Honors & Awards
Ramsay Fellowship in Pediatric Translational Medicine, Stanford University (2014-2015)
Alan M. Krensky Endowed Clinical Fellowship, Stanford University (2013-2014)
Friends of the Children Fund Scholarship, American Academy of Pediatrics (2013)
James K. Lace Advocacy Award, Oregon Pediatric Society (2013)
Delta Omega National Honors Society for Public Health, UNC Gillings School of Global Public Health (2009)
Heusner Pupil Award, UNC School of Medicine (2008)
John D. Idol Memorial Scholarship, UNC School of Medicine (2006-2010)
Pat and Katherine Brown Medical Scholarship, UNC School of Medicine (2005-2006)
National Merit Scholarship, Stanford University (2000)
Doctor of Medicine, University of North Carolina, Chapel Hill (2010)
Master of Public Health, University of North Carolina, Chapel Hill (2009)
Bachelor of Science, Stanford University, BIOL-BS (2004)
Tandy Aye, Postdoctoral Faculty Sponsor
Current Research and Scholarly Interests
Dr. Crossen’s research focuses on identifying patterns in ambulatory care that are associated with recurrent diabetic ketoacidosis (DKA) among pediatric patients with type 1 diabetes. Dr. Crossen is collaborating with colleagues at Stanford’s Center for Policy, Outcomes, and Prevention (CPOP) and using data from the California Children’s Services (CCS) program. She hopes to design and pilot case-management strategies for DKA prevention in the future based on results of this research.
Current opinion in obstetrics & gynecology
2014; 26 (5): 332-338
Precocious puberty continues to elicit great interest and concern among medical practitioners, as well as the public.Studies have elucidated neural regulation of puberty by kisspeptin, neurokinin B, and other factors. Cohort studies from the North America and Europe suggest that the age of thelarche may be earlier than determined 2 decades ago, and menarche may be slightly earlier, but the causes are unclear. Long-term outcomes of gonadotropin-releasing hormone analog therapy demonstrate increases in final height in the youngest treated patients, with no apparent adverse bone or reproductive consequences.Although the appropriate threshold age of onset of central puberty remains uncertain, gonadotropin-releasing hormone analog therapy is well tolerated and effective in suppressing luteinizing hormone pulses and ovarian activity.
View details for DOI 10.1097/GCO.0000000000000099
View details for PubMedID 25144596
- Visual Diagnosis: Premature baby girl with ambiguous genitalia NeoReviews 2013; 14 (7)
Mood and neuropsychological changes in women with midlife depression treated with escitalopram
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
2006; 26 (4): 361-366
This study assessed mood and neuropsychological function in a population of middle-aged women with major depressive disorder treated with escitalopram.Psychometric data measuring severity of depression were collected from 19 women and neuropsychological data were collected from 17 women aged between 45 and 65 years with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis of major depression in a study in the Behavioral Neuroendocrinology Program at the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine. All women were treated with escitalopram in an open-label design. Mean age was 55.94 years and mean number of years of education was 16.36 years. Diagnosis of major depressive disorder was assessed with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and mood was evaluated with the 21-item Hamilton Depression Rating Scale (HAM-D) at baseline and at weekly follow-ups for 12 weeks. Cognition was assessed at baseline and 3 months after treatment using a neuropsychological test battery, which included an abbreviated measure of Full Scale Intelligence Quotient, measures of attention and processing speed, verbal and nonverbal memory, executive functioning, and verbal fluency. Self-report data were collected on current menopause status and current hormone therapy use in the postmenopausal women. Paired sample t tests were used to analyze the change in total HAM-D scores and neuropsychological variables.Statistically significant improvements were found in total HAM-D score, Wechsler Memory Scale III Logical Memory 1st Recall, I, and II scores, Wechsler Memory Scale III Visual Reproduction I scores, and Trail Making Test Part B scores. There was a statistically significant decrease in Controlled Oral Word Association Test FAS scores.Treatment of depression with escitalopram in a population of middle-aged women was shown to improve mood and cognitive efficiency in complex attention, short- and long-term recall of contextual information, short-term recall of visual information, and cognitive flexibility; however, it was shown to worsen phonemic fluency.
View details for DOI 10.1097/01.jcp.0000227699.26375.f8
View details for Web of Science ID 000239551200003
View details for PubMedID 16855452
Reelin, integrin and Dab1 interactions during embryonic cerebral cortical development
2005; 15 (10): 1632-1636
Extracellular matrix-like molecule reelin and cell surface adhesion receptors such as alpha3beta1 integrin can regulate neuronal migration and position in the developing cerebral cortex. Here we show that alpha3beta1 integrin binds to the N-terminal region of reelin, a site distinct from the region of reelin shown to associate with other reelin receptors such as VLDLR/ApoER2. Furthermore, Dab1, a member of the reelin signaling pathway, can complex with the cytoplasmic region of beta1 integrin in a reelin-dependent manner. Thus, alpha3beta1 integrin-reelin interactions may contribute to appropriate neuronal placement in the developing cerebral cortex.
View details for DOI 10.1093/cercor/bhi041
View details for Web of Science ID 000231921600015
View details for PubMedID 15703255
Perimenopausal mental disorders: Epidemiology and phenomenology
2005; 10 (6): 471-478
Perimenopause, the interval of irregular menstrual activity which directly precedes menopause, is characterized by widely fluctuating hormone levels amidst a large-scale decline in circulating estrogen. This phase in a woman's life is typically accompanied by physical discomforts including vasomotor symptoms, such as headaches, insomnia, and hot flushes, as well as genital atrophy. Not surprisingly, studies suggest a significant increase in mood lability for women during this time. While some evidence points toward an exacerbation of bipolar mood symptoms and an increase in schizophrenic psychosis during perimenopause, the majority of research conducted on perimenopausal mental disorders has focused on unipolar depression. Studies vary widely in methodology, definitions of menopausal status, and degrees of depression among subjects; however, the majority of findings indicate an increased susceptibility to depression during the perimenopausal transition. This greater susceptibility may be due to neuroendocrine effects of declining estrogen levels, the subjective experience of somatic symptoms resulting from this hormonal decline, and/or the more frequent occurrence of "exit" or "loss" events for women during this stage of life. At this time, more research is needed to address questions of prevalence, risk, and etiology for depression and other major mental disorders as related to the physiological and psychosocial changes associated with perimenopause.
View details for Web of Science ID 000230160000012
View details for PubMedID 15908901
alpha 3 beta 1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development
2004; 131 (24): 6023-6031
We show that alpha3 integrin mutation disrupts distinct aspects of neuronal migration and placement in the cerebral cortex. The preplate develops normally in alpha3 integrin mutant mice. However, time lapse imaging of migrating neurons in embryonic cortical slices indicates retarded radial and tangential migration of neurons, but not ventricular zone-directed migration. Examination of the actin cytoskeleton of alpha3 integrin mutant cortical cells reveals aberrant actin cytoskeletal dynamics at the leading edges. Deficits are also evident in the ability of developing neurons to probe their cellular environment with filopodial and lamellipodial activity. Calbindin or calretinin positive upper layer neurons as well as the deep layer neurons of alpha3 integrin mutant mice expressing EGFP were misplaced. These results suggest that alpha3beta1 integrin deficiency impairs distinct patterns of neuronal migration and placement through dysregulated actin dynamics and defective ability to search and respond to migration modulating cues in the developing cortex.
View details for DOI 10.1242/dev.01532
View details for Web of Science ID 000226324200002
View details for PubMedID 15537685