Honors & Awards

  • WMIC Travel Award, World Molecular Imaging Society (Sep 2017)
  • Dean’s Postdoctoral Fellowship, Stanford University School of Medicine (May 2014)
  • Chinese Government Award for Outstanding Self-Financed Students Abroad, China Scholarship Council (May 2013)
  • Nanyang Research Scholarship, Nanyang Technological University (May 2009)
  • Honored Graduate Award, Jilin University (June 2009)

Education & Certifications

  • Ph.D, Nanyang Technological University, Bioengineering (2014)
  • B.S., Jilin University, Biotechnology (2009)


  • MOZART: A New Technology for Imaging Tumor Heterogeneity In Vivo, Stanford University School of Medicine


    Stanford, CA, United States

Professional Affiliations and Activities

  • Council member, Stanford University Postdoctoral Association (SURPAS) (2014 - Present)
  • Board member, Association of Chinese Students and Scholars at Stanford (ACSSS) (2014 - Present)
  • UN coordinator, Intern Board of World Health Organization (2013 - 2014)
  • Founder and Chairperson, NTU Graduate Toastmasters Association (2013 - 2014)
  • Founder and President, Nanyang Scholars Toastmasters Club (2013 - 2014)
  • Secretary-General, Student Council of Jilin University School of Life Sciences (2006 - 2007)
  • Deputy Secretary-General, Student Council of Jilin University School of Life Sciences (2005 - 2006)

All Publications

  • In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors SCIENTIFIC REPORTS Si, P., Sen, D., Dutta, R., Yousefi, S., Dalal, R., Winetraub, Y., Liba, O., de la Zerda, A. 2017; 7


    Optical Coherence Tomography (OCT) imaging of living subjects offers increased depth of penetration while maintaining high spatial resolution when compared to other optical microscopy techniques. However, since most protein biomarkers do not exhibit inherent contrast detectable by OCT, exogenous contrast agents must be employed for imaging specific cellular biomarkers of interest. While a number of OCT contrast agents have been previously studied, demonstrations of molecular targeting with such agents in live animals have been historically challenging and notably limited in success. Here we demonstrate for the first time that microbeads (µBs) can be used as contrast agents to target cellular biomarkers in lymphatic vessels and can be detected by OCT using a phase variance algorithm. This molecular OCT method enables in vivo imaging of the expression profiles of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), a biomarker that plays crucial roles in inflammation and tumor metastasis. In vivo OCT imaging of LVYE-1 showed that the biomarker was significantly down-regulated during inflammation induced by acute contact hypersensitivity (CHS). Our work demonstrated a powerful molecular imaging tool that can be used for high resolution studies of lymphatic function and dynamics in models of inflammation, tumor development, and other lymphatic diseases.

    View details for DOI 10.1038/s41598-017-01172-x

    View details for Web of Science ID 000400048500002

    View details for PubMedID 28439123

  • Gold Nanoparticle-Graphite-Like C3N4 Nanosheet Nanohybrids Used for Electrochemiluminescent Immunosensor ANALYTICAL CHEMISTRY Chen, L., Zeng, X., Si, P., Chen, Y., Chi, Y., Kim, D., Chen, G. 2014; 86 (9): 4188-4195


    Two-dimensional graphite-like carbon nitride nanosheets (g-C3N4 NSs) were hybridized with gold nanoparticles (Au NPs) to construct an electrochemiluminescence (ECL) immunosensor. The prepared Au NP-functionalized g-C3N4 NS nanohybrids (Au-g-C3N4 NHs) exhibit strong and stable cathodic ECL activity compared to g-C3N4 NSs due to the important roles of Au NPs in trapping and storing the electrons from the conduction band of g-C3N4 NSs, as well as preventing high energy electron-induced passivation of g-C3N4 NSs. On the basis of the improved ECL stability and ECL peak intensity of the Au-g-C3N4 NHs, a novel ECL immunosensor was developed to detect carcinoembryonic antigen (CEA) as a model target analyte. The ECL immunosensor has a sensitive response to CEA in a linear range of 0.02-80 ng mL(-1) with a detection limit of 6.8 pg mL(-1). Additionally, the proposed immunosensor shows high specificity, good reproducibility, and long-term stability.

