Bio


Dr. Pablo Sanchez is post doctoral medical fellow at Stanford University. He earned a degree in physiology at The University of Arizona and received his M.D. from The University of Arizona College of Medicine, in Tucson. He completed Internal Medicine training at Brigham & Women's Hospital/Harvard Medical School, and served as Chief Resident from 2018-2019. During residency, his research focused on clinical outcomes of the complex patient composition in the modern Cardiac Intensive Care Unit. He completed Cardiovascular Medicine fellowship at Stanford and served as Chief Fellow from 2021-2022. He is interested in cardio-pulmonary interactions in Acute Respiratory Distress Syndrome (ARDS). Under the tutelage of Dr. Angela Rogers (Pulmonary Medicine Division) and Dr. Euan Ashley (Cardiovascular Medicine Division), he plans to integrate immune-metabolic biomarker and echocardiographic profiling to identify cardiac dysfunction in ARDS. He plans to pursue additional fellowship training in critical care medicine.

Clinical Focus


  • Fellow
  • Cardiovascular Medicine
  • Critical Care

Honors & Awards


  • Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32), National Institutes of Health (2022)
  • Clinical Research Loan Repayment Program, National Institutes of Health (2022)
  • Stanford Pulmonary Biology Training Program (T32), National Institutes of Health (2022)
  • AHA CLCD Minority Travel Grant, American Heart Association (2019)
  • Resident Mentor Award - Internal Medicine, Brigham and Women's Hospital/Harvard Medical School (2017)
  • Graduating Honors - Research with Distinction, University of Arizona College of Medicine - Tucson (2015)
  • Medical Student of the Year, American College of Physicians - Arizona Chapter (2014)
  • Gold Humanism Honor Society (GHHS), University of Arizona College of Medicine - Tucson (2014)
  • Alpha Omega Alpha Honor Medical Society (AOA), University of Arizona College of Medicine - Tucson (2014)
  • First Place Medical Student Poster, American College of Physicians - Arizona Chapter (2014)
  • Margarito Chavez Grant, Sarver Heart Center (2013)
  • Medical Student Leadership Award and Scholarship, Arizona Latino Medical Association (2013)
  • Community Service Award, Latino Medical Student Association (2012)
  • Office of Outreach and Multicultural Affairs Leadership Award, University of Arizona College of Medicine - Tucson (2012)
  • Van Winkle Award for Excellence in Surgical Research, University of Arizona College of Medicine - Tucson (2011)

Professional Education


  • Chief Fellow, Stanford University, Cardiovascular Medicine (2021)
  • Fellowship, Stanford University School of Medicine, Cardiovascular Medicine Fellowship (2022)
  • Board Certification, American Board of Internal Medicine, Internal Medicine (2019)
  • Chief Resident, Brigham and Women's Hospital, Harvard Medical School, Internal Medicine (2018)
  • Residency, Brigham and Women's Hospital, Harvard Medical School, Internal Medicine (2018)
  • Internship, Brigham and Women's Hospital, Harvard Medical School, Internal Medicine (2016)
  • M.D. with honors, The University of Arizona College of Medicine - Tucson, Medicine (2015)
  • B.S., The University of Arizona, Physiology (2009)

All Publications


  • Training in Critical Care Cardiology Within Critical Care Medicine Fellowship: A Novel Pathway. Journal of the American College of Cardiology O'Brien, C. G., Barnett, C. F., Dudzinski, D. M., Sanchez, P. A., Katz, J. N., Harold, J. G., Hennessey, E. K., Mohabir, P. K. 2022; 79 (6): 609-613

    View details for DOI 10.1016/j.jacc.2021.12.009

    View details for PubMedID 35144752

  • Multimodal deep learning enhances diagnostic precision in left ventricular hypertrophy European Heart Journal - Digital Health Torres Soto, J., Hughes, J., Sanchez, P. A., Perez, M., Ouyang , D., Ashley, E. 2022: 1-10
  • Editor's Choice-Prospective registry of cardiac critical illness in a modern tertiary care Cardiac Intensive Care Unit. European heart journal. Acute cardiovascular care Watson, R. A., Bohula, E. A., Gilliland, T. C., Sanchez, P. A., Berg, D. D., Morrow, D. A. 2019; 8 (8): 755-761

