Honors & Awards
First Place in the CTVIE19 Grand Challenge, The American Association of Physicists in Medicine (2019)
Ballard Seashore Dissertation Fellowship, University of Iowa (2019)
China National Scholarship (acceptance rate 0.2%), Ministry of Education of the People’s Republic of China (2012)
First Prize, Jiangsu Province Undergraduate Electronic Design Contest (TI Cup), Jiangsu Provincial Department of Education, Jiangsu Province, China (2012)
First Prize, Jiangsu Province Undergraduate Mathematics Contest, Jiangsu Provincial Department of Education, Jiangsu Province, China (2012)
First Prize, National Senior High School Mathematics Contest (acceptance rate 0.04%), Jiangsu Mathematical Society, Jiangsu Province, China (2009)
Doctor of Philosophy, University of Iowa, Electrical and Computer Engineering (2019)
Master of Science, University of Iowa, Mathematics (2018)
Master of Science, University of Iowa, Electrical and Computer Engineering (2016)
Bachelor of Engineering, Soochow University, Electronics and Information Engineering (2014)
Mirabela Rusu, Postdoctoral Faculty Sponsor
Registration of pre-surgical MRI and histopathology images from radical prostatectomy via RAPSODI.
PURPOSE: Magnetic resonance imaging (MRI) has great potential to improve prostate cancer diagnosis, however, subtle differences between cancer and confounding conditions render prostate MRI interpretation challenging. The tissue collected from patients who undergo radical prostatectomy provides a unique opportunity to correlate histopathology images of the prostate with pre-operative MRI to accurately map the extent of cancer from histopathology images onto MRI. We seek to develop an open-source, easy-to-use platform to align pre-surgical MRI and histopathology images of resected prostates in patients who underwent radical prostatectomy to create accurate cancer labels on MRI.METHODS: Here, we introduce RAdiology Pathology Spatial Open-Source multi-Dimensional Integration (RAPSODI), the first open-source framework for the registration of radiology and pathology images. RAPSODI relies on three steps. First, it creates a 3D reconstruction of the histopathology specimen as a digital representation of the tissue before gross sectioning. Second, RAPSODI registers corresponding histopathology and MRI slices. Third, the optimized transforms are applied to the cancer regions outlined on the histopathology images to project those labels onto the pre-operative MRI.RESULTS: We tested RAPSODI in a phantom study where we simulated various conditions, e.g., tissue shrinkage during fixation. Our experiments showed that RAPSODI can reliably correct multiple artifacts. We also evaluated RAPSODI in 157 patients from three institutions that underwent radical prostatectomy and have very different pathology processing and scanning. RAPSODI was evaluated in 907 corresponding histpathology-MRI slices and achieved a Dice coefficient of 0.97±0.01 for the prostate, a Hausdorff distance of 1.99±0.70 mm for the prostate boundary, a urethra deviation of 3.09±1.45 mm, and a landmark deviation of 2.80±0.59 mm between registered histopathology images and MRI.CONCLUSION: Our robust framework successfully mapped the extent of cancer from histopathology slices onto MRI providing labels from training machine learning methods to detect cancer on MRI.
View details for DOI 10.1002/mp.14337
View details for PubMedID 32564359
Modeling the impact of out-of-phase ventilation on normal lung tissue response to radiation dose
To create a dose-response model that predicts lung ventilation change following radiation therapy, and examine the effects of out-of-phase ventilation.The dose-response model was built using 27 human subjects who underwent radiation therapy (RT) from an IRB-approved trial. For each four-dimensional computed tomography, two ventilation maps were created by calculating the N-phase local expansion ratio (LERN ) using most or all breathing phases and the 2-phase LER (LER2 ) using only the end inspiration and end expiration breathing phases. A polynomial regression model was created using the LERN ventilation maps pre-RT and post-RT and dose distributions for each subject, and crossvalidated with a leave-one-out method. Further validation of the model was performed using 15 additional human subjects using common statistical operating characteristics and gamma pass rates.For voxels receiving 20 Gy or greater, there was a significant increase from 52% to 59% (P = 0.03) in the gamma pass rates of the LERN model predicted post-RT Jacobian maps to the actual post-RT Jacobian maps, relative to the LER2 model. Additionally, accuracy significantly increased (P = 0.03) from 68% to 75% using the LERN model, relative to the LER2 model.The LERN model was significantly more accurate than the LER2 model at predicting post-RT ventilation maps. More accurate post-RT ventilation maps will aid in producing a higher quality functional avoidance treatment plan, allowing for potentially better normal tissue sparing.
