei, W., Cui, X., Alenizi, A. M., Zhang, L., Zheng, G. 2016; 4 (35): 13439–43

    View details for DOI 10.1039/c6ta05022k

    View details for Web of Science ID 000382656500010

  • Plasmon-enhanced photoelectrochemical monitoring of Ca2+ from living cardiomyocytes JOURNAL OF ELECTROANALYTICAL CHEMISTRY Tang, J., Li, J., Sikdar, D., Kong, B., Quan, Y., Che, S., Wang, Y., Al-Enizi, A. M., Premaratne, M., Zheng, G. 2015; 759: 14–20
  • Nanoparticle Superlattices as Efficient Bifunctional Electrocatalysts for Water Splitting JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Li, J., Wang, Y., Zhou, T., Zhang, H., Sun, X., Tang, J., Zhang, L., Al-Enizi, A. M., Yang, Z., Zheng, G. 2015; 137 (45): 14305–12

    Abstract

    The solar-driven water splitting process is highly attractive for alternative energy utilization, while developing efficient, earth-abundant, bifunctional catalysts for both oxygen evolution reaction and hydrogen evolution reaction has remained as a major challenge. Herein, we develop an ordered CoMnO@CN superlattice structure as an efficient bifunctional water-splitting electrocatalyst, in which uniform Co-Mn oxide (CoMnO) nanoparticles are coated with a thin, continuous nitrogen-doped carbon (CN) framework. The CoMnO nanoparticles enable optimized OER activity with effective electronic structure configuration, and the CN framework serves as an excellent HER catalyst. Importantly, the ordered superlattice structure is beneficial for enhanced reactive sites, efficient charge transfer, and structural stability. This bifunctional superlattice catalyst manifests optimized current densities and electrochemical stability in overall water splitting, outperforming most of the previously reported single- or bifunctional electrocatalysts. Combining with a silicon photovoltaic cell, this CoMnO@CN superlattice bifunctional catalyst enables unassisted solar water splitting continuously for ∼5 days with a solar-to-hydrogen conversion efficiency of ∼8.0%. Our discovery suggests that these transition metal oxide-based superlattices may serve as a unique structure modality for efficient bifunctional water splitting electrocatalysts with scale-up potentials.

    View details for DOI 10.1021/jacs.5b07756

    View details for Web of Science ID 000365148500016

    View details for PubMedID 26496655

  • Solar-Energy-Driven Photoelectrochemical Biosensing Using TiO2 Nanowires CHEMISTRY-A EUROPEAN JOURNAL Tang, J., Li, J., Da, P., Wang, Y., Zheng, G. 2015; 21 (32): 11288–99

    Abstract

    Photoelectrochemical sensing represents a unique means for chemical and biological detection, with foci of optimizing semiconductor composition and electronic structures, surface functionalization layers, and chemical detection methods. Here, we have briefly discussed our recent developments of TiO2 nanowire-based photoelectrochemical sensing, with particular emphasis on three main detection mechanisms and corresponding examples. We have also demonstrated the use of the photoelectrochemical sensing of real-time molecular reaction kinetic measurements, as well as direct interfacing of living cells and probing of cellular functions.

    View details for DOI 10.1002/chem.201406643

    View details for Web of Science ID 000358514400004

    View details for PubMedID 25962650

  • Growth of Single-Layered Two-Dimensional Mesoporous Polymer/Carbon Films by Self-Assembly of Monomicelles at the Interfaces of Various Substrates ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Fang, Y., Lv, Y., Tang, J., Wu, H., Jia, D., Feng, D., Kong, B., Wang, Y., Elzatahry, A. A., Al-Dahyan, D., Zhang, Q., Zheng, G., Zhao, D. 2015; 54 (29): 8425–29

    Abstract

    Single-layered two-dimensional (2D) ultrathin mesoporous polymer/carbon films are grown by self-assembly of monomicelles at the interfaces of various substrates, which is a general and common modification strategy. These unconventional 2D mesoporous films possess only a single layer of mesopores, while the size of the thin films can grow up to inch size in the plane. Free-standing transparent mesoporous carbon ultrathin films, together with the ordered mesoporous structure on the substrates of different compositions (e.g. metal oxides, carbon) and morphologies (e.g. nanocubes, nanodiscs, flexible and patterned substrates) have been obtained. This strategy not only affords controllable hierarchical porous nanostructures, but also appends the easily modified and multifunctional properties of carbon to the primary substrate. By using this method, we have fabricated Fe2 O3 -mesoporous carbon photoelectrochemical biosensors, which show excellent sensitivity and selectivity for glutathione.

