All Publications


  • Classification of TMS evoked potentials using ERP time signatures and SVM versus deep learning. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference Naze, S., Caggiano, V., Sun, Y., Lucas, M. V., Etkin, A., Kozloski, J. R. 2019; 2019: 3539–42

    Abstract

    Modeling transcranial magnetic stimulation (TMS) evoked potentials (TEP) begins with classification of stereotypical single-pulse TMS responses in order to select validation targets for generative dynamical models. Several dimensionality reduction techniques are commonly in use to extract statistically independent features from experimental data for regression against model parameters. Here, we first designed a 3-dimensional feature space based on commonly described event-related potentials (ERP) from the literature. We then compared classification schemes which take as inputs either the 3D projection space or the original full rank input space. Their ability to discriminate TEP recorded from different brain regions given a stimulus site were evaluated. We show that a deep learning architecture, employing Convolutional Neural Network (CNN) and Multi-Layer Perceptron (MLP), yields better accuracy than the 3D projection and raw TEP input combined with Support Vector Machines. Such supervised feature extraction models may therefore be useful for scoring neural circuit simulations based on their ability to reproduce the underlying dynamical processes responsible for differential TEP responses.

    View details for DOI 10.1109/EMBC.2019.8857583

    View details for PubMedID 31946642

  • Cortical Plasticity in Heroin and Methamphetamine Addiction Lucas, M., Liu, Q., Wu, W., Liu, T., Badami, F., Keller, C., Etkin, A., Yuan, T. ELSEVIER SCIENCE INC. 2019: S296
  • Dissociating the Neural Correlates of Experiencing and Imagining Affective Touch CEREBRAL CORTEX Lucas, M. V., Anderson, L. C., Bolling, D. Z., Pelphrey, K. A., Kaiser, M. D. 2015; 25 (9): 2623–30

    Abstract

    This functional magnetic resonance imaging (fMRI) study examined experiencing and imagining gentle arm and palm touch to determine whether these processes activate overlapping or distinct brain regions. Although past research shows brain responses to experiencing and viewing touch, this study investigates neural processing of touch absent of visual stimulation. C-tactile (CT) nerves, present in hairy skin, respond specifically to caress-like touch. CT-targeted touch activates "social brain" regions including insula, right posterior superior temporal sulcus, amygdala, temporal poles, and orbitofrontal cortex ( McGlone et al. 2012). We addressed whether activations reflect sensory input-driven mechanisms, cognitive-based mechanisms, or both. We identified a functional dissociation between insula regions. Posterior insula responded during experienced touch. Anterior insula responded during both experienced and imagined touch. To isolate stimulus-independent mechanisms recruited during physical experience of CT-targeted touch, we identified regions active to experiencing and imagining such touch. These included amygdala and temporal pole. We posit that the dissociation of insula function suggests posterior and anterior insula involvement in distinct yet interacting processes: coding physical stimulation and affective interpretation of touch. Regions active during experiencing and imagining CT-targeted touch are associated with social processes indicating that imagining touch conjures affective aspects of experiencing such touch.

    View details for DOI 10.1093/cercor/bhu061

    View details for Web of Science ID 000361464000025

    View details for PubMedID 24700583

    View details for PubMedCentralID PMC4537425

  • The Neural Attunement Effects of Oxytocin in Children with Autism Disorders Gordon, I., Vander Wyk, B. C., Lucas, M. V., Cordeaux, C., Bennett, R. H., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., Pelphrey, K. A. ELSEVIER SCIENCE INC. 2014: 84S
  • How to design PET experiments to study neurochemistry: application to alcoholism. The Yale journal of biology and medicine Morris, E. D., Lucas, M. V., Petrulli, J. R., Cosgrove, K. P. 2014; 87 (1): 33–54

    Abstract

    Positron Emission Tomography (PET) (and the related Single Photon Emission Computed Tomography) is a powerful imaging tool with a molecular specificity and sensitivity that are unique among imaging modalities. PET excels in the study of neurochemistry in three ways: 1) It can detect and quantify neuroreceptor molecules; 2) it can detect and quantify changes in neurotransmitters; and 3) it can detect and quantify exogenous drugs delivered to the brain. To carry out any of these applications, the user must harness the power of kinetic modeling. Further, the quality of the information gained is only as good as the soundness of the experimental design. This article reviews the concepts behind the three main uses of PET, the rationale behind kinetic modeling of PET data, and some of the key considerations when planning a PET experiment. Finally, some examples of PET imaging related to the study of alcoholism are discussed and critiqued.

    View details for PubMedID 24600335

    View details for PubMedCentralID PMC3941463

  • Oxytocin enhances brain function in children with autism PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., Pelphrey, K. A. 2013; 110 (52): 20953–58

    Abstract

    Following intranasal administration of oxytocin (OT), we measured, via functional MRI, changes in brain activity during judgments of socially (Eyes) and nonsocially (Vehicles) meaningful pictures in 17 children with high-functioning autism spectrum disorder (ASD). OT increased activity in the striatum, the middle frontal gyrus, the medial prefrontal cortex, the right orbitofrontal cortex, and the left superior temporal sulcus. In the striatum, nucleus accumbens, left posterior superior temporal sulcus, and left premotor cortex, OT increased activity during social judgments and decreased activity during nonsocial judgments. Changes in salivary OT concentrations from baseline to 30 min postadministration were positively associated with increased activity in the right amygdala and orbitofrontal cortex during social vs. nonsocial judgments. OT may thus selectively have an impact on salience and hedonic evaluations of socially meaningful stimuli in children with ASD, and thereby facilitate social attunement. These findings further the development of a neurophysiological systems-level understanding of mechanisms by which OT may enhance social functioning in children with ASD.

    View details for DOI 10.1073/pnas.1312857110

    View details for Web of Science ID 000328858800036

    View details for PubMedID 24297883

    View details for PubMedCentralID PMC3876263