All Publications

  • Segmented targeted least squares estimator for material decomposition in multibin photon-counting detectors. Journal of medical imaging (Bellingham, Wash.) Rajbhandary, P. L., Hsieh, S. S., Pelc, N. J. 2017; 4 (2): 023503-?


    We present a fast, noise-efficient, and accurate estimator for material separation using photon-counting x-ray detectors (PCXDs) with multiple energy bin capability. The proposed targeted least squares estimator (TLSE) is an improvement of a previously described A-table method by incorporating dynamic weighting that allows the variance to be closer to the Cramér-Rao lower bound (CRLB) throughout the operating range. We explore Cartesian and average-energy segmentation of the basis material space for TLSE and show that, compared with Cartesian segmentation, the average-energy method requires fewer segments to achieve similar performance. We compare the average-energy TLSE to other proposed estimators-including the gold standard maximum likelihood estimator (MLE) and the A-table-in terms of variance, bias, and computational efficiency. The variance and bias were simulated in the range of 0 to 6 cm of aluminum and 0 to 50 cm of water with Monte Carlo methods. The Average-energy TLSE achieves an average variance within 2% of the CRLB and mean absolute error of [Formula: see text]. Using the same protocol, the MLE showed variance within 1.9% of the CRLB ratio and average absolute error of [Formula: see text] but was 50 times slower in our implementations. Compared with the A-table method, TLSE gives a more homogenously optimal variance-to-CRLB ratio in the operating region. We show that variance in basis material estimates for TLSE is lower than that of the A-table method by as much as [Formula: see text] in the peripheral region of operating range (thin or thick objects). The TLSE is a computationally efficient and fast method for material separation with PCXDs, with accuracy and precision comparable to the MLE.

    View details for DOI 10.1117/1.JMI.4.2.023503

    View details for PubMedID 28560242

  • Segmented Targeted Least Squares Estimator for Material Decomposition in Multi-Bin PCXDs Medical Imaging - Physics of Medical Imaging Rajbhandary, P. L., Hsieh, S. S., Pelc, N. J. SPIE-INT SOC OPTICAL ENGINEERING. 2014

    View details for DOI 10.1117/12.2043198

    View details for Web of Science ID 000338775800042