    View details for DOI 10.1002/anie.201502845

    View details for Web of Science ID 000358050300018

    View details for PubMedID 26088947

  • Mesoporous Fe2O3-CdS Heterostructures for Real-Time Photoelectrochemical Dynamic Probing of Cu2+ ANALYTICAL CHEMISTRY Tang, J., Li, J., Zhang, Y., Kong, B., Yiliguma, Wang, Y., Quan, Y., Cheng, H., Al-Enizi, A. M., Gong, X., Zheng, G. 2015; 87 (13): 6703–8

    Abstract

    A three-dimensional (3D) mesoporous Fe2O3-CdS nanopyramid heterostructure is developed for solar-driven, real-time, and selective photoelectrochemical sensing of Cu(2+) in the living cells. Fabrication of the mesoporous Fe2O3 nanopyramids is realized by an interfacial aligned growth and self-assembly process, based on the van der drift model and subsequent selective in situ growth of CdS nanocrystals. The as-prepared mesoporous Fe2O3-CdS heterostructures achieve significant enhancement (∼3-fold) in the photocurrent density compared to pristine mesoporous Fe2O3, which is attributed to the unique mesoporous heterostructures with multiple features including excellent flexibility, high surface area (∼87 m(2)/g), and large pore size (∼20 nm), enabling the PEC performance enhancement by facilitating ion transport and providing more active electrochemical reaction sites. In addition, the introduction of Cu(2+) enables the activation of quenching the charge transfer efficiency, thus leading to sensitive photoelectrochemical recording of Cu(2+) level in buffer and cellular environments. Furthermore, real-time monitoring (∼0.5 nM) of Cu(2+) released from apoptotic HeLa cell is performed using the as-prepared 3D mesoporous Fe2O3-CdS sensor, suggesting the capability of studying the nanomaterial-cell interfaces and illuminating the role of Cu(2+) as trace element.

    View details for DOI 10.1021/acs.analchem.5b00844

    View details for Web of Science ID 000357839700043

    View details for PubMedID 26069939

  • Interfacial assembly of mesoporous nanopyramids as ultrasensitive cellular interfaces featuring efficient direct electrochemistry NPG ASIA MATERIALS Kong, B., Sikdar, D., Tang, J., Liu, Y., Premaratne, M., Zhang, W., Jing, Y., Zheng, G., Selomulya, C., Zhao, D. 2015; 7

    View details for DOI 10.1038/am.2015.78

    View details for Web of Science ID 000209873700001

  • A flexible ligand-based wavy layered metal-organic framework for lithium-ion storage JOURNAL OF COLLOID AND INTERFACE SCIENCE An, T., Wang, Y., Tang, J., Wang, Y., Zhang, L., Zheng, G. 2015; 445: 320–25

    Abstract

    A substantial challenge for direct utilization of metal-organic frameworks (MOFs) as lithium-ion battery anodes is to maintain the rigid MOF structure during lithiation/delithiation cycles. In this work, we developed a flexible, wavy layered nickel-based MOF (C20H24Cl2N8Ni, designated as Ni-Me4bpz) by a solvothermal approach of 3,3',5,5'-tetramethyl-4,4'-bipyrazole (H2Me4bpz) with nickel(II) chloride hexahydrate. The obtained MOF materials (Ni-Me4bpz) with metal azolate coordination mode provide 2-dimensional layered structure for Li(+) intercalation/extraction, and the H2Me4bpz ligands allow for flexible rotation feature and structural stability. Lithium-ion battery anodes made of the Ni-Me4bpz material demonstrate excellent specific capacity and cycling performance, and the crystal structure is well preserved after the electrochemical tests, suggesting the potential of developing flexible layered MOFs for efficient and stable electrochemical storage.

    View details for DOI 10.1016/j.jcis.2015.01.012

    View details for Web of Science ID 000350006700038

    View details for PubMedID 25638743

  • Branched Artificial Nanofinger Arrays by Mesoporous Interfacial Atomic Rearrangement JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Kong, B., Tang, J., Zhang, Y., Selomulya, C., Gong, X., Liu, Y., Zhang, W., Yang, J., Wang, W., Sun, X., Wang, Y., Zheng, G., Zhao, D. 2015; 137 (12): 4260–66

