Characterization of comorbidity heterogeneity among 13,667 patients with hidradenitis suppurativa.
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disorder characterized by recurrent abscesses in the groin and flexural areas. HS is associated with a wide range of comorbidities that complicate the disease course. Although these comorbidities have been well-described, it remains unclear how these comorbidities co-associate and whether comorbidity profiles affect disease trajectory. In addition, it is unknown how comorbidity associations are modulated by race and gender. In this comprehensive analysis of 77 million patients in a large U.S. population-based cohort, we examine co-association patterns among HS comorbidities and identify clinically relevant phenotypic subtypes within HS. We demonstrate that these subtypes not only differ among races, but also influence clinical outcomes as measured by HS-related emergency department (ED) visits and cellulitis. Taken together, our findings provide key insights that elucidate the unique disease trajectories experienced by HS patients, and equip clinicians with a novel framework for risk stratification and improved targeted care in HS.
View details for DOI 10.1172/jci.insight.151872
View details for PubMedID 34546979
- Hyperhidrosis affects quality of life in hidradenitis suppurativa: a prospective analysis. Journal of the American Academy of Dermatology 2019
- Complete remission from intralesional talimogene laherparepvec for regionally advanced Merkel cell carcinoma in an immunocompromised solid organ transplant patient. JAAD case reports 2021; 13: 144-146
Journal attitudes and outcomes of preprints in dermatology.
The British journal of dermatology
The use of preprints, manuscripts that can be uploaded to a public server and made almost immediately available for public dissemination without peer review, is becoming increasingly common.1 Preprint servers are not typically associated with established peer-reviewed journals and often operate independently. Proponents of preprints point toward improved rapid dissemination of results and opportunities for crowdsourced feedback before submission to peer-reviewed journals.1 Conversely, inconsistent upload criteria among preprint servers (such as lack of guidance for reporting conflict of interest or image manipulation),1 and the risk for widespread discourse of non-peer reviewed results by news media may impinge on research integrity.2 As members of the public may not understand the difference between preprints and traditionally peer-reviewed articles, preprints have the potential to cause widespread confusion and mistrust.2 Use of preprints may also make publication of results in traditional journals more difficult, as the results may be perceived to be less novel. Despite controversy, the number of preprints continue to rise.3 There is limited understanding of how dermatology journals view and consider preprints. In this study, we explore dermatology journal policies toward the submission of preprint articles for publication, and corresponding publication outcomes of dermatology articles previously uploaded to a large clinically oriented preprint server.
View details for DOI 10.1111/bjd.20065
View details for PubMedID 33742455
Gaps in Treatment and Surveillance: Head and Neck Cancer Care in a Safety-Net Hospital.
2020; 4 (1): 2473974X19900761
Treatment delays and suboptimal adherence to posttreatment surveillance may adversely affect head and neck cancer (HNC) outcomes. Such challenges can be exacerbated in safety-net settings that struggle with limited resources and serve a disproportionate number of patients vulnerable to gaps in care. This study aims to characterize treatment delays and adherence with posttreatment surveillance in HNC care at an urban tertiary care public hospital in San Francisco.Retrospective chart review.Urban tertiary care public hospital in San Francisco.We identified all cases of HNC diagnosed from 2008 to 2010 through the electronic medical record. We abstracted data, including patient characteristics, disease characteristics, pathology and radiology findings, treatment details, posttreatment follow-up, and clinical outcomes.We included 64 patients. Median time from diagnosis to treatment initiation (DTI) was 57 days for all patients, 54 days for patients undergoing surgery only, 49 days for patients undergoing surgery followed by adjuvant radiation ± chemotherapy, 65 days for patients undergoing definitive radiation ± chemotherapy, and 29 days for patients undergoing neoadjuvant chemotherapy followed by radiation or chemoradiation. Overall, 69% of patients completed recommended treatment. Forty-two of 61 (69%) patients demonstrated adherence to posttreatment visits in year 1; this fell to 14 out of 30 patients (47%) by year 5.DTI was persistently prolonged in this study compared with prior studies in other public hospital settings. Adherence to posttreatment surveillance was suboptimal and continued to decline as the surveillance period progressed.
View details for DOI 10.1177/2473974X19900761
View details for PubMedID 32083239
View details for PubMedCentralID PMC7005972
Multisensory Logic of Infant-Directed Aggression by Males
2018; 175 (7): 1827-+
Newborn mice emit signals that promote parenting from mothers and fathers but trigger aggressive responses from virgin males. Although pup-directed attacks by males require vomeronasal function, the specific infant cues that elicit this behavior are unknown. We developed a behavioral paradigm based on reconstituted pup cues and showed that discrete infant morphological features combined with salivary chemosignals elicit robust male aggression. Seven vomeronasal receptors were identified based on infant-mediated activity, and the involvement of two receptors, Vmn2r65 and Vmn2r88, in infant-directed aggression was demonstrated by genetic deletion. Using the activation of these receptors as readouts for biochemical fractionation, we isolated two pheromonal compounds, the submandibular gland protein C and hemoglobins. Unexpectedly, none of the identified vomeronasal receptors and associated cues were specific to pups. Thus, infant-mediated aggression by virgin males relies on the recognition of pup's physical traits in addition to parental and infant chemical cues.
View details for DOI 10.1016/j.cell.2018.11.032
View details for Web of Science ID 000453242200013
View details for PubMedID 30550786
View details for PubMedCentralID PMC6558521