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  • Work
    lucyrick@stanford.edu
    University - Staff Department: Medicine - Med/Cardiovascular Medicine Position: Research Assistant
    University - Affiliate Department: Medicine - Med/Cardiovascular Medicine

Additional Info

  • Mail Code: 5406

All Publications

  • Early, low-dose hydrocortisone and near-term brain connectivity in extremely preterm infants. Pediatric research Dubner, S. E., Rickerich, L., Bruckert, L., Poblaciones, R. V., Sproul, D., Scala, M., Feldman, H. M., Travis, K. E. 2023

    Abstract

    Postnatal steroids are used to prevent bronchopulmonary dysplasia in extremely preterm infants but may have adverse effects on brain development. We assessed connectivity metrics of major cerebral and cerebellar white matter pathways at near-term gestational age among infants who did or did not receive a standardized regimen of hydrocortisone during the first 10 days of life.Retrospective cohort study.Infants born <28 weeks: Protocol group (n = 33) received at least 50% and not more than 150% of an intended standard dose of 0.5 mg/kg hydrocortisone twice daily for 7 days, then 0.5 mg/kg per day for 3 days; Non-Protocol group (n = 22), did not receive protocol hydrocortisone or completed <50% of the protocol dose. We assessed group differences in near-term diffusion MRI mean fractional anisotropy (FA) and mean diffusivity (MD) across the corticospinal tract, inferior longitudinal fasciculus, corpus callosum and superior cerebellar peduncle.Groups were comparable in gestational age, post-menstrual age at scan, medical complications, bronchopulmonary dysplasia, and necrotizing enterocolitis. No significant large effect group differences were identified in mean FA or MD in any cerebral or cerebellar tract.Low dose, early, postnatal hydrocortisone was not associated with significant differences in white matter tract microstructure at near-term gestational age.This study compared brain microstructural connectivity as a primary outcome among extremely preterm infants who did or did not receive early postnatal hydrocortisone. Low dose hydrocortisone in the first 10 days of life was not associated with significant differences in white matter microstructure in major cerebral and cerebellar pathways. Hydrocortisone did not have a significant effect on early brain white matter circuits.

    View details for DOI 10.1038/s41390-023-02903-9

    View details for PubMedID 38030826

    View details for PubMedCentralID 3265791

  • Neonatal Inflammation, Corpus Callosum Microstructure, and Language Skills in 2-Year-Old Children Born Preterm Dubner, S. E., Sproul, D., Rickerich, L., Robles, I., Feldman, H., Travis, K. LIPPINCOTT WILLIAMS & WILKINS. 2022: E140-E141

    View details for Web of Science ID 000797424900075