Saisneha Koppaka

All Publications

• Fabrication of a silicon mu Dicer for uniform microdissection of tissue samples APPLIED PHYSICS LETTERS Cordts, S. C., Castano, N., Koppaka, S., Tang, S. Y. 2021; 119 (1)

  View details for DOI 10.1063/5.0053792

  View details for Web of Science ID 000691551300002

• Fomite Transmission, Physicochemical Origin of Virus-Surface Interactions, and Disinfection Strategies for Enveloped Viruses with Applications to SARS-CoV-2. ACS omega Castano, N., Cordts, S. C., Kurosu Jalil, M., Zhang, K. S., Koppaka, S., Bick, A. D., Paul, R., Tang, S. K. 2021; 6 (10): 6509–27

  Abstract

  Inanimate objects or surfaces contaminated with infectious agents, referred to as fomites, play an important role in the spread of viruses, including SARS-CoV-2, the virus responsible for the COVID-19 pandemic. The long persistence of viruses (hours to days) on surfaces calls for an urgent need for effective surface disinfection strategies to intercept virus transmission and the spread of diseases. Elucidating the physicochemical processes and surface science underlying the adsorption and transfer of virus between surfaces, as well as their inactivation, is important for understanding how diseases are transmitted and for developing effective intervention strategies. This review summarizes the current knowledge and underlying physicochemical processes of virus transmission, in particular via fomites, and common disinfection approaches. Gaps in knowledge and the areas in need of further research are also identified. The review focuses on SARS-CoV-2, but discussion of related viruses is included to provide a more comprehensive review given that much remains unknown about SARS-CoV-2. Our aim is that this review will provide a broad survey of the issues involved in fomite transmission and intervention to a wide range of readers to better enable them to take on the open research challenges.

  View details for DOI 10.1021/acsomega.0c06335

  View details for PubMedID 33748563

• Vision-based Autonomous Disinfection of High-touch Surfaces in Indoor Environments Roelofs, S., Landry, B., Jalil, M., Martin, A., Koppaka, S., Tang, S. Y., Pavone, M., IEEE IEEE. 2021: 263-270

  View details for DOI 10.23919/ICCAS52745.2021.9649848

  View details for Web of Science ID 000750950700031

• Fabrication of 3D Micro-Blades for the Cutting of Biological Structures in a Microfluidic Guillotine. Micromachines Koppaka, S., Zhang, K. S., Kurosu Jalil, M., Blauch, L. R., Tang, S. K. 2021; 12 (9)

  Abstract

  Micro-blade design is an important factor in the cutting of single cells and other biological structures. This paper describes the fabrication process of three-dimensional (3D) micro-blades for the cutting of single cells in a microfluidic "guillotine" intended for fundamental wound repair and regeneration studies. Our microfluidic guillotine consists of a fixed 3D micro-blade centered in a microchannel to bisect cells flowing through. We show that the Nanoscribe two-photon polymerization direct laser writing system is capable of fabricating complex 3D micro-blade geometries. However, structures made of the Nanoscribe IP-S resin have low adhesion to silicon, and they tend to peel off from the substrate after at most two times of replica molding in poly(dimethylsiloxane) (PDMS). Our work demonstrates that the use of a secondary mold replicates Nanoscribe-printed features faithfully for at least 10 iterations. Finally, we show that complex micro-blade features can generate different degrees of cell wounding and cell survival rates compared with simple blades possessing a vertical cutting edge fabricated with conventional 2.5D photolithography. Our work lays the foundation for future applications in single cell analyses, wound repair and regeneration studies, as well as investigations of the physics of cutting and the interaction between the micro-blade and biological structures.

  View details for DOI 10.3390/mi12091005

  View details for PubMedID 34577648

• Numerical Modelling of Non-Linearities in MEMS Resonators JOURNAL OF MICROELECTROMECHANICAL SYSTEMS Zega, V., Gattere, G., Koppaka, S., Alter, A., Vukasin, G. D., Frangi, A., Kenny, T. W. 2020; 29 (6): 1443–54

  View details for DOI 10.1109/JMEMS.2020.3026085

  View details for Web of Science ID 000595526700006

• Clocking the formation of today's largest galaxies: wide field integral spectroscopy of brightest cluster galaxies and their surroundings MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY Edwards, L. O., Salinas, M., Stanley, S., West, P., Trierweiler, I., Alpert, H., Coelho, P., Koppaka, S., Tremblay, G. R., Martel, H., Li, Y. 2020; 491 (2): 2617–38

  View details for DOI 10.1093/mnras/stz2706

  View details for Web of Science ID 000512302100079

• NONLINEARITY OF DEGENERATELY DOPED FLEXURAL MODE SILICON MICROMECHANICAL RESONATORS Koppaka, S., Alter, A. L., Vukasin, G. D., Shin, D. D., Flader, I. B., Chen, Y., Kenny, T. W., IEEE IEEE. 2019: 1897–1900

  View details for Web of Science ID 000539487000480