    Abstract

    The changing landscape of care in the Cardiac Intensive Care Unit (CICU) has prompted efforts to redesign the structure and organization of advanced CICUs. Few studies have quantitatively characterized current demographics, diagnoses, and outcomes in the contemporary CICU.We evaluated patients in a prospective observational database, created to support quality improvement and clinical care redesign in an AHA Level 1 (advanced) CICU at Brigham and Women's Hospital, Boston, MA, USA. All consecutive patients (N=2193) admitted from 1 January 2015 to 31 December 2017 were included at the time of admission to the CICU.The median age was 65 years (43% >70 years) and 44% of patients were women. Non-cardiovascular comorbidities were common, including chronic kidney disease (27%), pulmonary disease (22%), and active cancer (13%). Only 7% of CICU admissions were primarily for an acute coronary syndrome, which was the seventh most common individual diagnosis. The top three reasons for admission to the CICU were shock/hypotension (26%), cardiopulmonary arrest (11%), or primary arrhythmia without arrest (9%). Respiratory failure was a primary or major secondary reason for triage to the CICU in 17%. In-hospital mortality was 17.6%.In a tertiary, academic, advanced CICU, patients are elderly with a high burden of non-cardiovascular comorbid conditions. Care has shifted from ACS toward predominantly shock and cardiac arrest, as well as non-ischemic conditions, and the mortality of these conditions is high. These data may be useful to guide cardiac critical care redesign.

    View details for DOI 10.1177/2048872618789053

    View details for PubMedID 30033736

  • Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Patch in Rats With Heart Failure. The Annals of thoracic surgery Lancaster, J. J., Sanchez, P., Repetti, G. G., Juneman, E., Pandey, A. C., Chinyere, I. R., Moukabary, T., LaHood, N., Daugherty, S. L., Goldman, S. 2019; 108 (4): 1169-1177

    Abstract

    To treat chronic heart failure (CHF), we developed a robust, easy to handle bioabsorbable tissue-engineered patch embedded with human neonatal fibroblasts and human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). This patch was implanted on the epicardial surface of the heart covering the previously infarcted tissue.Sprague-Dawley rats (6-8 weeks old) underwent sham surgery (n = 12) or left coronary artery ligation (n = 45). CHF rats were randomized 3 weeks after ligation to CHF control with sham thoracotomy (n = 21), or a fibroblasts/hiPSC-CMs patch (n = 24) was implanted. All sham surgery rats also underwent a sham thoracotomy. At 3 weeks after randomization, hemodynamics, echocardiography, electrophysiologic, and cell survival studies were performed.Patch-treated rats had decreased (P < .05) left ventricular-end diastolic pressure and the time constant of left ventricular relaxation (Tau), increased anterior wall thickness in diastole, and improved echocardiography-derived indices of diastolic function (E/e' [ratio of early peak flow velocity to early peak LV velocity] and e'/a' [ratio of early to late peak left ventricular velocity]). All rats remained in normal sinus rhythm, with no dysrhythmias. Rats treated with the patch showed improved electrical activity. Transplanted hiPSC-CMs were present at 7 days but not detected at 21 days after implantation. The patch increased (P < .05) gene expression of vascular endothelial growth factor, angiopoietin 1, gap junction α-1 protein (connexin 43), β-myosin heavy 7, and insulin growth factor-1 expression in the infarcted heart.Epicardial implantation of a fibroblasts/hiPSC-CMs patch electrically enhanced conduction, lowered left ventricular end-diastolic pressure, and improved diastolic function in rats with CHF. These changes were associated with increases in cytokine expression.