    Abstract

    The direct production of branched semiconductor arrays with highly ordered orientation has proven to be a considerable challenge over the last two decades. Here we report a mesoporous interfacial atomic rearrangement (MIAR) method to directly produce highly crystalline, finger-like branched iron oxide nanoarrays from the mesoporous nanopyramids. This method has excellent versatility and flexibility for heteroatom doping of metallic elements, including Sn, Bi, Mn, Fe, Co, Ni, Cu, Zn, and W, in which the mesoporous nanopyramids first absorb guest-doping molecules into the mesoporous channels and then convert the mesoporous pyramids into branching artificial nanofingers. The crystalline structure can provide more optoelectronic active sites of the nanofingers by interfacial atomic rearrangements of doping molecules and mesopore channels at the porous solid-solid interface. As a proof-of-concept, the Sn-doped Fe2O3 artificial nanofingers (ANFs) exhibit a high photocurrent density of ∼1.26 mA/cm(2), ∼5.25-fold of the pristine mesoporous Fe2O3 nanopyramid arrays. Furthermore, with surface chemical functionalization, the Sn-doped ANF biointerfaces allow nanomolar level recognition of metabolism-related biomolecules (∼5 nm for glutathione). This MIAR method suggests a new growth means of branched mesostructures, with enhanced optoelectronic applications.

    View details for DOI 10.1021/jacs.5b01747

    View details for Web of Science ID 000352244800043

    View details for PubMedID 25764364

  • Freestanding 3D graphene/cobalt sulfide composites for supercapacitors and hydrogen evolution reaction RSC ADVANCES Wang, Y., Tang, J., Kong, B., Jia, D., Wang, Y., An, T., Zhang, L., Zheng, G. 2015; 5 (9): 6886–91

    View details for DOI 10.1039/c4ra15912h

    View details for Web of Science ID 000347410600084

  • Sub-5 nm porous nanocrystals: interfacial site-directed growth on graphene for efficient biocatalysis CHEMICAL SCIENCE Kong, B., Sun, X., Selomulya, C., Tang, J., Zheng, G., Wang, Y., Zhao, D. 2015; 6 (7): 4029–34

    Abstract

    The direct production of macromolecular scale (sub-5 nm) porous nanocrystals with high surface area has been a considerable challenge over the past two decades. Here we report an interfacial site-directed capping agent-free growth method to directly produce porous ultrasmall (sub-5 nm), fully crystalline, macromolecular scale nanocrystals. The porous sub-5 nm Prussian blue nanocrystals exhibit uniform sizes (∼4 ± 1 nm), high surface area (∼855 m2 g-1), fast electron transfer (rate constant of ∼9.73 s-1), and outstanding sustained catalytic activity (more than 450 days). The nanocrystal-based biointerfaces enable unprecedented sub-nanomolar level recognition of hydrogen peroxide (∼0.5 nM limit of detection). This method also paves the way towards the creation of ultrasmall porous nanocrystals for efficient biocatalysis.

    View details for DOI 10.1039/c5sc00819k

    View details for Web of Science ID 000356176200044

    View details for PubMedID 28717465

    View details for PubMedCentralID PMC5497271

  • Direct growth of mesoporous carbon-coated Ni nanoparticles on carbon fibers for flexible supercapacitors JOURNAL OF MATERIALS CHEMISTRY A Li, J., Wang, Y., Tang, J., Wang, Y., Wang, T., Zhang, L., Zheng, G. 2015; 3 (6): 2876–82

    View details for DOI 10.1039/c4ta05668j

    View details for Web of Science ID 000348990500047

  • Reversible Chemical Tuning of Charge Carriers for Enhanced Photoelectrochemical Conversion and Probing of Living Cells SMALL Wang, Y., Tang, J., Zhou, T., Da, P., Li, J., Kong, B., Yang, Z., Zheng, G. 2014; 10 (23): 4967–74

    Abstract

    A facile, solution method for reversible tuning of oxygen vacancies inside TiO2 nanowires, in which the reducing treatment of TiO2 by NaBH4 leads to 2.4-fold increase of photocurrent density, compared to pristine TiO2 nanowires, is reported. Subsequent oxidizing treatment using KMnO4 or annealing in air can reset the photocurrent density to the original values. The incident photo-to-current conversion efficiency measurement exhibits that the reduced TiO2 nanowires present both enhanced photoactivity in both UV and visible regions. Density functional theory calculations reveal that the oxygen vacancies in the reduced TiO2 cause defect states in the band structure and result in enhanced carrier density and conductivity. In addition, the enhanced solar energy-driven photoelectrochemical conversion allows real-time, sensitive chemical probing of living cells that are directly grown on the TiO2 nanowire photoanodes. As proofs-of-concept, after functionalized with horseradish peroxidase (HRP) on the surface, the reduced TiO2 NWs demonstrate sensitive, real-time monitoring of the H2O2 levels in several distinctive living cell lines, with the lowest detectable H2O2 concentration of 7.7 nM. This reversible tuning of oxygen vacancies suggests a facile means for transition metal oxides, with enhanced photoconversion activity and electrochemical sensitivity.