    View details for DOI 10.1021/ac403635f

    View details for Web of Science ID 000335719900020

    View details for PubMedID 24707951

  • Fluorescent pH Sensor Based on Ag@SiO2 Core-Shell Nanoparticle ACS APPLIED MATERIALS & INTERFACES Bai, Z., Chen, R., Si, P., Huang, Y., Sun, H., Kim, D. 2013; 5 (12): 5856-5860


    We have demonstrated a novel method for the preparation of a fluorescence-based pH sensor by combining the plasmon resonance band of Ag core and pH sensitive dye (HPTS). A thickness-variable silica shell is placed between Ag core and HPTS dye to achieve the maximum fluorescence enhancement. At the shell thickness of 8 nm, the fluorescence intensity increases 4 and 9 times when the sensor is excited at 405 and 455 nm, respectively. At the same time, the fluorescence intensity shows a good sensitivity toward pH value in the range of 5-9, and the ratio of emission intensity at 513 nm excited at 455 nm to that excited at 405 nm versus the pH value in the range of 5-9 is determined. It is believed that the present pH sensor has the potential for determining pH real time in the biological sample.

    View details for DOI 10.1021/am401528w

    View details for Web of Science ID 000321237000062

    View details for PubMedID 23716502

  • Electrodeposition of hierarchical MnO2 spheres for enzyme immobilization and glucose biosensing JOURNAL OF MATERIALS CHEMISTRY B Si, P., Chen, P., Kim, D. 2013; 1 (21): 2696-2700

    View details for DOI 10.1039/c3tb20341g

    View details for Web of Science ID 000318568600002

  • Nanomaterials for electrochemical non-enzymatic glucose biosensors RSC ADVANCES Si, P., Huang, Y., Wang, T., Ma, J. 2013; 3 (11): 3487-3502

    View details for DOI 10.1039/c2ra22360k

    View details for Web of Science ID 000314973800002

  • A hierarchically structured composite of Mn3O4/3D graphene foam for flexible nonenzymatic biosensors JOURNAL OF MATERIALS CHEMISTRY B Si, P., Dong, X., Chen, P., Kim, D. 2013; 1 (1): 110-115

    View details for DOI 10.1039/c2tb00073c

    View details for Web of Science ID 000314784900012

  • Hierarchically Structured One-Dimensional TiO2 for Protein Immobilization, Direct Electrochemistry, and Mediator-Free Glucose Sensing ACS NANO Si, P., Ding, S., Yuan, J., Lou, X. W., Kim, D. 2011; 5 (9): 7617-7626


    A novel one-dimensional hierarchically structured TiO(2) (1DHS TiO(2)) was synthesized by a solvothermal method using multiwalled carbon nanotubes (MWCNTs) as a template and evaluated for the immobilization of protein and biosensing applications. Characterization studies showed that the 1DHS TiO(2) possessed an anatase crystalline structure and a large surface area with narrow pore size distribution. Fast direct electron transfer was observed for glucose oxidase (GOx) immobilized on the 1DHS TiO(2), and excellent electrocatalytic performance for glucose detection can be obtained without a mediator. The glucose sensor based on the GOx/1DHS TiO(2)-modified electrode had a high sensitivity of 9.90 μA mM(-1) cm(-2) and a low detection limit of 1.29 μM. The fabricated biosensor displayed good selectivity and long-term stability, indicating that the novel structured TiO(2) is a promising material for the immobilization of biomolecules and the fabrication of third-generation biosensors.

    View details for DOI 10.1021/nn202714c

    View details for Web of Science ID 000295187400098

    View details for PubMedID 21866956

  • Highly stable and sensitive glucose biosensor based on covalently assembled high density Au nanostructures BIOSENSORS & BIOELECTRONICS Si, P., Kannan, P., Guo, L., Son, H., Kim, D. 2011; 26 (9): 3845-3851
  • An electrochemically formed three-dimensional structure of polypyrrole/graphene nanoplatelets for high-performance supercapacitors RSC ADVANCES Si, P., Ding, S., Lou, X. (., Kim, D. 2011; 1 (7): 1271-1278

    View details for DOI 10.1039/c1ra00519g

    View details for Web of Science ID 000296388800018

  • Selective and sensitive determination of dopamine by composites of polypyrrole and graphene modified electrodes ANALYST Si, P., Chen, H., Kannan, P., Kim, D. 2011; 136 (24): 5134-5138


    A novel method is developed to fabricate the polypyrrole (PPy) and graphene thin films on electrodes by electrochemical polymerization of pyrrole with graphene oxide (GO) as a dopant, followed by electrochemical reduction of GO in the composite film. The composite of PPy and electrochemically reduced graphene oxide (eRGO)-modified electrode is highly sensitive and selective toward the detection of dopamine (DA) in the presence of high concentrations of ascorbic acid (AA) and uric acid (UA). The sensing performance of the PPy/eRGO-modified electrode is investigated by differential pulse voltammetry (DPV), revealing a linear range of 0.1-150 μM with a detection limit of 23 nM (S/N = 3). The practical application of the PPy/eRGO-modified electrode is successfully demonstrated for DA determination in human blood serum.

    View details for DOI 10.1039/c1an15772h

    View details for Web of Science ID 000297223000005

    View details for PubMedID 22010122