All Publications

  • Proton mediated control of biochemical reactions with bioelectronic pH modulation. Scientific reports Deng, Y., Miyake, T., Keene, S., Josberger, E. E., Rolandi, M. 2016; 6: 24080-?


    In Nature, protons (H(+)) can mediate metabolic process through enzymatic reactions. Examples include glucose oxidation with glucose dehydrogenase to regulate blood glucose level, alcohol dissolution into carboxylic acid through alcohol dehydrogenase, and voltage-regulated H(+) channels activating bioluminescence in firefly and jellyfish. Artificial devices that control H(+) currents and H(+) concentration (pH) are able to actively influence biochemical processes. Here, we demonstrate a biotransducer that monitors and actively regulates pH-responsive enzymatic reactions by monitoring and controlling the flow of H(+) between PdHx contacts and solution. The present transducer records bistable pH modulation from an "enzymatic flip-flop" circuit that comprises glucose dehydrogenase and alcohol dehydrogenase. The transducer also controls bioluminescence from firefly luciferase by affecting solution pH.

    View details for DOI 10.1038/srep24080

    View details for PubMedID 27052724

  • An enzyme logic bioprotonic transducer APL MATERIALS Miyake, T., Josberger, E. E., Keene, S., Deng, Y., Rolandi, M. 2015; 3 (1)

    View details for DOI 10.1063/1.4900886

    View details for Web of Science ID 000348995000010

  • Taking electrons out of bioelectronics: bioprotonic memories, transistors, and enzyme logic JOURNAL OF MATERIALS CHEMISTRY C Hemmatian, Z., Miyake, T., Deng, Y., Josberger, E. E., Keene, S., Kautz, R., Zhong, C., Jin, J., Rolandi, M. 2015; 3 (25): 6407-6412

    View details for DOI 10.1039/c5tc00502g

    View details for Web of Science ID 000356529100002