    View details for DOI 10.1002/smll.201401059

    View details for Web of Science ID 000345973300020

    View details for PubMedID 25044916

  • Reduced Mesoporous Co3O4 Nanowires as Efficient Water Oxidation Electrocatalysts and Supercapacitor Electrodes ADVANCED ENERGY MATERIALS Wang, Y., Zhou, T., Jiang, K., Da, P., Peng, Z., Tang, J., Kong, B., Cai, W., Yang, Z., Zheng, G. 2014; 4 (16)
  • Bio-inspired porous antenna-like nanocube/nanowire heterostructure as ultra-sensitive cellular interfaces NPG ASIA MATERIALS Kong, B., Tang, J., Wu, Z., Selomulya, C., Wang, H., Wei, J., Wang, Y., Zheng, G., Zhao, D. 2014; 6

    View details for DOI 10.1038/am.2014.56

    View details for Web of Science ID 000341623700001

  • Surface Plasmon Resonance Enhanced Real-Time Photoelectrochemical Protein Sensing by Gold Nanoparticle-Decorated TiO2 Nanowires ANALYTICAL CHEMISTRY Da, P., Li, W., Lin, X., Wang, Y., Tang, J., Zheng, G. 2014; 86 (13): 6633–39

    Abstract

    Recently developed photoelectrochemical (PEC) sensing systems represent a unique potential detection method for real-time analysis of chemical/biological molecules, while the low absorption of TiO2 nanomaterials in the visible wavelength region and the slow surface charge transfer efficiency limit the ultimate sensitivity. Here we develop a gold nanoparticle-decorated TiO2 nanowire sensor for PEC detection of protein binding. The direct attachment of Au nanoparticles to TiO2 nanowires offers strong surface plasmon resonance for electrochemical field effect amplification, yielding a ~100% increase of photocurrent density. In addition, the surface functionalization of gold nanoparticles allows for direct capturing of target proteins near the Au/TiO2 interface and thus substantially enhances the capability of attenuation of energy coupling between Au and TiO2, leading to much-improved sensor performance. As a proof of concept, cholera toxin subunit B has been robustly detected by the TiO2-Au nanowire sensor functionalized with ganglioside GM1, with a high sensitivity of 0.167 nM and excellent selectivity. Furthermore, the real-time feature of photoelectrochemical sensing enables direct measurement of binding kinetics between cholera toxin subunit B and GM1, yielding association and disassociation rate constants and an equilibrium constant K(d) of 4.17 nM. This surface plasmon resonance-enhanced real-time, photoelectrochemical sensing design may lead to exciting biodetection capabilities with high sensitivity and real-time kinetic studies.

    View details for DOI 10.1021/ac501406x

    View details for Web of Science ID 000338488800064

    View details for PubMedID 24915128

  • Fully Solar-Powered Photoelectrochemical Conversion for Simultaneous Energy Storage and Chemical Sensing NANO LETTERS Wang, Y., Tang, J., Peng, Z., Wang, Y., Jia, D., Kong, B., Elzatahry, A. A., Zhao, D., Zheng, G. 2014; 14 (6): 3668–73

    Abstract

    We report the development of a multifunctional, solar-powered photoelectrochemical (PEC)-pseudocapacitive-sensing material system for simultaneous solar energy conversion, electrochemical energy storage, and chemical detection. The TiO2 nanowire/NiO nanoflakes and the Si nanowire/Pt nanoparticle composites are used as photoanodes and photocathodes, respectively. A stable open-circuit voltage of ∼0.45 V and a high pseudocapacitance of up to ∼455 F g(-1) are obtained, which also exhibit a repeating charging-discharging capability. The PEC-pseudocapacitive device is fully solar powered, without the need of any external power supply. Moreover, this TiO2 nanowire/NiO nanoflake composite photoanode exhibits excellent glucose sensitivity and selectivity. Under the sun light illumination, the PEC photocurrent shows a sensitive increase upon different glucose additions. Meanwhile in the dark, the open-circuit voltage of the charged pseudocapacitor also exhibits a corresponding signal over glucose analyte, thus serving as a full solar-powered energy conversion-storage-utilization system.

