Peter is a PhD candidate in Bioengineering at Stanford University. His thesis research with Prof. Christina Smolke focuses on the intersection of synthetic biology and regenerative medicine where he is developing a novel RNA-based platform for control of mammalian cell fate decisions. He also works with Dr. Megan J. Palmer on biosecurity and biopolicy projects, including the design of programs that educate government stakeholders on biosecurity threats. Peter is originally from La Mesa, CA and holds an MS in Bioengineering from Stanford University and a BS in Bioengineering from the University of California, San Diego. He is supported by a Graduate Research Fellowship award from the National Science Foundation. When he takes a break from science, Peter loves outdoor adventures, cheap international flights, and mixing live music.

Honors & Awards

  • NSF Fellow, National Science Foundation, Graduate Research Fellowship Program (2016)
  • David K. Jordan Award, Warren College, UC San Diego (2015)
  • Amgen Scholar, Amgen Foundation/UC San Diego (2014)
  • Gayle G. Arnold Award for Best Scientific Paper, American Academy for Cerebral Palsy and Developmental Medicine (2013)
  • Quarter Provost Honors, Warren College, UC San Diego (2012-2015)

Education & Certifications

  • Master of Science, Stanford University, BIOE-MS (2017)
  • B.S., UC San Diego, La Jolla, CA, Bioengineering: Biotechnology (2015)

Stanford Advisors

Service, Volunteer and Community Work

  • Student Representative, Warren College, UC San Diego (September 2011 - June 2015)

    Convened with the Provost of Warren College to discuss student issues including the creation of an undergraduate interdisciplinary research journal for Warren College


    La Jolla, CA

  • Co-founder and Chief Editor, Warren College, UC San Diego (January 2014 - June 2015)

    Co-founded an undergraduate interdisciplinary research journal for Warren College students


    La Jolla, CA

  • Student Representative, Jacobs School of Engineering, UC San Diego (February 2014 - June 2015)

    Met with other student leaders to review and allocate monetary funds for students to travel and attend engineering-related conferences


    La Jolla, CA

  • Discussion Leader, Warren College, UC San Diego (September 2014 - December 2014)

    Lead weekly discussion section with 20 incoming freshman students. Duties included developing lesson plans, assessing student performance, participating in weekly meeting with faculty lecturer, holding weekly office hours


    La Jolla, CA

  • Lead Staff Counselor, Indian Hills Camp (June 2011 - August 2012)

    Worked with Guest Counselors and assisted full-time staff in a leadership capacity at a summer camp for children


    Jamul, California

Lab Affiliations

2017-18 Courses

Work Experience

  • Undergraduate Researcher, Muscle Physiology Lab, Departments of Bioengineering/Orthopaedic Surgery, UC San Diego (September 2012 - August 2015)


    La Jolla, CA

All Publications

  • Massively parallel RNA device engineering in mammalian cells with RNA-Seq. Nature communications Xiang, J. S., Kaplan, M., Dykstra, P., Hinks, M., McKeague, M., Smolke, C. D. 2019; 10 (1): 4327


    Synthetic RNA-based genetic devices dynamically control a wide range of gene-regulatory processes across diverse cell types. However, the limited throughput of quantitative assays in mammalian cells has hindered fast iteration and interrogation of sequence space needed to identify new RNA devices. Here we report developing a quantitative, rapid and high-throughput mammalian cell-based RNA-Seq assay to efficiently engineer RNA devices. We identify new ribozyme-based RNA devices that respond to theophylline, hypoxanthine, cyclic-di-GMP, and folinic acid from libraries of ~22,700 sequences in total. The small molecule responsive devices exhibit low basal expression and high activation ratios, significantly expanding our toolset of highly functional ribozyme switches. The large datasets obtained further provide conserved sequence and structure motifs that may be used for rationally guided design. The RNA-Seq approach offers a generally applicable strategy for developing broad classes of RNA devices, thereby advancing the engineering of genetic devices for mammalian systems.

    View details for DOI 10.1038/s41467-019-12334-y

    View details for PubMedID 31548547

  • Reduced skeletal muscle satellite cell number alters muscle morphology after chronic stretch but allows limited serial sarcomere addition. Muscle & nerve Kinney, M. C., Dayanidhi, S., Dykstra, P. B., McCarthy, J. J., Peterson, C. A., Lieber, R. L. 2017; 55 (3): 384–92


    Muscles add sarcomeres in response to stretch, presumably to maintain optimal sarcomere length. Clinical evidence from patients with cerebral palsy, who have both decreased serial sarcomere number and reduced satellite cells (SCs), suggests a hypothesis that SCs may be involved in sarcomere addition.A transgenic Pax7-DTA mouse model underwent conditional SC depletion, and their soleii were then stretch-immobilized to assess the capacity for sarcomere addition. Muscle architecture, morphology, and extracellular matrix (ECM) changes were also evaluated.Mice in the SC-reduced group achieved normal serial sarcomere addition in response to stretch. However, muscle fiber cross-sectional area was significantly smaller and was associated with hypertrophic ECM changes, consistent with fibrosis.While a reduced SC population does not hinder serial sarcomere addition, SCs play a role in muscle adaptation to chronic stretch that involves maintenance of both fiber cross-sectional area and ECM structure. Muscle Nerve 55: 384-392, 2017.

    View details for DOI 10.1002/mus.25227

    View details for PubMedID 27343167

    View details for PubMedCentralID PMC5183525

  • Reduced satellite cell number in situ in muscular contractures from children with cerebral palsy JOURNAL OF ORTHOPAEDIC RESEARCH Dayanidhi, S., Dykstra, P. B., Lyubasyuk, V., McKay, B. R., Chambers, H. G., Lieber, R. L. 2015; 33 (7): 1039-1045


    Satellite cells (SC) are quiescent adult muscle stem cells critical for postnatal development. Children with cerebral palsy have impaired muscular growth and develop contractures. While flow cytometry previously demonstrated a reduced SC population, extracellular matrix abnormalities may influence the cell isolation methods used, systematically isolating fewer cells from CP muscle and creating a biased result. Consequently, the purpose of this study was to use immunohistochemistry on serial muscle sections to quantify SC in situ. Serial cross-sections from human gracilis muscle biopsies (n = 11) were labeled with fluorescent antibodies for Pax7 (SC transcriptional marker), laminin (basal lamina), and 4',6-diamidino-2-phenylindole (nuclei). Fluorescence microscopy under high magnification was used to identify SC based on labeling and location. Mean SC/100 myofibers was reduced by ∼70% (p < 0.001) in children with CP (2.89 ± 0.39) compared to TD children (8.77 ± 0.79). Furthermore, SC distribution across fields was different (p < 0.05) with increased percentage of SC in fields being solitary cells (p < 0.01) in children with CP. Quantification of SC number in situ, without any other tissue manipulation confirms children with spastic CP have a reduced number. This stem cell loss may, in part, explain impaired muscle growth and apparent decreased responsiveness of CP muscle to exercise.

    View details for DOI 10.1002/jor.22860

    View details for Web of Science ID 000355333600014

    View details for PubMedID 25732238