View details for DOI 10.1002/mp.14146
View details for Web of Science ID 000526995800001
View details for PubMedID 32187683
Quantifying Regional Lung Deformation Using Four-Dimensional Computed Tomography: A Comparison of Conventional and Oscillatory Ventilation
FRONTIERS IN PHYSIOLOGY
2020; 11: 14
Mechanical ventilation strategies that reduce the heterogeneity of regional lung stress and strain may reduce the risk of ventilator-induced lung injury (VILI). In this study, we used registration of four-dimensional computed tomographic (4DCT) images to assess regional lung aeration and deformation in 10 pigs under baseline conditions and following acute lung injury induced with oleic acid. CT images were obtained via dynamic axial imaging (Siemens SOMATOM Force) during conventional pressure-controlled mechanical ventilation (CMV), as well as high-frequency and multi-frequency oscillatory ventilation modalities (HFOV and MFOV, respectively). Our results demonstrate that oscillatory modalities reduce intratidal strain throughout the lung in comparison to conventional ventilation, as well as the spatial gradients of dynamic strain along the dorsal-ventral axis. Harmonic distortion of parenchymal deformation was observed during HFOV with a single discrete sinusoid delivered at the airway opening, suggesting inherent mechanical nonlinearity of the lung tissues. MFOV may therefore provide improved lung-protective ventilation by reducing strain magnitudes and spatial gradients of strain compared to either CMV or HFOV.
View details for DOI 10.3389/fphys.2020.00014
View details for Web of Science ID 000518925200001
View details for PubMedID 32153417
View details for PubMedCentralID PMC7044245
N-Phase Local Expansion Ratio for Characterizing Out-of-Phase Lung Ventilation.
IEEE transactions on medical imaging
2020; 39 (6): 2025–34
Out-of-phase ventilation occurs when local regions of the lung reach their maximum or minimum volumes at breathing phases other than the global end inhalation or exhalation phases. This paper presents the N-phase local expansion ratio (LER N ) as a surrogate for lung ventilation. A common approach to estimate lung ventilation is to use image registration to align the end exhalation and inhalation 3DCT images and then analyze the resulting correspondence map. This 2-phase local expansion ratio (LER2) is limited because it ignores out-of-phase ventilation and thus may underestimate local lung ventilation. To overcome this limitation, LER N measures the maximum ratio of local expansion and contraction over the entire breathing cycle. Comparing LER2 to LER N provides a means for detecting and characterizing locations of the lung that experience out-of-phase ventilation. We present a novel in-phase/out-of-phase ventilation (IOV) function plot to visualize and measure the amount of high-function IOV that occurs during a breathing cycle. Treatment planning 4DCT scans collected during coached breathing from 32 human subjects with lung cancer were analyzed in this study. Results show that out-of-phase breathing occurred in all subjects and that the spatial distribution of out-of-phase ventilation varied from subject to subject. For the 32 subjects analyzed, 50% of the out-of-phase regions on average were mislabeled as low-function by LER2 (high-function threshold of 1.1, IOV threshold of 1.05). 4DCT and Xenon-enhanced CT of four sheep showed that LER8 is more accurate than LER2 for measuring lung ventilation.
