Honors & Awards
Postdoctoral Fellowship, Dr. Mildred-Scheel-Foundation, German Cancer Aid (01/2019-)
Residency, Goethe-University-Hospital Frankfurt, Internal Medicine and Hematology and Oncology (2015)
Doctor of Medicine, Albert Ludwigs Universitat Freiburg (2016)
Staatsexamen, Albert Ludwigs Universitat Freiburg (2014)
Visualization of activated T cells by OX40-immunoPET as a strategy for diagnosis of acute Graft-versus-Host-Disease.
Graft versus host disease (GvHD) is a major complication of allogeneic hematopoietic cell transplantation (HCT), mediated primarily by donor T cells that become activated and attack host tissues. Non-invasive strategies detecting T cell activation would allow for early diagnosis and possibly more effective management of HCT recipients. Positron emission tomography (PET) imaging is a sensitive and clinically relevant modality ideal for GvHD diagnosis and there is a strong rationale for the use of PET tracers that can monitor T cell activation and expansion with high specificity. The tumor necrosis factor (TNF) receptor superfamily member OX40 (CD134) is a cell surface marker that is highly specific for activated T cells, is upregulated during GvHD, and mediates disease pathogenesis. We recently reported the development of an antibody-based activated T cell imaging agent targeting OX40. In the present study, we visualize the dynamics of OX40 expression in a major histocompatibility complex (MHC)-mismatch mouse model of acute GvHD using OX40-immunoPET. This approach enabled visualization of T cell activation at early stages of disease, prior to overt clinical symptoms with high sensitivity and specificity. This study highlights the potential utility of the OX40 PET imaging as a new strategy for GvHD diagnosis and therapy monitoring.
View details for DOI 10.1158/0008-5472.CAN-20-1149
View details for PubMedID 32900772
Engineered IL-2 Cytokine-Cytokine Receptor Complex Enables Selective Expansion of Regulatory T Cells and Facilitates Establishment of Organ Transplantation Tolerance
ELSEVIER SCIENCE INC. 2020: S59–S60
View details for Web of Science ID 000516887900080