Education & Certifications
B.S., Yale University, Molecular Biophysics & Biochemistry (MB&B) and Linguistics (2013)
A mechanical perspective on phagocytic cup formation.
Current opinion in cell biology
2020; 66: 112–22
Phagocytosis is a widespread and evolutionarily conserved process with diverse biological functions, ranging from engulfment of invading microbes during infection to clearance of apoptotic debris in tissue homeostasis. Along with differences in biochemical composition, phagocytic targets greatly differ in physical attributes, such as size, shape, and rigidity, which are now recognized as important regulators of this process. Force exertion at the cell-target interface and cellular mechanical changes during phagocytosis are emerging as crucial factors underlying sensing of such target properties. With technological developments, mechanical aspects of phagocytosis are increasingly accessible experimentally, revealing remarkable organizational complexity of force exertion. An increasingly high-resolution picture is emerging of how target physical cues and cellular mechanical properties jointly govern important steps throughout phagocytic engulfment.
View details for DOI 10.1016/j.ceb.2020.05.011
View details for PubMedID 32698097
- Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens NATURE GENETICS 2018; 50 (12): 1716-+