View details for DOI 10.1109/TMI.2019.2963083
View details for PubMedID 31899418
Radiation Dose Response Model for Ventilation Change Using All Phases of 4DCT
WILEY. 2019: E352
View details for Web of Science ID 000471277702234
Improving the Accuracy of 4DCT-Based Ventilation Measurements Using Multiple Phases
WILEY. 2019: E378
View details for Web of Science ID 000471277702330
Longitudinal Changes in Lung Tissue Elasticity Following Radiation Therapy
WILEY. 2019: E378
View details for Web of Science ID 000471277702331
- Deep Neural Networks and Kernel Density Estimation for Detecting Human Activity Patterns from Geo-Tagged Images: A Case Study of Birdwatching on Flickr ISPRS INTERNATIONAL JOURNAL OF GEO-INFORMATION 2019; 8 (1)
Multi-Frequency Oscillatory Ventilation Minimizes Spatial Gradients of Regional Strain Using 4D CT Image Registration in Porcine Lung Injury
AMER THORACIC SOC. 2019
View details for Web of Science ID 000466776705159
- Nondestructive Measurement of Conformal Coating Thickness on Printed Circuit Board With Ultra-High Resolution Optical Coherence Tomography IEEE ACCESS 2019; 7: 18138–45
Quantifying ventilation change due to radiation therapy using 4DCT Jacobian calculations
2018; 45 (10): 4483–92
Regional ventilation and its response to radiation dose can be estimated using four-dimensional computed tomography (4DCT) and image registration. This study investigated the impact of radiation therapy (RT) on ventilation and the dependence of radiation-induced ventilation change on pre-RT ventilation derived from 4DCT.Three 4DCT scans were acquired from each of 12 subjects: two scans before RT and one scan 3 months after RT. The 4DCT datasets were used to generate the pre-RT and post-RT ventilation maps by registering the inhale phase image to the exhale phase image and computing the Jacobian determinant of the resulting transformation. The ventilation change between pre-RT and post-RT was calculated by taking a ratio of the post-RT Jacobian map to the pre-RT Jacobian map. The voxel-wise ventilation change between pre- and post-RT was investigated as a function of dose and pre-RT ventilation.Lung regions receiving over 20 Gy exhibited a significant decrease in function (3.3%, P < 0.01) compared to those receiving less than 20 Gy. When the voxels were stratified into high and low pre-RT function by thresholding the Jacobian map at 10% volume expansion (Jacobian = 1.1), high-function voxels exhibited 4.8% reduction in function for voxels receiving over 20 Gy, a significantly greater decline (P = 0.037) than the 2.4% reduction in function for low-function voxels. Ventilation decreased linearly with dose in both high-function and low-function regions. High-function regions showed a significantly larger decline in ventilation (P ≪ 0.001) as dose increased (1.4% ventilation reduction/10 Gy) compared to low-function regions (0.3% ventilation reduction/10 Gy). With further stratification of pre-RT ventilation, voxels exhibited increasing dose-dependent ventilation reduction with increasing pre-RT ventilation, with the largest pre-RT Jacobian bin (pre-RT Jacobian between 1.5 and 1.6) exhibiting a ventilation reduction of 4.8% per 10 Gy.Significant ventilation reductions were measured after radiation therapy treatments, and were dependent on the dose delivered to the tissue and the pre-RT ventilation of the tissue. For a fixed radiation dose, lung tissue with high pre-RT ventilation experienced larger decreases in post-RT ventilation than lung tissue with low pre-RT ventilation.
View details for DOI 10.1002/mp.13105
View details for Web of Science ID 000446995000031
View details for PubMedID 30047588
View details for PubMedCentralID PMC6220845
- Sensitivity analysis of Jacobian determinant used in treatment planning for lung cancer SPIE-INT SOC OPTICAL ENGINEERING. 2018
- Population Shape Collapse in Large Deformation Registration of MR Brain Images IEEE. 2016: 549–57