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  • Cutting Edge: Engineering Active IKKß in T Cells Drives Tumor Rejection. Journal of immunology Evaristo, C., Spranger, S., Barnes, S. E., Miller, M. L., Molinero, L. L., Locke, F. L., Gajewski, T. F., Alegre, M. 2016; 196 (7): 2933-2938

    Abstract

    Acquired dysfunction of tumor-reactive T cells is one mechanism by which tumors can evade the immune system. Identifying and correcting pathways that contribute to such dysfunction should enable novel anticancer therapy design. During cancer growth, T cells show reduced NF-κB activity, which is required for tumor rejection. Impaired T cell-intrinsic NF-κB may create a vicious cycle conducive to tumor progression and further T cell dysfunction. We hypothesized that forcing T cell-intrinsic NF-κB activation might break this cycle and induce tumor elimination. NF-κB was activated in T cells by inducing the expression of a constitutively active form of the upstream activator IκB kinase β (IKKβ). T cell-restricted constitutively active IKKβ augmented the frequency of functional tumor-specific CD8(+) T cells and improved tumor control. Transfer of constitutively active IKKβ-transduced T cells also boosted endogenous T cell responses that controlled pre-established tumors. Our results demonstrate that driving T cell-intrinsic NF-κB can result in tumor control, thus identifying a pathway with potential clinical applicability.

    View details for DOI 10.4049/jimmunol.1501144

    View details for PubMedID 26903482

    View details for PubMedCentralID PMC4799771

  • T cell-NF-κB activation is required for tumor control in vivo Journal for Immunotherapy of Cancer Barnes, S. E., Wang, Y., Chen, L., Molinero, L. L., Gajewski, T. F., Evaristo, C., Alegre, M. 2015; 3 (1)
  • Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance MEDIATORS OF INFLAMMATION Chng, M. H., Alonso, M. N., Barnes, S. E., Nguyen, K. D., Engleman, E. G. 2015

    View details for DOI 10.1155/2015/593075

    View details for Web of Science ID 000356285300001

    View details for PubMedID 26146464