All Publications

  • Novel therapeutic avenues for cholangiocarcinoma treatment: A meta-analysis Aljabban, N., Aljabban, J., Gurakar, M., Khorfan, K., Syed, S. A., Gayar, A. AMER SOC CLINICAL ONCOLOGY. 2020
  • Meta-analysis Demonstrates Altered Antigen Presentation and Maladaptive Immune Response in Chronic Urticaria Aljabban, J., Mukhtar, M., Syed, S., Syed, S., Aljabban, N., Hoffman, K., Mohammed, M., Allarakhia, Z., Sura, H., Panahiazar, M., Hadley, D. MOSBY-ELSEVIER. 2020: AB202
  • Tumorigenesis Related Gene Identification in Dermatomyositis Using Meta-Analysis Aljabban, J., Syed, S., Syed, S., Hoffman, K., Hasan, L., Adapa, N., Allarakhia, Z., Hadley, D., Aljabban, M., Jarjourg, W. WILEY. 2019
  • Multi-Organ System Meta-Analytic Approach to Investigating Sarcoidosis Aljabban, J., Syed, S., Syed, S., Adapa, N., Hasan, L., Allarakhia, Z., Hadley, D., Aljabban, M., Jarjour, W. WILEY. 2019
  • Tripartite Motif (TRIM) Gene Family Expression in Dermatomyositis Aljabban, J., Syed, S., Syed, S., Sahenk, Z., Weisleder, N., McElhanon, K., Hoffman, K., Adapa, N., Allarakhia, Z., Hasan, L., Hadley, D., Aljabban, M., Jarjourn, W. WILEY. 2019
  • Assessing the potential of immunotherapy in treating chronic lymph ocytic leukemia through meta-analysis. Aljabban, J., Allen, D., McDermott, S., Wanner, R., Salhi, H., Syed, S. A., Chen, D., Hadley, D., Khoulani, D. AMER SOC CLINICAL ONCOLOGY. 2019
  • Meta-analysis utilizing public data suggests role of innate immunity in the pathogenesis of hurthle cell carcinoma (HCC). Allen, D., Wanner, R., McDermott, S., Aljabban, J., Syed, S., Elmaraghy, C., Hadley, D. AMER SOC CLINICAL ONCOLOGY. 2019
  • Elucidating the pathogenesis of esophageal adenocarcinoma through meta-analysis of public data. Khorfan, K., Aljabban, J., Syed, S., Salhi, H., Adejare, A., Suara, H., Allarakhia, Z., Panahiazar, M., Hadley, D. AMER SOC CLINICAL ONCOLOGY. 2019
  • S-Palmitoylation Sorts Membrane Cargo for Anterograde Transport in the Golgi DEVELOPMENTAL CELL Ernst, A. M., Syed, S. A., Zaki, O., Bottanelli, F., Zheng, H., Hacke, M., Xi, Z., Rivera-Molina, F., Graham, M., Rebane, A. A., Bjorkholm, P., Baddeley, D., Toomre, D., Pincet, F., Rothman, J. E. 2018; 47 (4): 479-+


    While retrograde cargo selection in the Golgi is known to depend on specific signals, it is unknown whether anterograde cargo is sorted, and anterograde signals have not been identified. We suggest here that S-palmitoylation of anterograde cargo at the Golgi membrane interface is an anterograde signal and that it results in concentration in curved regions at the Golgi rims by simple physical chemistry. The rate of transport across the Golgi of two S-palmitoylated membrane proteins is controlled by S-palmitoylation. The bulk of S-palmitoylated proteins in the Golgi behave analogously, as revealed by click chemistry-based fluorescence and electron microscopy. These palmitoylated cargos concentrate in the most highly curved regions of the Golgi membranes, including the fenestrated perimeters of cisternae and associated vesicles. A palmitoylated transmembrane domain behaves similarly in model systems.

    View details for DOI 10.1016/j.devcel.2018.10.024

    View details for Web of Science ID 000450620800013

    View details for PubMedID 30458139

    View details for PubMedCentralID PMC6251505