Master of Science in Engr, Technical University of Denmark (2005)
Doctor of Philosophy, Kjobenhavns Universitet (2011)
Jianghong Rao, Postdoctoral Faculty Sponsor
Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe.
Angewandte Chemie (International ed. in English)
2013; 52 (40): 10511-10514
Drug Design: An (18) F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the (18) F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation.
View details for DOI 10.1002/anie.201303422
View details for PubMedID 23881906