Honors & Awards


  • Dean’s postdoctoral fellowships, Stanford University (07.2013-Present)

Professional Education


  • Doctor of Philosophy, Fudan University (2012)

Stanford Advisors


  • Fan Yang, Postdoctoral Faculty Sponsor

Journal Articles


  • Mutant MCP-1 protein delivery from layer-by-layer coatings on orthopedic implants to modulate inflammatory response. Biomaterials Keeney, M., Waters, H., Barcay, K., Jiang, X., Yao, Z., Pajarinen, J., Egashira, K., Goodman, S. B., Yang, F. 2013; 34 (38): 10287-10295

    Abstract

    Total joint replacement (TJR) is a common and effective surgical procedure for hip or knee joint reconstruction. However, the production of wear particles is inevitable for all TJRs, which activates macrophages and initiates an inflammatory cascade often resulting in bone loss, prosthetic loosening and eventual TJR failure. Macrophage Chemoattractant Protein-1 (MCP-1) is one of the most potent cytokines responsible for macrophage cell recruitment, and previous studies suggest that mutant MCP-1 proteins such as 7ND may be used as a decoy drug to block the receptor and reduce inflammatory cell recruitment. Here we report the development of a biodegradable, layer-by-layer (LBL) coating platform that allows efficient loading and controlled release of 7ND proteins from the surface of orthopedic implants using as few as 14 layers. Scanning electron microscopy and fluorescence imaging confirmed effective coating using the LBL procedure on titanium rods. 7ND protein loading concentration and release kinetics can be modulated by varying the polyelectrolytes of choice, the polymer chemistry, the pH of the polyelectrolyte solution, and the degradation rate of the LBL assembly. The released 7ND from LBL coating retained its bioactivity and effectively reduced macrophage migration towards MCP-1. Finally, the LBL coating remained intact following a femoral rod implantation procedure as determined by immunostaining of the 7ND coating. The LBL platform reported herein may be applied for in situ controlled release of 7ND protein from orthopedic implants, to reduce wear particle-induced inflammatory responses in an effort to prolong the lifetime of implants.

    View details for DOI 10.1016/j.biomaterials.2013.09.028

    View details for PubMedID 24075408

  • Solid tumor penetration by integrin-mediated pegylated poly(trimethylene carbonate) nanoparticles loaded with pactlitaxel Biomaterials Xinyi Jiang, Hongliang Xin, Jijin Gu, Ximing Xu, Weiyi Xia, Shuo Chen, Yike Xie, Liangcen Chen, Yanzuo Chen, Xianyi Sha, Xiaoling Fang 2013
  • Self-aggregated pegylated poly (trimethylene carbonate) nanoparticles decorated with c(RGDyK) peptide for targeted paclitaxel delivery to integrin-rich tumors Biomaterials Xinyi Jiang, Xianyi Sha, Hongliang Xin, Liangcen Chen, Xihui Gao, Xiao Wang, Kitki Law, Jijin Gu, Yanzuo Chen, Ye Jiang, Xiaoqing Ren, Qiuyue Ren, Xiaoling Fang 2011