- Lipidated cyclopropenes via a stable 3-N spirocyclopropene scaffold TETRAHEDRON LETTERS 2018; 59 (37): 3435–38
Visualizing the Brain's Astrocytes with Diverse Chemical Scaffolds
ACS CHEMICAL BIOLOGY
2018; 13 (6): 1493–98
Astrocytes are the most abundant cells in the brain. They support neurons, adjust synaptic strength, and modulate neuronal signaling, yet the full extent of their functions is obscured by the dearth of methods for their visualization and analysis. Here, we report a chemical reporter that targets small molecules specifically to astrocytes both in vitro and in vivo. Fluorescent versions of this tag are imported through an organic cation transporter to label glia across species. The structural modularity of this approach will enable wide-ranging applications for understanding astrocyte biology.
View details for DOI 10.1021/acschembio.8b00391
View details for Web of Science ID 000435746200011
View details for PubMedID 29733639