Honors & Awards


  • Research Award, Chiba University Graduate School of Medicine (2008)

Boards, Advisory Committees, Professional Organizations


  • Member, American Heart Association (2012 - Present)
  • Member, American College of Cardiology (2012 - Present)
  • Member, Japanese Society of Ultrasonic in Medicine (2010 - Present)
  • Member, Japanese College of Cardiology (2006 - Present)
  • Member, Japanese Society of Echocardiography (2005 - Present)
  • Member, Japanese Circulation Society (2003 - Present)
  • Member, Japan Society of Internal Medicine (2002 - Present)

Professional Education


  • Diplomate, Japanese Circulation Societ (2009)
  • Diplomate, Japanese Society of Internal Medicine (2006)
  • Doctor of Philosophy, Chiba University (2010)
  • Doctor of Medicine, Chiba University (2002)

Stanford Advisors


Current Research and Scholarly Interests


The human placentas are readily available and represent a rich source of novel extraembryonic mesodermal stem cell (hAMSCs) population from young healthy donors. The human amniotic mesenchymal stem cells (hAMSCs) are situated at the maternal-fetal border of the placenta and demonstrate unique characteristics, including partial pluripotency, cardiac progenitor phenotype, and immunoprivelege. These features enable universal cardiovascular cell therapy.

I would like to identify the optimal stem cell population for myocardial restoration.
Main focus of my research during my post-doctoral fellowship are
1) modify the immunomodulatory properties of stem cells
2) establish robust tissue engineering platform
3) assess stem cell engraftment/survival and myocardial function using BLI/cellular and molecular MRI

Journal Articles


  • Inducible intrapulmonary arteriovenous shunt in a patient with beriberi heart. Am J Respir Crit Care Med. Nakano, S., Sujino, Y., Tanno, J., Ayiyama, M., Muramats, T., Senbonmatsu, T., Nishimura, S., Tamura, Y., Fukuda, K. 2013; 187. (3): 332-3
  • Relationship of natriuretic peptide and transthoracic echocardiographic findings in 135 subjects with muscular dystrophy. Int J Cardiol Kawakubo, M., Funabashi, N., Komuro, I., et al 2010; 145 (3): 506-14
  • Doppler imaging predicts cardiac events in chronic pulmonary thromboembolism. Int J Cardiol Shiina, Y., Funabashi, N., Kawakubo, M., Komuro, I., et al 2009; 133 (2): 167-72
  • Right atrium contractility and right ventricular diastolic function assessed by pulsed tissue Doppler imaging can predict brain natriuretic peptide in adults with acquired pulmonary hypertension. Int J Cardiol. Shiina, Y., Funabashi, N., Kawakubo, M., Komuro, I., et al 2009; 135 (1): 53-9
  • Right-sided heart wall thickening and delayed enhancement caused by chronic active myocarditis complicated by sustained monomorphic ventricular tachycardia Circulation Hama, Y., Funabashi, N., Kawakubo, M., Komuro, I., et al 2009; 119 (6): e200-3
  • Left atrial compensatory function in subjects with early stage primary hypertension assessed by using left atrial volumetric emptying fraction acquired by transthoracic echocardiography Int J Cardiol. Wakatsuki, Y., Funabashi, N., Kawakubo, M., Komuro, I., et al 2009; 136 (3): 363-7
  • Suitable solutions for reconstituting the ultrasound contrast agent "Levovist" used in contrast echocardiogram: in vitro and in vivo evaluation of the influence of osmotic pressure. Int J Cardiol. Shiina, Y., Funabashi, N., Kawakubo, M., Komuro, I., et al 2009; 136 (3): 335-40
  • Aortic Regurgitation Sogo Rinsho [in Japanese] Kawakubo, M., Komuro, I. 2008; 57 (2): 360-5
  • Cardiac Tumor Sogo Rinsho [in Japanese] Kawakubo, M., Komuro, I. 2008; 57 (12): 2933-40
  • Dilated Cardiomyopathy Sogo Rinsho [in Japanese] Kawakubo, M., Komuro, I. 2008; 57 (6)
  • Postoperative evaluation for Mitral Valve Plasty Echocardiography [in Japanese] Kawakubo, M., Watanabe, H. 2008; 9 (2): 156-65
  • Stress Echocardiography. Kokyu to Junkan [in Japanese] Kawakubo, M., Watanabe, H. 2007; 55 (4): 461-5
  • Appearance of noncompaction-like remodeling of the anatomical right ventricle in a middle-aged subject with modified transposition of the great arteries who did not undergo surgery. Int J Cardiol. Kawakubo, M., Funabashi, N., Komuro, I., et al 2007; 122 (2): 161-3
  • Heart in an eggshell--eggshell appearance calcified constrictive pericarditis demonstrated by three-dimensional images of multislice computed tomography. Int J Cardiol. Kameda, Y., Funabashi, N., Kawakubo, M., Komuro, I., et al 2007; 122 (2): 269-72
  • Evaluation of Coronary Artery using Transthoracic Echocardiography. Eizo Jyoho Medical [in Japanese] Kawakubo, M., Watanabe, H. 2007; 39 (1): 57-67
  • Images in cardiovascular medicine. Demonstration of multislice computed tomography of graft destruction and rupture to the pericardium after replacement of ascending aorta for stanford type-a dissection. Circulation Kawakubo, M., Funabashi, N., Komuro, I., et al 2006; 114 (9): e366-7

