Stanford Advisors

Contact

  • Academic
    smodgil@stanford.edu
    University - Scholar Department: Ophthalmology Position: Postdoctoral Scholar
    University - Academic staff Department: Ophthalmology Research/Clinical Trials Position: Basic Life Research Scientist

Additional Info

  • Mail Code: 5353

All Publications

  • Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen AGING AND DISEASE Modgil, S., Ahmed, T., Liao, Y. 2024

    View details for DOI 10.14336/AD.2024.0459

    View details for Web of Science ID 001331951300001

  • High-Phosphate induced Calcium deposits in Optic Nerve following Anterior Ischemic Optic Neuropathy (AION) Modgil, S., Hsu, R., Shariati, A., Liao, Y. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2024

    View details for Web of Science ID 001313316203082

  • Melanopsin: A potential therapeutic target for retinopathy of prematurity Radu, A., Danziger, G. S., Modgil, S., Shah, M., Dumas, C., Zhang, H., Chrenek, M. A., Sellers, J. T., Lang, R. A., Boatright, J. H., Iuvone, P. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2024

    View details for Web of Science ID 001312227701011

  • Perivascular Neurons Instruct Three-Dimensional Retinal Vascular Lattice Formation via Direct Neurovascular Contact Toma, K., Zhao, M., Zhang, S., Modgil, S., Shang, W., Liao, Y., Kim, T., Duan, X. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2024

    View details for Web of Science ID 001313316202343

  • Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact. Cell Toma, K., Zhao, M., Zhang, S., Wang, F., Graham, H. K., Zou, J., Modgil, S., Shang, W. H., Tsai, N. Y., Cai, Z., Liu, L., Hong, G., Kriegstein, A. R., Hu, Y., Körbelin, J., Zhang, R., Liao, Y. J., Kim, T. N., Ye, X., Duan, X. 2024

    Abstract

    The vasculature of the central nervous system is a 3D lattice composed of laminar vascular beds interconnected by penetrating vessels. The mechanisms controlling 3D lattice network formation remain largely unknown. Combining viral labeling, genetic marking, and single-cell profiling in the mouse retina, we discovered a perivascular neuronal subset, annotated as Fam19a4/Nts-positive retinal ganglion cells (Fam19a4/Nts-RGCs), directly contacting the vasculature with perisomatic endfeet. Developmental ablation of Fam19a4/Nts-RGCs led to disoriented growth of penetrating vessels near the ganglion cell layer (GCL), leading to a disorganized 3D vascular lattice. We identified enriched PIEZO2 expression in Fam19a4/Nts-RGCs. Piezo2 loss from all retinal neurons or Fam19a4/Nts-RGCs abolished the direct neurovascular contacts and phenocopied the Fam19a4/Nts-RGC ablation deficits. The defective vascular structure led to reduced capillary perfusion and sensitized the retina to ischemic insults. Furthermore, we uncovered a Piezo2-dependent perivascular granule cell subset for cerebellar vascular patterning, indicating neuronal Piezo2-dependent 3D vascular patterning in the brain.

    View details for DOI 10.1016/j.cell.2024.04.010

    View details for PubMedID 38733989

  • Development of human cellular model for ectopic calcification to study the physiopathological mechanism for Optic Disc Drusen (ODD) Patel, H., Imventarza, J., Kumar, A., Shariati, A., Iweka, C., Swarup, A., Kaushal, K., Modgil, S., Li, S., Nahmou, M., Wu, G., Chiu, W., Liao, Y. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2023

    View details for Web of Science ID 001053795604036

  • Whole genome sequencing to elucidate the molecular pathology of Optic Disc Drusen Kaushal, K., Pugazhendhi, S., Li, Y., Wang, M., Patel, H., Modgil, S., Chen, R., Liao, Y. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2023

    View details for Web of Science ID 001053795605046