Bio


Dr. Khalifehzadeh received a dual Ph.D. in Chemical Engineering and Nanotechnology & Molecular Engineering from the University of Washington (UW) in 2018. Her thesis research was focused on design of new classes of degradable polymers for the next generation of cardiovascular stents. Throughout her graduate study, she received multiple prestigious awards such as Pre-doctoral Clinical Research Training (TL1) scholarship from National Center for Advancing Translational Science at NIH, Society for Biomaterials (SFB) travel award, Dean of Engineering Scholarship and Graduate School Fund for Excellence and Innovation (GSFEI, UW). She is currently a T32 postdoctoral research fellow in the laboratories of Prof. Zhenan Bao and Prof. Sam Gambhir at Stanford University. Her interdisciplinary research lies at the interface of engineering and translational medicine and focuses on the development of wireless, implantable or wearable bioelectronics for early disease diagnosis and therapy.

Honors & Awards


  • Cancer-Translational Nanotechnology Training (Cancer-TNT) Program, Stanford (2019- 2021)
  • Honorable mention for an outstanding contribution to the Society For Biomaterials, Society For Biomaterials (2018)
  • National Institute of Health (NIH) fellowship, BloodSurf workshop (2017)
  • Graduate School Fund for Excellence and Innovation (GSFEI) Travel Award, University of Washington (2016&2018)
  • NIH (TL1) fellowship, Institute of Translational Health Sciences (ITHS) (2016)
  • World Biomaterial Congress (WBC) Travel Award, Society for Biomaterials (2016)
  • Commentary about “Biomaterials” selected as Next Generation Voices, Science magazine (2014)
  • Dean of Engineering scholarship, University of Texas at Arlington (2008-2010)

Professional Education


  • Doctor of Philosophy, University of Washington (2018)

Patents


  • BD Ratner, R Khalifehzadeh, E Naeemi, CU Lee, AJ Boydston. "United States Patent 15678581 Halogenated cyclic diesters, related polymers, and methods for their preparation and use", Nov 30, 2017

All Publications


  • Trifluoromethyl-functionalized poly(lactic acid): a fluoropolyester designed for blood contact applications BIOMATERIALS SCIENCE Khalifehzadeh, R., Ratner, B. D. 2019; 7 (9): 3764–78

    Abstract

    Fluorinated polymers are strong candidates for development of new cardiovascular medical devices, due to their lower thrombogenicity as compared to other polymers used for cardiovascular implants. Few studies have reported the development of fluorinated polyesters and their potential in blood contact applications has never been examined. In this study, we developed a versatile method for preparing trifluoromethyl-functionalized poly(lactic acid) that can be potentially extended to prepare a new class of polyesters with various halogen or halocarbon substitutions. The resulting fluorinated polymer was hydrophobic relative to poly(lactic acid) and extracts from this polymer showed no in vitro cytotoxicity to NIH-3T3 mouse fibroblast cells. A preliminary consideration of the blood interactions of the CF3-functionalized polyester was evaluated by measuring the amount of the adsorbed albumin and fibrinogen from human blood plasma. The fluorinated polyester adsorbed and retained higher amounts of albumin and fibrinogen with a higher albumin/fibrinogen ratio as compared to poly(lactic acid), suggesting enhanced hemocompatibility. Plasma protein adsorption is the first event that occurs seconds after device implantation and controlling the adsorbed proteins will dictate the performance of medical implants.

    View details for DOI 10.1039/c9bm00353c

    View details for Web of Science ID 000482087100019

    View details for PubMedID 31342016

  • DNA-Templated Strontium-Doped Calcium Phosphate Nanoparticles for Gene Delivery in Bone Cells ACS BIOMATERIALS SCIENCE & ENGINEERING Khalifehzadeh, R., Arami, H. 2019; 5 (7): 3201–11
  • Surface fluorination of polylactide as a path to improve platelet associated hemocompatibility ACTA BIOMATERIALIA Khalifehzadeh, R., Ciridon, W., Ratner, B. D. 2018; 78: 23–35

    Abstract

    Surface-induced thrombosis is still a significant clinical concern for many types of blood-contacting medical devices. In particular, protein adsorption and platelet adhesion are important events due to their ability to trigger the coagulation cascade and initiate thrombosis. Poly(lactic acid) (PLA) has been the predominant polymer used for making bioresorbable stents. Despite long-term advantages, these stents are associated with higher rates of early thrombosis compared with permanent metallic stents. To address this issue, we modified the surface of PLA with a perfluoro compound facilitated by surface activation using radio frequency (RF) plasma. Fluoropolymers have been extensively used in blood contacting materials, such as blood vessel replacements due to their reduced thrombogenicity and reduced platelet reactivity. The compositions of plasma-treated surfaces were determined by electron spectroscopy for chemical analysis (ESCA). Also, contact angle measurements, cell cytotoxicity and the degradation profile of the treated polymers are presented. Finally, relevant blood compatibility parameters, including plasma protein adsorption, platelet adhesion and morphology, were evaluated. We hypothesized that tight binding of adsorbed albumin by fluoropolymers enhances its potential for blood-contacting applications.Although bioresorbable stents made from poly(lactic acid) (PLA) may have long-term clinical advantages, they have shown higher rates of early thrombosis as compared with permanent metallic stents. To improve the thromboresistance of PLA, we developed a novel method for surface fluorination of this polymer with a perfluoro compound. Fluoropolymers (e.g., expanded polytetrafluoroethylene) have long been used in blood-contacting applications due to their satisfactory clinical performance. This is the first report of PLA surface fluorination which might be applied to the fabrication of a new generation of fluorinated PLA stents with improved platelet interaction, tunable degradability and drug release capabilities. Also, we describe a general strategy for improving the platelet interactions with biomaterials based on albumin retention.