Books and Book Chapters


  • The Utility of Three-dimensional Transesophageal Echocardiography. Four Sight TEE View. Clinical Report Vol.4 [in Japanese] Kawakubo, M., Watanabe, H. 2007

Presentations


  • Efficacy and Reproducibility of Left Atrial Volumetric Measurements by Three Dimensional Echocardiography Compared with Conventional Echocardiography and Three Dimensional Multislice-CT

    Time Period

    2008

    Presented To

    19th Annual Scientific Sessions of the American Society of Echocardiography

    Location

    Toronto, Canada

  • Utility of 3D Measurement of Right Ventricular Function by Transthoracic Echocardiogram(TTE) in Acquired Pulmonary Hypertension in Comparison with Brain Natriuretic Peptide and 2D TTE

    Time Period

    2009

    Presented To

    20th Annual Scientific Sessions of the American Society of Echocardiography

    Location

    Washington DC

  • Prognostic Value of Left Atrial Appendage Function for Maintenance of Sinus Rhythm After Catheter Ablation in Atrial Fibrillation

    Abstract Oral Session

    Time Period

    2012

    Presented To

    American Heart Association Scientific Sessions

    Location

    Los Angeles, CA

  • Significance of left atrial appendage function for maintenance of sinus rhythm after catheter ablation in atrial fibrillation

    Time Period

    2011

    Presented To

    The 75nd Annual Scientific Meeting of the Japanese Circulation Society

    Location

    Yokohama, Japan

  • Utility of 3D Measurment of RV Function by Transthoracic Echocardiogram(TTE) in Acquired Pulmonary Hypertension in Comparison with Brain Natriuretic Peptide and 2D TTE

    Time Period

    2009

    Presented To

    The 20th Annual Scientific Meeting of the Japanese Society of Echocardiography

    Location

    Takamatsu, Japan

  • Relationship of natriuretic peptide and transthoracic echocardiographic findings in 102 subjects with Duchenne muscular dystrophy

    Time Period

    2009

    Presented To

    The 20th Annual Scientific Meeting of the Japanese Society of Echocardiography

    Location

    Takamatsu, Japan

  • Utility of Real-time Three Dimensional Echocardiography in Patients with Valvular Heart Disease