    View details for DOI 10.1021/nl5014579

    View details for Web of Science ID 000337337100107

    View details for PubMedID 24823370

  • Oriented Mesoporous Nanopyramids as Versatile Plasmon-Enhanced Interfaces JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Kong, B., Tang, J., Selomulya, C., Li, W., Wei, J., Fang, Y., Wang, Y., Zheng, G., Zhao, D. 2014; 136 (19): 6822–25

    Abstract

    We developed a facile interfacial oriented growth and self-assembly process to fabricate three-dimensional (3D) aligned mesoporous iron oxide nanopyramid arrays (NPAs). The unique NPAs possess a 3D mesostructure with multiple features, including high surface area (~175 m(2)/g), large pore size (~20 nm), excellent flexibility (bent over 150 times), and scalability at the foot scale for practical applications. More importantly, these NPAs structures enable versatile enhancement of localized surface plasmon resonance and photoelectrochemical conversion. The integration of plasmonic gold with 3D NPAs remarkably improves the performance of photoelectrochemical conversion, leading to ~6- and 83-fold increases of the photocurrent under simulated solar and visible-light illumination, respectively. The fabrication and investigation of NPAs provide a new paradigm for preparing unconventional mesoporous oriented thin films and further suggest a new strategy for designing plasmonic metal/semiconductor systems for effective solar energy harvesting.

    View details for DOI 10.1021/ja501517h

    View details for Web of Science ID 000336078400012

    View details for PubMedID 24786963

  • Solar-Driven Photoelectrochemical Probing of Nanodot/Nanowire/Cell Interface NANO LETTERS Tang, J., Zhang, Y., Kong, B., Wang, Y., Da, P., Li, J., Elzatahry, A. A., Zhao, D., Gong, X., Zheng, G. 2014; 14 (5): 2702–8

    Abstract

    We report a nitrogen-doped carbon nanodot (N-Cdot)/TiO2 nanowire photoanode for solar-driven, real-time, and sensitive photoelectrochemical probing of the cellular generation of H2S, an important endogenous gasotransmitter based on a tunable interfacial charge carrier transfer mechanism. Synthesized by a microwave-assisted solvothermal method and subsequent surface chemical conjugation, the obtained N-Cdot/TiO2 nanowire photoanode shows much enhanced photoelectrochemical photocurrent compared with pristine TiO2 nanowires. This photocurrent increase is attributed to the injection of photogenerated electrons from N-Cdots to TiO2 nanowires, confirmed by density functional theory simulation. In addition, the charge transfer efficiency is quenched by Cu(2+), whereas the introduction of H2S or S(2-) ions resets the charge transfer and subsequently the photocurrent, thus leading to sensitive photoelectrochemical recording of the H2S level in buffer and cellular environments. Moreover, this N-Cdot-TiO2 nanowire photoanode has been demonstrated for direct growth and interfacing of H9c2 cardiac myoblasts, with the capability of interrogating H2S cellular generation pathways by vascular endothelial growth factor stimulation as well as inhibition.

    View details for DOI 10.1021/nl500608w

    View details for Web of Science ID 000336074800072

    View details for PubMedID 24742186

  • Ultralight Mesoporous Magnetic Frameworks by Interfacial Assembly of Prussian Blue Nanocubes ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Kong, B., Tang, J., Wu, Z., Wei, J., Wu, H., Wang, Y., Zheng, G., Zhao, D. 2014; 53 (11): 2888–92

    Abstract

    A facile approach for the synthesis of ultralight iron oxide hierarchical structures with tailorable macro- and mesoporosity is reported. This method entails the growth of porous Prussian blue (PB) single crystals on the surface of a polyurethane sponge, followed by in situ thermal conversion of PB crystals into three-dimensional mesoporous iron oxide (3DMI) architectures. Compared to previously reported ultralight materials, the 3DMI architectures possess hierarchical macro- and mesoporous frameworks with multiple advantageous features, including high surface area (ca. 117 m(2) g(-1)) and ultralow density (6-11 mg cm(-3)). Furthermore, they can be synthesized on a kilogram scale. More importantly, these 3DMI structures exhibit superparamagnetism and tunable hydrophilicity/hydrophobicity, thus allowing for efficient multiphase interfacial adsorption and fast multiphase catalysis.