    View details for DOI 10.1016/j.actbio.2018.07.042

    View details for Web of Science ID 000445990200003

    View details for PubMedID 30036719

  • Facile Synthesis of Fluorine-Substituted Polylactides and Their Amphiphilic Block Copolymers MACROMOLECULES Lee, C., Khalifehzadeh, R., Ratner, B., Boydston, A. J. 2018; 51 (4): 1280–89
  • Rapid formation of hydroxyapatite nanostrips via microwave irradiation JOURNAL OF ALLOYS AND COMPOUNDS Arami, H., Mohajerani, M., Mazloumi, M., Khalifehzadeh, R., Lak, A., Sadrnezhaad, S. K. 2009; 469 (1-2): 391-394
  • Self-assembled nanostructured ZnO hollow spheres with UVA luminescence ADVANCES IN APPLIED CERAMICS Arami, H., Mazloumi, M., Khalifehzadeh, R., Sadrnezhaad, S. K. 2009; 108 (2): 73-77
  • Effect of predeformation and heat treatment conditions in the SIMA process on microstructural and mechanical properties of A319 aluminum alloy JOURNAL OF ALLOYS AND COMPOUNDS Arami, H., Khalifehzadeh, R., Keyvan, H., Khomamizadeh, F. 2009; 468 (1-2): 130-135
  • Synthesis of γ-Alumina Nanopowders from Synthetic Bayer Liquor and its Application for Oil and Gas Industries JOURNAL OF NANOCOMPOSITE MATERIALS RESEARCH (JNMR) Sadrnezhaad , S., Mazloumi , M., Arami , H., Khalifehzadeh , R. 2009 ; 1 (2): 71-76
  • Surfactant free hydrothermal formation of Pb3O4 nanorods JOURNAL OF ALLOYS AND COMPOUNDS Arami, H., Mazloumi, M., Khalifehzadeh, R., Sadrnezhaad, S. K. 2008; 466 (1-2): 323-325
  • Bundles of self-assembled boehmite nanostrips from a surfactant free hydrothermal route JOURNAL OF ALLOYS AND COMPOUNDS Arami, H., Mazloumi, M., Khalifehzadeh, R., Sadrnezhaad, S. K. 2008; 461 (1-2): 551-554
  • ELECTROCHEMICAL DEPOSITION OF FLOWER-LIKE NICKEL NANOSTRUCTURES ON WELL-DEFINED n-Si(111):H INTERNATIONAL JOURNAL OF ENGINEERING Torabi, M., Khalifehzadeh, R., Arami, H., Sadrnezhaad, S. K. 2008; 21 (2): 177–82
  • Microporosity control and thermal-fatigue resistance of A319 aluminum foundry alloy MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING Arami, H., Khalifetizadeh, R., Akbari, M., Khomamizadeh, F. 2008; 472 (1-2): 107-114
  • Self-assembled dahlia-like cadmium hydrogen phosphate hydrate nanostructures as templates for cadmium hydroxyapatite hexagonal prisms JOURNAL OF CRYSTAL GROWTH Arami, H., Mazloumi, M., Khalifehzadeh, R., Lak, A., Sadrnezhaad, S. K. 2007; 309 (1): 37-42
  • Electron beam-induced "nanocalcination" of boehmite nanostrips to mesoporous alpha-alumina phase JOURNAL OF THE AMERICAN CERAMIC SOCIETY Arami, H., Mazloumi, M., Khalifehzadeh, R., Khatiboleslam, S., Sadrnezhaadw, S. K. 2007; 90 (10): 3311-3313
  • Prediction of the effect of vacuum sintering conditions on porosity and hardness of porous NiTi shape memory alloy using ANFIS COMPUTATIONAL MATERIALS SCIENCE Khalifehzadeh, R., Forouzan, S., Arami, H., Sadrnezhaad, S. K. 2007; 40 (3): 359-365
  • Polypyrrole/multiwall carbon nanotube nanocomposites electropolymerized on copper substrate MATERIALS LETTERS Arami, H., Mazloumi, M., Khalifehzadeh, R., Emami, S. H., Sadrnezhaad, S. K. 2007; 61 (22): 4412-4415
  • Sonochemical preparation of TiO2 nanoparticles MATERIALS LETTERS Arami, H., Mazloumi, M., Khalifehzadeh, R., Sadmezhaad, S. K. 2007; 61 (23-24): 4559-4561
  • Studies on synthesis of alumina nanopowder from synthetic Bayer liquor MATERIALS RESEARCH BULLETIN Mazloumi, M., Arami, H., Khalifehzadeh, R., Sadrnezhaad, S. K. 2007; 42 (6): 1004-1009
  • Alumina nanopowder production from synthetic Bayer liquor JOURNAL OF THE AMERICAN CERAMIC SOCIETY Mazloumi, M., Khalifehzadeh, R., Sadrnezhaad, S. K., Arami, H. 2006; 89 (12): 3654-3657
  • Powder metallurgical fabrication and characterization of nanostructured porous NiTi shape-memory alloy MATERIALS AND MANUFACTURING PROCESSES Sadrnezhaad, S. K., Arami, H., Keivan, H., Khalifezadeh, R. 2006; 21 (8): 727-735