Dr. Lotfi enjoys working with a diverse patient population. He believes the cornerstone to lifelong health comes from a healthy diet, active exercise regimen, and consistent, quality sleep. He enjoys teaching the pathophysiology of disease to both medical students as well as patients. Outside of clinic you will likely find him on one of his road bikes.
- Internal Medicine
- Diagnostic Medicine
Clinical Assistant Professor, Medicine - Primary Care and Population Health
Associate Professor, Medicine - General Medicine (2016 - Present)
Honors & Awards
Process Improvement Finalist, Society of Hospital Medicine (2016)
Quality Improvement Finalist, American College of Physicians (2015)
Clinical Vignette Finalist, American College of Physicians (2013)
Helen McConnell Palthe Scholarship, University of California, Davis (2012)
Honor Society, Phi Kappa Phi (2012)
Honor Society, Alpha Omega Alpha (2011)
Residency:Stanford University Dept of Medicine (2016) CA
Medical Education:University of California Davis School of Medicine (2012) CA
MD, Stanford Hospital and Clinics, Internal Medicine Residency (2016)
Residency:Stanford University - Dept of PsychiatryCA
MD, University of California, Davis, Medical School (2012)
BS, University of California, Irvine, Biological Sciences (2005)
Community and International Work
Pacific Free Clinic; Arbor Clinic
Opportunities for Student Involvement
Current Research and Scholarly Interests
We enrolled four undergraduates into an independent study course and monitor how their outreach toward patients affects population health control.
Outpatient Curriculum Review, Stanford University (June 1, 2017 - Present)
Creating small group, case format for the internal medicine resident curriculum.
Consultative Medicine Director, Stanford Healthcare
Diagnosing complex disease
211 Quarry Road, Palo Alto
Wide-field functional imaging of blood flow and hemoglobin oxygen saturation in the rodent dorsal window chamber
2011; 82 (3): 199-209
The rodent dorsal window chamber is a widely used in vivo model of the microvasculature. The model consists of a 1cm region of exposed microvasculature in the rodent dorsal skin that is immobilized by surgically implanted titanium frames, allowing the skin microvasculature to be visualized. We describe a detailed protocol for surgical implantation of the dorsal window chamber which enables researchers to perform the window chamber implantation surgery. We further describe subsequent wide-field functional imaging of the chamber to obtain hemodynamic information in the form of blood oxygenation and blood flow on a cm size region of interest. Optical imaging techniques, such as intravital microscopy, have been applied extensively to the dorsal window chamber to study microvascular-related disease and conditions. Due to the limited field of view of intravital microscopy, detailed hemodynamic information typically is acquired from small regions of interest, typically on the order of hundreds of μm. The wide-field imaging techniques described herein complement intravital microscopy, allowing researchers to obtain hemodynamic information at both microscopic and macroscopic spatial scales. Compared with intravital microscopy, wide-field functional imaging requires simple instrumentation, is inexpensive, and can give detailed metabolic information over a wide field of view.
View details for DOI 10.1016/j.mvr.2011.07.004
View details for Web of Science ID 000297179700001
View details for PubMedID 21787792
Vascular Effects of Photodynamic and Pulsed Dye Laser Therapy Protocols
LASERS IN SURGERY AND MEDICINE
2008; 40 (9): 644-650
Pulsed dye laser (PDL) treatment of cutaneous vascular lesions is associated with variable and unpredictable efficacy. Thus, alternative treatment modalities are needed. Previous in vitro and in vivo studies have demonstrated enhanced selective vascular destruction with benzoporphyrin derivative (BPD) monoacid ring A photodynamic therapy (PDT) followed immediately by PDL irradiation (PDT+PDL). Here, we evaluate PDT alone, PDL alone, and PDT+PDL protocols using an optimized in vivo rodent dorsal window chamber model.A dorsal window chamber was surgically installed on male Golden Syrian hamsters. BPD solution was administered intravenously via a jugular venous catheter. Evaluated interventions included: (1) Control (no BPD, no light); (2) Control (BPD, no light); (3) PDT alone (lambda = 576 nm; 25, 50, 75, or 96 J/cm2 radiant exposure; 15 minutes post-BPD injection); (4) PDL alone at 7 J/cm2 (585 nm, 1.5 milliseconds pulse duration, 7 mm spot); and (5) PDT (25 or 75 J/cm2)+PDL (7 J/cm2). Laser speckle imaging was used to monitor blood flow dynamics before, immediately after, and 1, 3, and 5 days post-intervention.Perfusion reduction on day 1 post-intervention was achieved with PDT>50 J/cm2, PDL alone, and PDT+PDL. However, by day 5 post-intervention, recovery of flow was observed with PDT alone at 50 J/cm2 (-15.1%) and PDL alone (+215%). PDT (75 J/cm2)+PDL resulted in the greatest prolonged reduction in vascular perfusion (-99.8%).Our in vivo data suggest that the PDT+PDL therapeutic protocol can result in enhanced and persistent vascular shutdown compared to PDT or PDL alone. The PDT+PDL approach has potential for considerable superficial vascular destruction and should be considered as a treatment modality for cutaneous vascular lesions. Monitoring of blood flow changes for as long as possible is crucial for accurate assessment of light-based vascular interventions.
View details for DOI 10.1002/lsm.20673
View details for Web of Science ID 000260922200007
View details for PubMedID 18951421
- The importance of long-term monitoring to evaluate the microvascular response to light-based therapies. Journal of Investigative Dermatology 2008; 128 (2)
Treatment of cutaneous vascular lesions using multiple-intermittent cryogen spurts and two-wavelength laser pulses: Numerical and animal studies
LASERS IN SURGERY AND MEDICINE
2007; 39 (6): 494-503
Presently, cutaneous vascular lesions are treated using a single cryogen spurt and single laser pulse (SCS-SLP), which do not necessarily produce complete lesion removal in the majority of patients. In this study, the feasibility of applying multiple cryogen spurts intermittently with multiple two-wavelength laser pulses (MCS-MTWLP) was studied using numerical and animal models.Two treatment procedures were simulated: (1) SCS+532 nm SLP; and (2) MCS+532/1064 nm MTWLP. Light transport and heat diffusion in human skin were simulated with the Monte Carlo method and finite element model, respectively. Possible epidermal damage and blood vessel photocoagulation were evaluated with an Arrhenius-type kinetic model. Blood vessels in the rodent window chamber model (RWCM) were irradiated with either SLP or MTWLP. Laser-induced structural and functional changes in the vessels were documented by digital photography and laser speckle imaging (LSI).The numerical results show that the MCS-MTWLP approach can provide sufficient epidermal protection while simultaneously achieving photocoagulation of larger blood vessels as compared to SCS-SLP. Animal studies show that MTWLP has significant advantages over SLP by inducing irreversible damage to larger blood vessels without adverse effects.MCS-MTWLP may be a promising approach to improve therapeutic outcome for patients with cutaneous vascular lesions featuring large blood vessels.
View details for DOI 10.1002/lsm.20524
View details for Web of Science ID 000248601900003
View details for PubMedID 17659588