Srinidhi Polkampally

All Publications

• Scoping review of deep learning research illuminates artificial intelligence chasm in otolaryngology-head and neck surgery. NPJ digital medicine Liu, G. S., Fereydooni, S., Lee, M. C., Polkampally, S., Huynh, J., Kuchibhotla, S., Shah, M. M., Ayoub, N. F., Capasso, R., Chang, M. T., Doyle, P. C., Holsinger, F. C., Patel, Z. M., Pepper, J. P., Sung, C. K., Creighton, F. X., Blevins, N. H., Stankovic, K. M. 2025; 8 (1): 265

  Abstract

  Clinical validation studies are important to translate artificial intelligence (AI) technology in healthcare but may be underperformed in Otolaryngology - Head & Neck Surgery (OHNS). This scoping review examined deep learning publications in OHNS between 1996 and 2023. Searches on MEDLINE, EMBASE, and Web of Science databases identified 3236 articles of which 444 met inclusion criteria. Publications increased exponentially from 2012-2022 across 48 countries and were most concentrated in otology and neurotology (28%), most targeted extending health care provider capabilities (56%), and most used image input data (55%) and convolutional neural network models (63%). Strikingly, nearly all studies (99.3%) were in silico, proof of concept early-stage studies. Three (0.7%) studies conducted offline validation and zero (0%) clinical validation, illuminating the "AI chasm" in OHNS. Recommendations to cross this chasm include focusing on low complexity and low risk tasks, adhering to reporting guidelines, and prioritizing clinical translation studies.

  View details for DOI 10.1038/s41746-025-01693-0

  View details for PubMedID 40346307

  View details for PubMedCentralID 9391954

• Gamification to enhance clinical and technical skills in surgical residency: A systematic review. American journal of surgery Samadzadeh Tabrizi, N., Lin, N., Polkampally, S., Kuchibhotla, S., Lin, Y. 2025: 116339

  Abstract

  Gamification has emerged as an adjunct to traditional teaching methods, however, literature on its application in surgical education is limited. We sought to explore the prevalence and impact of gamification techniques among surgical trainees.A systematic review was performed to identify studies using gamification in surgical training, where gamification was defined as the use of game elements to foster competition.Surgical residents.Twenty-two studies, including 1283 participants, described the use of gamification in surgical education. Thirteen studies focused on knowledge-based games and ten on technical skills. Gamification was associated with improvements in technical performance, knowledge acquisition, and overall engagement among surgical trainees. Additionally, satisfaction surveys indicated a positive reception of gamification as an educational tool.Gamification presents a promising approach to enhancing the performance of surgical trainees in an engaging learning environment.

  View details for DOI 10.1016/j.amjsurg.2025.116339

  View details for PubMedID 40274424

• The health impacts of political unrest in Bangladesh and steps forward. Medicine, conflict, and survival Polkampally, S., Jain, B., Ahmed, T., Islam, M. T., Bendavid, E. 2025: 1-5

  View details for DOI 10.1080/13623699.2025.2471733

  View details for PubMedID 40038054

• Chirality and asymmetry increase the potency of candidate ADRM1/RPN13 inhibitors. PloS one Anchoori, R. K., George, L., Tseng, S. H., Lam, B., Polkampally, S., Amiano, A. D., Foran, P., Tsingine, H., Samanapally, H., Carrizo Velasquez, F., Das, S., Xing, D., Bin Salam, A., Karanam, B., Hung, C. F., Roden, R. B. 2021; 16 (9): e0256937

  Abstract

  Bortezomib and the other licensed 20S proteasome inhibitors show robust activity against liquid tumors like multiple myeloma, but have disappointed against solid tumors including ovarian cancer. Consequently, interest is mounting in alternative non-peptide based drugs targeting the proteasome's 19S regulatory particle subunit, including its ubiquitin receptor RPN13. RA183 and RA375 are more potent analogs of the prototypic inhibitor of RPN13 (iRPN13) called RA190, and they show promise for the treatment of ovarian cancer. Here we demonstrate that rendering these candidate RPN13 inhibitors chiral and asymmetric through the addition of a single methyl to the core piperidone moiety increases their potency against cancer cell lines, with the S-isomer being more active than the R-isomer. The enhanced cancer cell cytotoxicities of these compounds are associated with improved binding to RPN13 in cell lysates, ATP depletion by inhibition of glycolysis and mitochondrial electron chain transport, mitochondrial depolarization and perinuclear clustering, oxidative stress and glutathione depletion, and rapid accumulation of high molecular weight polyubiquitinated proteins with a consequent unresolved ubiquitin proteasome system (UPS) stress response. Cytotoxicity was associated with an early biomarker of apoptosis, increased surface annexin V binding. As for cisplatin, BRCA2 and ATM deficiency conferred increased sensitivity to these iRPN13s. Ubiquitination plays an important role in coordinating DNA damage repair and the iRPN13s may compromise this process by depletion of monomeric ubiquitin following its sequestration in high molecular weight polyubiquitinated protein aggregates. Indeed, a synergistic cytotoxic response was evident upon treatment of several ovarian cancer cell lines with either cisplatin or doxorubicin and our new candidate iRPN13s, suggesting that such a combination approach warrants further exploration for the treatment of ovarian cancer.

  View details for DOI 10.1371/journal.pone.0256937

  View details for PubMedID 34506530

  View details for PubMedCentralID PMC8432795