Throughout my scientific training, I have focused on building an interdisciplinary background in molecular parasitology, biochemistry, immunology, and public health to provide me with the skills needed to pursue development of a successful malaria vaccine. My PhD research at Harvard centered on understanding immune responses to the developing transmission stages of malaria. By providing the first evidence for natural immunity to immature transmission stages, this work supports interrupting development and maturation of these parasites as a novel approach to transmission-blocking vaccine design. During my postdoctoral fellowship and in the future, I hope to continue researching host-pathogen interactions with applications to malaria vaccine development, while also being involved in global health work in the field. Currently my work focuses on understanding mechanisms of natural immunity to malaria and immune tolerance, particularly in the context of gamma delta T cell and monocyte responses.
Honors & Awards
Edgar Haber Award, Harvard T.H. Chan School of Public Health (May 2017)
Harvard Global Health International Travel Fellowship, Harvard Global Health Institute (May 2012)
Herchel Smith Graduate Fellowship, Harvard University (April 2011)
Henry Hart Rice Foreign Residence Fellowship, Yale University (February 2010)
Bachelor of Science, Yale University (2010)
Doctor of Philosophy, Harvard University (2017)
Emerging role of gammadelta T cells in vaccine-mediated protection from infectious diseases.
Clinical & translational immunology
2019; 8 (8): e1072
gammadelta T cells are fascinating cells that bridge the innate and adaptive immune systems. They have long been known to proliferate rapidly following infection; however, the identity of the specific gammadelta T cell subsets proliferating and the role of this expansion in protection from disease have only been explored more recently. Several recent studies have investigated gammadelta T-cell responses to vaccines targeting infections such as Mycobacterium, Plasmodium and influenza, and studies in animal models have provided further insight into the association of these responses with improved clinical outcomes. In this review, we examine the evidence for a role for gammadelta T cells in vaccine-induced protection against various bacterial, protozoan and viral infections. We further discuss results suggesting potential mechanisms for protection, including cytokine-mediated direct and indirect killing of infected cells, and highlight remaining open questions in the field. Finally, building on current efforts to integrate strategies targeting gammadelta T cells into immunotherapies for cancer, we discuss potential approaches to improve vaccines for infectious diseases by inducing gammadelta T-cell activation and cytotoxicity.
View details for DOI 10.1002/cti2.1072
View details for PubMedID 31485329
- gamma delta T Cells in Antimalarial Immunity: New Insights Into Their Diverse Functions in Protection and Tolerance FRONTIERS IN IMMUNOLOGY 2018; 9
IMPACT OF RECURRENT MALARIA ON V Delta 2 Gamma Delta T CELL <it>IN VITRO</it> ANTI-PARASITIC ACTIVITY
AMER SOC TROP MED & HYGIENE. 2018: 112
View details for Web of Science ID 000461386602361
γδ T Cells in Antimalarial Immunity: New Insights Into Their Diverse Functions in Protection and Tolerance.
Frontiers in immunology
2018; 9: 2445
Uniquely expressing diverse innate-like and adaptive-like functions, γδ T cells exist as specialized subsets, but are also able to adapt in response to environmental cues. These cells have long been known to rapidly proliferate following primary malaria infection in humans and mice, but exciting new work is shedding light into their diverse functions in protection and following repeated malaria infection. In this review, we examine the current knowledge of functional specialization of γδ T cells in malaria, and the mechanisms dictating recognition of malaria parasites and resulting proliferation. We discuss γδ T cell plasticity, including changing interactions with other immune cells during recurrent infection and potential for immunological memory in response to repeated stimulation. Building on recent insights from human and murine experimental studies and vaccine trials, we propose areas for future research, as well as applications for therapeutic development.
View details for PubMedID 30405634
View details for PubMedCentralID PMC6206268