    View details for DOI 10.1002/anie.201308625

    View details for Web of Science ID 000336846300006

    View details for PubMedID 24519803

  • Aqueous Li-ion cells with superior cycling performance using multi-channeled polyaniline/Fe2O3 nanotube anodes JOURNAL OF MATERIALS CHEMISTRY A Wang, Y., Wang, Y., Tang, J., Xia, Y., Zheng, G. 2014; 2 (47): 20177–81

    View details for DOI 10.1039/c4ta04465g

    View details for Web of Science ID 000345066900031

  • Sensitive enzymatic glucose detection by TiO2 nanowire photoelectrochemical biosensors JOURNAL OF MATERIALS CHEMISTRY A Tang, J., Wang, Y., Li, J., Da, P., Geng, J., Zheng, G. 2014; 2 (17): 6153–57

    View details for DOI 10.1039/c3ta14173j

    View details for Web of Science ID 000333580700025

  • Mesoporous carbon coated molybdenum oxide nanobelts for improved lithium ion storage RSC ADVANCES Xu, M., Tang, J., Wu, H., Zheng, G. 2014; 4 (56): 29586–90

    View details for DOI 10.1039/c4ra04078c

    View details for Web of Science ID 000339669800027

  • Artificial metabolism-inspired photoelectrochemical probing of biomolecules and cells JOURNAL OF MATERIALS CHEMISTRY A Tang, J., Wang, Y., Wang, Y., Li, J., Kong, B., Jiang, M., Zheng, G. 2014; 2 (38): 15752–57

    View details for DOI 10.1039/c4ta03679d

    View details for Web of Science ID 000342079200010

  • CoNiO2/TiN-TiOxNy composites for ultrahigh electrochemical energy storage and simultaneous glucose sensing JOURNAL OF MATERIALS CHEMISTRY A Peng, Z., Jia, D., Tang, J., Wang, Y., Wang, Y., Zhang, L., Zheng, G. 2014; 2 (28): 10904–9

    View details for DOI 10.1039/c4ta00875h

    View details for Web of Science ID 000338435200020

  • Carbon Nanodots Featuring Efficient FRET for Real-Time Monitoring of Drug Delivery and Two-Photon Imaging ADVANCED MATERIALS Tang, J., Kong, B., Wu, H., Xu, M., Wang, Y., Wang, Y., Zhao, D., Zheng, G. 2013; 25 (45): 6569–74

    Abstract

    A FRET-based carbon nanodot (CDot) drug delivery platform has been developed. These CDots offer excellent biocompatibility, stable fluorescence, and efficient FRET between CDots and the attached fluorescent drug molecules, such as doxorubicin, enabling enhanced drug delivery, convenient cell imaging, and real-time monitoring of drug release. Moreover, the FRET-based two-photon imaging and drug tracking in deep tissues are also demonstrated.

    View details for DOI 10.1002/adma.201303124

    View details for Web of Science ID 000330106800010

    View details for PubMedID 23996326

  • Photoelectrochemical Detection of Glutathione by IrO2-Hemin-TiO2 Nanowire Arrays NANO LETTERS Tang, J., Kong, B., Wang, Y., Xu, M., Wang, Y., Wu, H., Zheng, G. 2013; 13 (11): 5350–54

    Abstract

    We have developed sensitive detection of glutathione using the IrO2-hemin-TiO2 nanowire arrays. Single-crystalline TiO2 nanowires are synthesized by a hydrothermal reaction, followed by surface functionalization of ~3 nm thick hemin and ~1-2 nm diameter IrO2 nanoparticles. The IrO2-hemin-TiO2 nanowire arrays offer much enhanced photocurrent with ∼100% increase compared to the pristine TiO2 nanowires and allow for label-free, real-time, sensitive photoelectrochemical detection of glutathione. The sensitivity achieved is ~10 nM in buffer, comparable to or better than most of the existing glutathione detection methods. Furthermore, cell extracts containing glutathione are robustly detected, with ~8000 cells/mL for HeLa cells and ~5000 cells/mL for human embryonic kidney 293T cells. This nanowire PEC sensor assay exhibits excellent selectivity and stability, suggesting a potential detection platform for analyzing the glutathione level in biosamples.

