Honors & Awards

  • American Heart Association Predoctoral Fellowship, American Heart Association (2016-2018)

Education & Certifications

  • M.S., University of California, San Diego, Engineering Sciences, Applied Mechanics (2015)
  • M.S, Universitat de Barcelona, Biomedical Engineering (2013)
  • B.S., Universidad Politécnica de Madrid, Aerospace Engineering (2010)

All Publications

  • Hemodynamic variables in aneurysms are associated with thrombotic risk in children with Kawasaki disease. International journal of cardiology Grande Gutierrez, N., Mathew, M., McCrindle, B. W., Tran, J. S., Kahn, A. M., Burns, J. C., Marsden, A. L. 2019


    BACKGROUND: Thrombosis is a major adverse outcome associated with coronary artery aneurysms (CAAs) resulting from Kawasaki disease (KD). Clinical guidelines recommend initiation of anticoagulation therapy with maximum CAA diameter (Dmax) ≥8 mm or Z-score ≥ 10. Here, we investigate the role of aneurysm hemodynamics as a superior method for thrombotic risk stratification in KD patients.METHODS AND RESULTS: We retrospectively studied ten KD patients with CAAs, including five patients who developed thrombosis. We constructed patient-specific anatomic models from cardiac magnetic resonance images and performed computational hemodynamic simulations using SimVascular. Our simulations incorporated pulsatile flow, deformable arterial walls and boundary conditions automatically tuned to match patient-specific arterial pressure and cardiac output. From simulation results, we derived local hemodynamic variables including time-averaged wall shear stress (TAWSS), low wall shear stress exposure, and oscillatory shear index (OSI). Local TAWSS was significantly lower in CAAs that developed thrombosis (1.2 ± 0.94 vs. 7.28 ± 9.77 dynes/cm2, p = 0.006) and the fraction of CAA surface area exposed to low wall shear stress was larger (0.69 ± 0.17 vs. 0.25 ± 0.26%, p = 0.005). Similarly, longer residence times were obtained in branches where thrombosis was confirmed (9.07 ± 6.26 vs. 2.05 ± 2.91 cycles, p = 0.004). No significant differences were found for OSI or anatomical measurements such us Dmax and Z-score. Assessment of thrombotic risk according to hemodynamic variables had higher sensitivity and specificity compared to standard clinical metrics (Dmax, Z-score).CONCLUSIONS: Hemodynamic variables can be obtained non-invasively via simulation and may provide improved thrombotic risk stratification compared to current diameter-based metrics, facilitating long-term clinical management of KD patients with persistent CAAs.

    View details for DOI 10.1016/j.ijcard.2019.01.092

    View details for PubMedID 30728104

  • Computational blood flow simulations in Kawasaki disease patients: Insight into coronary artery aneurysm hemodynamics. Global cardiology science & practice Grande Gutierrez, N., Kahn, A., Burns, J. C., Marsden, A. L. 2017; 2017 (3): e201729

    View details for DOI 10.21542/gcsp.2017.29

    View details for PubMedID 29564350

  • Assessment of Coronary Artery Aneurysms Caused By Kawasaki Disease Using Transluminal Attenuation Gradient Analysis of CT Angiograms Assessment of Coronary Artery Aneurysms Caused By Kawasaki Disease Using Transluminal Attenuation Gradient Analysis of CT Angiograms Grande Gutierrez, N., Shirinsky, O., Gagarina, N., Lyskina, G., Fukazawa, R., Ogawa, S., Burns, J., Marsden, A., Kahn, A. 2017; 120 (4)