Doctor of Medicine, Duke University (2010)
Bachelor of Science, University of Chicago (2001)
Doctor of Philosophy, Duke University (2008)
Tzielan Lee, Postdoctoral Faculty Sponsor
Current Research and Scholarly Interests
I am working on the antibody and T cell repertoires in systemic lupus erythematosus.
Bill Robinson, (1/1/2015)
Pediatric plastic bronchitis: case report and retrospective comparative analysis of epidemiology and pathology.
Case reports in pulmonology
2013; 2013: 649365-?
Plastic bronchitis (PB) is a pathologic condition in which airway casts develop in the tracheobronchial tree causing airway obstruction. There is no standard treatment strategy for this uncommon condition. We report an index patient treated using an emerging multimodal strategy of directly instilled and inhaled tissue plasminogen activator (t-PA) as well as 13 other cases of PB at our institution between 2000 and 2012. The majority of cases (n = 8) occurred in patients with congenital heart disease. Clinical presentations, treatments used, histopathology of the casts, and patient outcomes are reviewed. Further discussion is focused on the epidemiology of plastic bronchitis and a systematic approach to the histologic classification of casts. Comorbid conditions identified in this study included congenital heart disease (8), pneumonia (3), and asthma (2). Our institutional prevalence rate was 6.8 per 100,000 patients, and our case fatality rate was 7%.
View details for DOI 10.1155/2013/649365
View details for PubMedID 23662235
The Metabolic Regulator ERR alpha, a Downstream Target of HER2/IGF-1R, as a Therapeutic Target in Breast Cancer
2011; 20 (4): 500-510
A genomic signature designed to assess the activity of the estrogen-related receptor alpha (ERRα) was used to profile more than 800 breast tumors, revealing a shorter disease-free survival in patients with tumors exhibiting elevated receptor activity. Importantly, this signature also predicted the ability of an ERRα antagonist, XCT790, to inhibit proliferation in cellular models of breast cancer. Using a chemical genomic approach, it was determined that activation of the Her2/IGF-1R signaling pathways and subsequent C-MYC stabilization upregulate the expression of peroxisome proliferator-activated receptor gamma coactivator-1 beta (PGC-1β), an obligate cofactor for ERRα activity. PGC-1β knockdown in breast cancer cells impaired ERRα signaling and reduced cell proliferation, implicating a functional role for PGC-1β/ERRα in the pathogenesis of breast cancers.
View details for DOI 10.1016/j.ccr.2011.08.023
View details for Web of Science ID 000296121300011
View details for PubMedID 22014575