    View details for DOI 10.1021/nl4028507

    View details for Web of Science ID 000327111700055

    View details for PubMedID 24073599

  • Simultaneous Etching and Doping of TiO2 Nanowire Arrays for Enhanced Photoelectrochemical Performance ACS NANO Wang, Y., Zhang, Y., Tang, J., Wu, H., Xu, M., Peng, Z., Gong, X., Zheng, G. 2013; 7 (10): 9375–83

    Abstract

    We developed a postgrowth doping method of TiO2 nanowire arrays by a simultaneous hydrothermal etching and doping in a weakly alkaline condition. The obtained tungsten-doped TiO2 core-shell nanowires have an amorphous shell with a rough surface, in which W species are incorporated into the amorphous TiO2 shell during this simultaneous etching/regrowth step for the optimization of photoelectrochemical performance. Photoanodes made of these W-doped TiO2 core-shell nanowires show a much enhanced photocurrent density of ~1.53 mA/cm(2) at 0.23 V vs Ag/AgCl (1.23 V vs reversible hydrogen electrode), almost 225% of that of the pristine TiO2 nanowire photoanodes. The electrochemical impedance spectroscopy measurement and the density functional theory calculation demonstrate that the substantially improved performance of the dual W-doped and etched TiO2 nanowires is attributed to the enhancement of charge transfer and the increase of charge carrier density, resulting from the combination effect of etching and W-doping. This unconventional, simultaneous etching and doping of pregrown nanowires is facile and takes place under moderate conditions, and it may be extended for other dopants and host materials with increased photoelectrochemical performances.

    View details for DOI 10.1021/nn4040876

    View details for Web of Science ID 000326209100112

    View details for PubMedID 24047133

  • MnO Nanoparticle@Mesoporous Carbon Composites Grown on Conducting Substrates Featuring High-performance Lithium-ion Battery, Supercapacitor and Sensor SCIENTIFIC REPORTS Wang, T., Peng, Z., Wang, Y., Tang, J., Zheng, G. 2013; 3: 2693

    Abstract

    We demonstrate a facile, two-step coating/calcination approach to grow a uniform MnO nanoparticle@mesoporous carbon (MnO@C) composite on conducting substrates, by direct coating of the Mn-oleate precursor solution without any conducting/binding reagents, and subsequent thermal calcination. The monodispersed, sub-10 nm MnO nanoparticles offer high theoretical energy storage capacities and catalytic properties, and the mesoporous carbon coating allows for enhanced electrolyte transport and charge transfer towards/from MnO surface. In addition, the direct growth and attachment of the MnO@C nanocomposite in the supporting conductive substrates provide much reduced contact resistances and efficient charge transfer. These excellent features allow the use of MnO@C nanocomposites as lithium-ion battery and supercapacitor electrodes for energy storage, with high reversible capacity at large current densities, as well as excellent cycling and mechanical stabilities. Moreover, this MnO@C nanocomposite has also demonstrated a high sensitivity for H2O2 detection, and also exhibited attractive potential for the tumor cell analysis.

    View details for DOI 10.1038/srep02693

    View details for Web of Science ID 000324537600004

    View details for PubMedID 24045767

    View details for PubMedCentralID PMC3776197

  • Hollow-Core Magnetic Colloidal Nanocrystal Clusters with Ligand-Exchanged Surface Modification as Delivery Vehicles for Targeted and Stimuli-Responsive Drug Release CHEMISTRY-A EUROPEAN JOURNAL Li, D., Tang, J., Guo, J., Wang, S., Chaudhary, D., Wang, C. 2012; 18 (51): 16517–24

    Abstract

    The fabrication of hierarchical magnetic nanomaterials with well-defined structure, high magnetic response, excellent colloidal stability, and biocompatibility is highly sought after for drug-delivery systems. Herein, a new kind of hollow-core magnetic colloidal nanocrystal cluster (HMCNC) with porous shell and tunable hollow chamber is synthesized by a one-pot solvothermal process. Its novelty lies in the "tunability" of the hollow chamber and of the pore structure within the shell through controlled feeding of sodium citrate and water, respectively. Furthermore, by using the ligand-exchange method, folate-modified poly(acrylic acid) was immobilized on the surface of HMCNCs to create folate-targeted HMCNCs (folate-HMCNCs), which endowed them with excellent colloidal stability, pH sensitivity, and, more importantly, folate receptor-targeting ability. These assemblages exhibited excellent colloidal stability in plasma solution. Doxorubicin (DOX), as a model anticancer agent, was loaded within the hollow core of these folate-HMCNCs (folate-HMCNCs-DOX), and drug-release experiments proved that the folate-HMCNCs-DOX demonstrated pH-dependent release behavior. The folate-HMCNCs-DOX assemblages also exhibited higher potent cytotoxicity to HeLa cells than free doxorubicin. Moreover, folate-HMCNCs-DOX showed rapid cell uptake apart from the enhanced cytotoxicity to HeLa cells. Experimental results confirmed that the synthesized folate-HMCNCs are smart nanovehicles as a result of their improved folate receptor-targeting abilities and also because of their combined pH- and magnetic-stimuli response for applications in drug delivery.