    Time Period

    2008

    Presented To

    The 19th Annual Scientific Meeting of the Japanese Society of Echocardiography

    Location

    Kobe, Japan

  • Efficacy and Reproducibility of Left Atrial Volumetric Measurements by Three Dimensional Echocardiography Compared with Conventional Echocardiography and Three Dimensional Multislice-CT

    Time Period

    2008

    Presented To

    The 72nd Annual Scientific Meeting of the Japanese Circulation Society

    Location

    Fukuoka, Japan

  • Quantitative Measurement of Aortic Root Using Three Dimensional Echocardiography for Evaluating Geometrical Change in Patients with Aortic Valve Regurgitation

    Time Period

    2008

    Presented To

    The 72nd Annual Scientific Meeting of the Japanese Circulation Society

    Location

    Fukuoka, Japan

  • Cardiac function in the patients with progressive muscular dystrophy ~The utility of transthoracic Echocardiography for early detection and treatment

    Time Period

    2008

    Presented To

    4th Educational Cardiology in Chiba

    Location

    Chiba, Japan

  • the basis of echocardiography and actual interesting imaging in the patients with various heart disease

    I lectured for students of Chiba University School of Medicine

    Time Period

    2008

    Presented To

    The 3rd Educational Cardiology in Chiba

    Location

    Chiba, Japan

  • Utility of Real-time Three Dimensional Echocardiography

    Time Period

    2008

    Presented To

    Rokko Cardiac Seminar

    Location

    Kobe, Japan

  • How to check pulse by myself

    I lectured for general citizen in Japan

    Time Period

    2009

    Presented To

    Chiba Emergency medical Center Public Seminar

    Location

    Chiba, Japan

  • pathophysiology and therapeutics of cardiology (especially, blood pressure, shock and ischemic heart disease)

    I gave lectures for students in the Saitama Medical University.

    Time Period

    2012

    Location

    Saitama, Japan

  • Quantitative Measurement of Valsalva volume Using Three Dimensional Echocardiography in Patients with Aortic Valve Regurgitation

    Time Period

    2007

    Presented To

    The 55th Annual Scientific Session of the Japanese College of Cardiology

    Location

    Chiba, Japan

  • Clinical Cardiology & Cardiography Conference

    I chaired the meeting

    Time Period

    2007

    Presented To

    Clinical Cardiology & Cardiography Conference

    Location

    Chiba, Japan

  • Diagnosis of malfunction for prosthetic cardiac valve ~Challenge by 3D echocardiography

    Time Period

    2006

    Presented To

    Philips 3D University Seminar

    Location

    Tokyo, Japan

  • The patient with Heparin Induced Thrombocytopenia (HIT) recorded multiple and movable thrombosis using transesophageal echocardiography

    Time Period

    2006

    Presented To

    The 17th Annual Scientific Meeting of the Japanese Society of Echocardiography

    Location

    Saitama, Japan

  • The postoperative patient recorded thrombosis in right atrium moving from vein of lower extremity to pulmonary artery using transesophageal echocardiography

    Time Period

    2005

    Presented To

    The 23th Chiba Cardiovascular Imaging Meeting Seminar

    Location

    Chiba, Japan

  • Appearance of noncompaction-like remodeling of the anatomical right ventricle in a middle-aged subject with modified transposition of the great arteries who did not undergo surgery

    Time Period

    2005

    Presented To

    The 198 th Kanto Local Meeting of the Japanese Circulation Society

    Location

    Saitama, Japan

  • Acute pulmonary thromboembolism

    Time Period

    2004

    Presented To

    Meeting of Cardiology in Tobu

    Location

    Tokyo, Japan

  • Saddle embolism emerged transient and alternating leg paralysis

    Time Period

    2004

    Presented To

    The 1099 th Chiba Medical Annual institute

    Location

    Chiba, Japan

  • Evaluation of arteriosclerosis in the hemodialysis patients with chronic renal failure

    Time Period

    2003

    Presented To

    The 1074 th Chiba Medical Annual institute

    Location

    Chiba, Japan