Bio


I am PhD candidate in Professor Ellen Kuhl's Living Matter Lab. I study how we can leverage physics-informed machine learning to automate the process of determining which models best fit experimental stress-stretch data.

Honors & Awards


  • EDGE-STEM Doctoral Fellowship, Stanford VPGE
  • NSF GRFP, NSF

Education & Certifications


  • M.S., Stanford University, Mechanical Engineering (2022)
  • B.S., Worcester Polytechnic Institute, Biomedical Engineering (2019)

Current Research and Scholarly Interests


biomechanics, machine learning, computational modeling

Lab Affiliations


All Publications


  • Automated model discovery for human brain using Constitutive Artificial Neural Networks Acta Biomaterialia Linka, K., St. Pierre, S. R., Kuhl, E. 2023
  • Sex Matters: A Comprehensive Comparison of Female and Male Hearts. Frontiers in physiology St Pierre, S. R., Peirlinck, M., Kuhl, E. 2022; 13: 831179

    Abstract

    Cardiovascular disease in women remains under-diagnosed and under-treated. Recent studies suggest that this is caused, at least in part, by the lack of sex-specific diagnostic criteria. While it is widely recognized that the female heart is smaller than the male heart, it has long been ignored that it also has a different microstructural architecture. This has severe implications on a multitude of cardiac parameters. Here, we systematically review and compare geometric, functional, and structural parameters of female and male hearts, both in the healthy population and in athletes. Our study finds that, compared to the male heart, the female heart has a larger ejection fraction and beats at a faster rate but generates a smaller cardiac output. It has a lower blood pressure but produces universally larger contractile strains. Critically, allometric scaling, e.g., by lean body mass, reduces but does not completely eliminate the sex differences between female and male hearts. Our results suggest that the sex differences in cardiac form and function are too complex to be ignored: the female heart is not just a small version of the male heart. When using similar diagnostic criteria for female and male hearts, cardiac disease in women is frequently overlooked by routine exams, and it is diagnosed later and with more severe symptoms than in men. Clearly, there is an urgent need to better understand the female heart and design sex-specific diagnostic criteria that will allow us to diagnose cardiac disease in women equally as early, robustly, and reliably as in men.Systematic Review Registration: https://livingmatter.stanford.edu/.

    View details for DOI 10.3389/fphys.2022.831179

    View details for PubMedID 35392369