    View details for DOI 10.1002/chem.201202249

    View details for Web of Science ID 000312275200031

    View details for PubMedID 23108596

  • Doxorubicin-Conjugated Mesoporous Magnetic Colloidal Nanocrystal Clusters Stabilized by Polysaccharide as a Smart Anticancer Drug Vehicle SMALL Li, D., Tang, J., Wei, C., Guo, J., Wang, S., Chaudhary, D., Wang, C. 2012; 8 (17): 2690–97

    Abstract

    Fabrication of magnetic nanocarriers that demonstrate enhanced biocompatibility and excellent colloidal stability is critical for the application of magnetic-motored drug delivery, and it remains a challenge. Herein, a novel approach to synthesize mesoporous magnetic colloidal nanocrystal clusters (MMCNCs) that are stabilized by agarose is described; these clusters demonstrate high magnetization, large surface area and pore volume, excellent colloidal stability, enhanced biocompatibility, and acid degradability. The hydroxyl groups of agarose, which cover the surface of the magnetic nanocrystals, are modified with vinyl groups, followed by click reaction with mercaptoacetyl hydrazine to form the terminal hydrazide (-CONHNH(2)). The anticancer agent doxorubicin (DOX) is then conjugated to MMCNCs through a hydrazone bond. The resulting hydrazone is acid cleavable, thereby providing a pH-sensitive drug release capability. This novel carrier provides an important step towards the construction of a new family of magnetic-motored drug-delivery systems. The experimental results show that the release rate of DOX from the DOX-conjugated MMCNCs (MMCNCs-DOX) is dramatically improved at low pH (tumor cell: pH 4-5 in the late stage of endolysosome and pH 5-6 from the early to late endosome), while almost no DOX is released at neutral pH (blood plasma). The cell cytotoxicity of the MMCNCs-DOX measured by MTT assay exhibits a comparable antitumor efficacy but lower cytotoxicity for normal cell lines, when measured against the free drug, thus achieving the aim of reducing side effects to normal tissues associated with controlled drug release.

    View details for DOI 10.1002/smll.201200272

    View details for Web of Science ID 000308303600012

    View details for PubMedID 22674615

  • One-Step Bulk Preparation of Calcium Carbonate Nanotubes and Its Application in Anticancer Drug Delivery BIOLOGICAL TRACE ELEMENT RESEARCH Tang, J., Sun, D., Qian, W., Zhu, R., Sun, X., Wang, W., Li, K., Wang, S. 2012; 147 (1-3): 408–17

    Abstract

    Bulk fabrication of ordered hollow structural particles (HSPs) with large surface area and high biocompatibility simultaneously is critical for the practical application of HSPs in biosensing and drug delivery. In this article, we describe a smart approach for batch synthesis of calcium carbonate nanotubes (CCNTs) based on supported liquid membrane (SLM) with large surface area, excellent structural stability, prominent biocompatibility, and acid degradability. The products were characterized by transmission electron micrograph, X-ray diffraction, Fourier transform infrared spectra, UV-vis spectroscopy, zeta potential, and particle size distribution. The results showed that the tube-like structure facilitated podophyllotoxin (PPT) diffusion into the cavity of hollow structure, and the drug loading and encapsulation efficiency of CCNTs for PPT are as high as 38.5 and 64.4 wt.%, respectively. In vitro drug release study showed that PPT was released from the CCNTs in a pH-controlled and time-dependent manner. The treatment of HEK 293T and SGC 7901 cells demonstrated that PPT-loaded CCNTs were less toxic to normal cells and more effective in antitumor potency compared with free drugs. In addition, PPT-loaded CCNTs also enhanced the apoptotic process on tumor cells compared with the free drugs. This study not only provides a new kind of biocompatible and pH-sensitive nanomaterial as the feasible drug container and carrier but more importantly establishes a facile approach to synthesize novel hollow structural particles on a large scale based on SLM technology.

    View details for DOI 10.1007/s12011-012-9325-9

    View details for Web of Science ID 000304610400058

    View details for PubMedID 22351100

  • Magnetic drug carrier with a smart pH-responsive polymer network shell for controlled delivery of doxorubicin JOURNAL OF MATERIALS CHEMISTRY Ma, W., Wu, K., Tang, J., Li, D., Wei, C., Guo, J., Wang, S., Wang, C. 2012; 22 (30): 15206–14

    View details for DOI 10.1039/c2jm31721d

    View details for Web of Science ID 000306215900057