    View details for DOI 10.1016/j.athoracsur.2019.03.099

    View details for PubMedID 31075250

  • Identification of Racial Inequities in Access to Specialized Inpatient Heart Failure Care at an Academic Medical Center. Circulation. Heart failure Eberly, L. A., Richterman, A. n., Beckett, A. G., Wispelwey, B. n., Marsh, R. H., Cleveland Manchanda, E. C., Chang, C. Y., Glynn, R. J., Brooks, K. C., Boxer, R. n., Kakoza, R. n., Goldsmith, J. n., Loscalzo, J. n., Morse, M. n., Lewis, E. F., Abel, S. n., Adams, A. n., Anaya, J. n., Andrews, E. H., Atkinson, B. n., Avutu, V. n., Bachorik, A. n., Badri, O. n., Bailey, M. n., Baird, K. n., Bakshi, S. n., Balaban, D. n., Barshop, K. n., Baumrin, E. n., Bayomy, O. n., Beamesderfer, J. n., Becker, N. n., Berg, D. D., Berman, A. N., Blum, S. M., Boardman, A. P., Boden, K. n., Bonacci, R. A., Brown, S. n., Campbell, K. n., Case, S. n., Cetrone, E. n., Charrow, A. n., Chiang, D. n., Clark, D. n., Cohen, A. J., Cooper, A. n., Cordova, T. n., Cuneo, C. N., de Feria, A. A., Deffenbacher, K. n., DeFilippis, E. M., DeGregorio, G. n., Deutsch, A. J., Diephuis, B. n., Divakaran, S. n., Dorschner, P. n., Downing, N. n., Drescher, C. n., D'Silva, K. M., Dunbar, P. n., Duong, D. n., Earp, S. n., Eckhardt, C. n., Elman, S. A., England, R. n., Everett, K. n., Fedotova, N. n., Feingold-Link, T. n., Ferreira, M. n., Fisher, H. n., Foo, P. n., Foote, M. n., Franco, I. n., Gilliland, T. n., Greb, J. n., Greco, K. n., Grewal, S. n., Grin, B. n., Growdon, M. E., Guercio, B. n., Hahn, C. K., Hasselfeld, B. n., Haydu, E. J., Hermes, Z. n., Hildick-Smith, G. n., Holcomb, Z. n., Holroyd, K. n., Horton, L. n., Huang, G. n., Jablonski, S. n., Jacobs, D. n., Jain, N. n., Japa, S. n., Joseph, R. n., Kalashnikova, M. n., Kalwani, N. n., Kang, D. n., Karan, A. n., Katz, J. T., Kellner, D. n., Kidia, K. n., Kim, J. H., Knowles, S. M., Kolbe, L. n., Kore, I. n., Koullias, Y. n., Kuye, I. n., Lang, J. n., Lawlor, M. n., Lechner, M. G., Lee, K. n., Lee, S. n., Lee, Z. n., Limaye, N. n., Lin-Beckford, S. n., Lipsyc, M. n., Little, J. n., Loewenthal, J. n., Logaraj, R. n., Lopez, D. M., Loriaux, D. n., Lu, Y. n., Ma, K. n., Marukian, N. n., Matias, W. n., Mayers, J. R., McConnell, I. n., McLaughlin, M. n., Meade, C. n., Meador, C. n., Mehta, A. n., Messenger, E. n., Michaelidis, C. n., Mirsky, J. n., Mitten, E. n., Mueller, A. n., Mullur, J. n., Munir, A. n., Murphy, E. n., Nagami, E. n., Natarajan, A. n., Nsahlai, M. n., Nze, C. n., Okwara, N. n., Olds, P. n., Paez, R. n., Pardo, M. n., Patel, S. n., Petersen, A. n., Phelan, L. n., Pimenta, E. n., Pipilas, D. n., Plovanich, M. n., Pong, D. n., Powers, B. W., Rao, A. n., Ramirez Batlle, H. n., Ramsis, M. n., Reichardt, A. n., Reiger, S. n., Rengarajan, M. n., Rico, S. n., Rome, B. N., Rosales, R. n., Rotenstein, L. n., Roy, A. n., Royston, S. n., Rozansky, H. n., Rudder, M. n., Ryan, C. E., Salgado, S. n., Sanchez, P. n., Schulte, J. n., Sekar, A. n., Semenkovich, N. n., Shannon, E. n., Shaw, N. n., Shorten, A. B., Shrauner, W. n., Sinnenberg, L. n., Smithy, J. W., Snyder, G. n., Sreekrishnan, A. n., Stabenau, H. n., Stavrou, E. n., Stergachis, A. n., Stern, R. n., Stone, A. n., Tabrizi, S. n., Tanyos, S. n., Thomas, C. n., Thun, H. n., Torres-Lockhart, K. n., Tran, A. n., Treasure, C. n., Tsai, F. D., Tsaur, S. n., Tschirhart, E. n., Tuwatananurak, J. n., Venkateswaran, R. V., Vishnevetsky, A. n., Wahl, L. n., Wall, A. n., Wallace, F. n., Walsh, E. n., Wang, P. n., Ward, H. B., Warner, L. N., Weeks, L. D., Weiskopf, K. n., Wengrod, J. n., Williams, J. N., Winkler, M. n., Wong, J. L., Worster, D. n., Wright, A. n., Wunsch, C. n., Wynter, J. S., Yarbrough, C. n., Yau, W. Y., Yazdi, D. n., Yeh, J. n., Yialamas, M. A., Yozamp, N. n., Zambrotta, M. n., Zon, R. n. 2019; 12 (11): e006214

    Abstract

    Racial inequities for patients with heart failure (HF) have been widely documented. HF patients who receive cardiology care during a hospital admission have better outcomes. It is unknown whether there are differences in admission to a cardiology or general medicine service by race. This study examined the relationship between race and admission service, and its effect on 30-day readmission and mortality Methods: We performed a retrospective cohort study from September 2008 to November 2017 at a single large urban academic referral center of all patients self-referred to the emergency department and admitted to either the cardiology or general medicine service with a principal diagnosis of HF, who self-identified as white, black, or Latinx. We used multivariable generalized estimating equation models to assess the relationship between race and admission to the cardiology service. We used Cox regression to assess the association between race, admission service, and 30-day readmission and mortality.Among 1967 unique patients (66.7% white, 23.6% black, and 9.7% Latinx), black and Latinx patients had lower rates of admission to the cardiology service than white patients (adjusted rate ratio, 0.91; 95% CI, 0.84-0.98, for black; adjusted rate ratio, 0.83; 95% CI, 0.72-0.97 for Latinx). Female sex and age >75 years were also independently associated with lower rates of admission to the cardiology service. Admission to the cardiology service was independently associated with decreased readmission within 30 days, independent of race.Black and Latinx patients were less likely to be admitted to cardiology for HF care. This inequity may, in part, drive racial inequities in HF outcomes.

