Honors & Awards

  • Research journey interview featured by the journal Development, Development (2020)
  • Senior Research Fellow Award, Department of Biotechnology, India (2019-2020)
  • Best Oral Presentation Award, UNESCO-Regional Centre for Biotechnology Open day, Faridabad, India (2018)
  • Travel Award, Tsakura Science Club, Tsakura, Japan (2017)
  • Senior Research Fellow Award, Indian Council of Medical Research, India (2014-2019)
  • Junior Research Fellow Award, Indian Council of Agriculture Research, India (2013-2014)
  • National Eligibility Test Award, University Grant Commission, India (2013)
  • Best Poster Presentation Award, National Symposium on Emerging Trends in Biotechnology Research (2013)
  • Institutional fellowship, Indian Veterinary Research Institute, Izzatnagar, India (2011-2013)

Professional Education

  • Master of Science, Indian Veterinary Research Institute (2013)
  • Doctor of Veterinary Medicine, G B Pant University Of Agriculture (2011)
  • Doctor of Philosophy, Manipal Academy of Higher Education (2020)
  • PhD, UNESCO-Regional Centre for Biotechnology, Faridabad, India, Developmental Genetics (2020)
  • MVSc, Indian Veterinary Research Institute, Izzatnagar, India, Animal Biotechnology (2013)
  • BVSc & AH, Govind Ballabh Pant University of Agriculture and Technology, India, Veterinary Science (2011)

Stanford Advisors

Contact

  • Academic
    megha17@stanford.edu
    University - Scholar Department: Pediatrics Position: Postdoctoral Scholar

Additional Info

  • Mail Code: 5731

All Publications

  • TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation JOURNAL OF CELL SCIENCE Agarwal, M., Bharadwaj, A., Mathew, S. J. 2022; 135 (4)

    Abstract

    Muscle stem (satellite) cells express Pax7, a key transcription factor essential for satellite cell maintenance and adult muscle regeneration. We identify the corepressor transducin-like enhancer of split-4 (TLE4) as a Pax7 interaction partner expressed in quiescent satellite cells under homeostasis. A subset of satellite cells transiently downregulate TLE4 during early time points following muscle injury. We identify these to be activated satellite cells, and that TLE4 downregulation is required for Myf5 activation and myogenic commitment. Our results indicate that TLE4 represses Pax7-mediated Myf5 transcriptional activation by occupying the -111 kb Myf5 enhancer to maintain quiescence. Loss of TLE4 function causes Myf5 upregulation, an increase in satellite cell numbers and altered differentiation dynamics during regeneration. Thus, we have uncovered a novel mechanism to maintain satellite cell quiescence and regulate muscle differentiation mediated by the corepressor TLE4.

    View details for DOI 10.1242/jcs.256008

    View details for Web of Science ID 000762675900001

    View details for PubMedID 35099008