Bio


Tuuli Hietamies, PhD, is a postdoctoral researcher at the Department of Anaesthesiology, Perioperative and Pain Medicine. Her research interests include studying psychedelics and utilising these in the context of brain injury and rehabilitation.

Stanford Advisors


Lab Affiliations


All Publications


  • Diagnostic test accuracy of remote, multidomain cognitive assessment (telephone and video call) for dementia. The Cochrane database of systematic reviews Beishon, L. C., Elliott, E., Hietamies, T. M., Mc Ardle, R., O'Mahony, A., Elliott, A. R., Quinn, T. J. 2022; 4: CD013724

    Abstract

    Remote cognitive assessments are increasingly needed to assist in the detection of cognitive disorders, but the diagnostic accuracy of telephone- and video-based cognitive screening remains unclear.To assess the test accuracy of any multidomain cognitive test delivered remotely for the diagnosis of any form of dementia. To assess for potential differences in cognitive test scoring when using a remote platform, and where a remote screener was compared to the equivalent face-to-face test.We searched ALOIS, the Cochrane Dementia and Cognitive Improvement Group Specialized Register, CENTRAL, MEDLINE, Embase, PsycINFO, CINAHL, Web of Science, LILACS, and ClinicalTrials.gov (www.gov/) databases on 2 June 2021. We performed forward and backward searching of included citations.We included cross-sectional studies, where a remote, multidomain assessment was administered alongside a clinical diagnosis of dementia or equivalent face-to-face test.Two review authors independently assessed risk of bias and extracted data; a third review author moderated disagreements. Our primary analysis was the accuracy of remote assessments against a clinical diagnosis of dementia. Where data were available, we reported test accuracy as sensitivity and specificity. We did not perform quantitative meta-analysis as there were too few studies at individual test level. For those studies comparing remote versus in-person use of an equivalent screening test, if data allowed, we described correlations, reliability, differences in scores and the proportion classified as having cognitive impairment for each test.The review contains 31 studies (19 differing tests, 3075 participants), of which seven studies (six telephone, one video call, 756 participants) were relevant to our primary objective of describing test accuracy against a clinical diagnosis of dementia. All studies were at unclear or high risk of bias in at least one domain, but were low risk in applicability to the review question. Overall, sensitivity of remote tools varied with values between 26% and 100%, and specificity between 65% and 100%, with no clearly superior test. Across the 24 papers comparing equivalent remote and in-person tests (14 telephone, 10 video call), agreement between tests was good, but rarely perfect (correlation coefficient range: 0.48 to 0.98).Despite the common and increasing use of remote cognitive assessment, supporting evidence on test accuracy is limited. Available data do not allow us to suggest a preferred test. Remote testing is complex, and this is reflected in the heterogeneity seen in tests used, their application, and their analysis. More research is needed to describe accuracy of contemporary approaches to remote cognitive assessment. While data comparing remote and in-person use of a test were reassuring, thresholds and scoring rules derived from in-person testing may not be applicable when the equivalent test is adapted for remote use.

    View details for DOI 10.1002/14651858.CD013724.pub2

    View details for PubMedID 35395108

  • Brain wide mapping of neuronal activity evoked by MDMA, a rapid-acting therapy for post-traumatic stress disorder Ryskamp, D., Llorach, P., Schlozman, S., Rastegar, Z., Salgado, J. S., Hietamies, T., Barbosa, D. A., Pinto, D., Neuman, P., Hell, M., Beier, K., Malenka, R. C., Heifets, B. D. LIPPINCOTT WILLIAMS & WILKINS. 2021: 583-584
  • Brain-wide unbiased mapping of neuronal activity pinpoints ketamine's interaction with the opioid system in mice Ryskamp, D., Hietamies, T., Schlozman, S., Llorach, P., Salgado, J. S., Barbosa, D. A., Heifets, B. D. LIPPINCOTT WILLIAMS & WILKINS. 2021: 582
  • UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., Allan, S. M., Bath, P. M., Brezzo, G., Carare, R. O., Carswell, H., Clarkson, A. N., Currie, G., Farr, T. D., Fowler, J. H., Good, M., Hainsworth, A. H., Hall, C., Horsburgh, K., Kalaria, R., Kehoe, P., Lawrence, C., Macleod, M., McColl, B. W., McNeilly, A., Miller, A. A., Miners, S., Mok, V., O'Sullivan, M., Platt, B., Sena, E. S., Sharp, M., Strangeward, P., Szymkowiak, S., Touyz, R. M., Trueman, R. C., White, C., McCabe, C., Work, L. M., Quinn, T. J. 2020; 40 (7): 1402–14

    Abstract

    Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and what could be implemented to overcome identified challenges. Twelve UK VCI research centres were identified and invited to complete a questionnaire and attend a one-day workshop. Questionnaire responses demonstrated agreement that outcome assessments in VCI preclinical research vary by group and even those common across groups, may be performed differently. From the workshop, six themes were discussed: issues with preclinical models, reasons for choosing functional assessments, issues in interpretation of functional assessments, describing and reporting functional outcome assessments, sharing resources and expertise, and standardization of outcomes. Eight consensus points emerged demonstrating broadly that the chosen assessment should reflect the deficit being measured, and therefore that one assessment does not suit all models; guidance/standardisation on recording VCI outcome reporting is needed and that uniformity would be aided by a platform to share expertise, material, protocols and procedures thus reducing heterogeneity and so increasing potential for collaboration, comparison and replication. As a result of the workshop, UK wide consensus statements were agreed and future priorities for preclinical research identified.

    View details for DOI 10.1177/0271678X20910552

    View details for Web of Science ID 000523805200001

    View details for PubMedID 32151228

    View details for PubMedCentralID PMC7307003

  • Variability of functional outcome measures used in animal models of stroke and vascular cognitive impairment - a review of contemporary studies JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM Hietamies, T. M., Ostrowski, C., Pei, Z., Feng, L., McCabe, C., Work, L. M., Quinn, T. J. 2018; 38 (11): 1872–84

    Abstract

    Despite promising preclinical data, few novel stroke therapies have shown efficacy in man. Efforts to improve standards in conduct and reporting of preclinical research are ongoing. In clinical trials, inconsistency in outcome measures led to regulatory agencies and funders mandating use of a core set of functional outcomes. Our aim was to describe functional outcome measures in preclinical stroke and vascular cognitive impairment (VCI) studies. From 14 high impact journals (January 2005-December 2015 inclusive), 91,956 papers were screened with 1302 full texts analyzed for stroke (ischemic and hemorrhagic) and 56 for VCI studies. In total, 636 (49%) stroke and 37 (66%) VCI papers reported functional outcome measures. There were 74 different functional assessments reported in stroke and 20 in VCI studies. Neurological deficit scores (74%) and Morris water maze (60%) were most commonly used in stroke and VCI, respectively. However, inconsistencies in methods used to assess and score recovery were noted. Neurological and behavioural functional outcome measures are increasingly used in preclinical stroke or VCI studies; however, there is substantial variation in methods. A strict standardized outcome set may not be suitable for translational work, but greater consistency in choice, application and reporting of outcomes may improve the science.

    View details for DOI 10.1177/0271678X18799858

    View details for Web of Science ID 000450149200002

    View details for PubMedID 30203705

    View details for PubMedCentralID PMC6259321