    View details for DOI 10.1161/CIRCHEARTFAILURE.119.006214

    View details for PubMedID 31658831

    View details for PubMedCentralID PMC7183732

  • Doppler Assessment of Diastolic Function Reflect the Severity of Injury in Rats With Chronic Heart Failure. Journal of cardiac failure Sanchez, P., Lancaster, J. J., Weigand, K., Mohran, S. E., Goldman, S., Juneman, E. 2017; 23 (10): 753-761

    Abstract

    For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic as opposed to diastolic function. Within the study of diastology, measurements of left ventricular (LV) longitudinal myocardial relaxation have the most validation. Anterior wall radial myocardial tissue relaxation velocities along with mitral valve inflow (MVI) patterns are applicable diastolic parameters in the differentiation between moderate and severe disease in the ischemic rat model of CHF. Myocardial tissue relaxation velocities correlate with traditional measurements of diastolic function (ie, hemodynamics, Tau, and diastolic pressure-volume relationships).Male Sprague-Dawley rats underwent left coronary artery ligation or sham operation. Echocardiography was performed at 3 and 6 weeks after coronary ligation to evaluate LV ejection fraction (EF) and LV diastolic function through MVI patterns (E, A, and E/A) and Doppler imaging of the anterior wall (e' and a'). The rats were categorized into moderate or severe CHF according to their LV EF at 3 weeks postligation. Invasive hemodynamic measurements with solid-state pressure catheters were obtained at the 6-week endpoint. Moderate (N = 20) and severe CHF (N = 22) rats had significantly (P < .05) different EFs, hemodynamics, and diastolic pressure-volume relationships. Early diastolic anterior wall radial relaxation velocities as well as E/e' ratios separated moderate from severe CHF and both diastolic parameters had strong correlations with invasive hemodynamic measurements of diastolic function.Radial anterior wall e' and E/e' can be used for serial assessment of diastolic function in rats with moderate and severe CHF.

    View details for DOI 10.1016/j.cardfail.2017.08.446

    View details for PubMedID 28801075

  • Effect of lysyl oxidase inhibition on angiotensin II-induced arterial hypertension, remodeling, and stiffness. PloS one Eberson, L. S., Sanchez, P. A., Majeed, B. A., Tawinwung, S., Secomb, T. W., Larson, D. F. 2015; 10 (4): e0124013

    Abstract

    It is well accepted that angiotensin II (Ang II) induces altered vascular stiffness through responses including both structural and material remodeling. Concurrent with remodeling is the induction of the enzyme lysyl oxidase (LOX) through which ECM proteins are cross-linked. The study objective was to determine the effect of LOX mediated cross-linking on vascular mechanical properties. Three-month old mice were chronically treated with Ang II with or without the LOX blocker, β -aminopropionitrile (BAPN), for 14 days. Pulse wave velocity (PWV) from Doppler measurements of the aortic flow wave was used to quantify in vivo vascular stiffness in terms of an effective Young's modulus. The increase in effective Young's modulus with Ang II administration was abolished with the addition of BAPN, suggesting that the material properties are a major controlling element in vascular stiffness. BAPN inhibited the Ang II induced collagen cross-link formation by 2-fold and PWV by 44% (P<0.05). Consistent with this observation, morphometric analysis showed that BAPN did not affect the Ang II mediated increase in medial thickness but significantly reduced the adventitial thickness. Since the hypertensive state contributes to the measured in vivo PWV stiffness, we removed the Ang II infusion pumps on Day 14 and achieved normal arterial blood pressures. With pump removal we observed a decrease of the PWV in the Ang II group to 25% above that of the control values (P=0.002), with a complete return to control values in the Ang II plus BAPN group. In conclusion, we have shown that the increase in vascular stiffness with 14 day Ang II administration results from a combination of hypertension-induced wall strain, adventitial wall thickening and Ang II mediated LOX ECM cross-linking, which is a major material source of vascular stiffening, and that the increased PWV was significantly inhibited with co-administration of BAPN.

    View details for DOI 10.1371/journal.pone.0124013

    View details for PubMedID 25875748

    View details for PubMedCentralID PMC4395147