Yimiao Qu
Postdoctoral Scholar, Stem Cell Biology and Regenerative Medicine
Professional Education
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Master of Science, Peking University (2012)
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Doctor of Science, Peking University (2019)
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Bachelor of Science, Shandong University (2009)
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Doctor of Science, Peking University, China, Integrated Life Sciences (Physics) (2019)
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Master of Science, Peking University, China, Biomedical Engineering (2012)
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Bachelor of Science, Shandong University, China, Biotechnology and Microbiology (2009)
All Publications
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Reshaping Waddington's developmental landscape.
Nature reviews. Genetics
2024
View details for DOI 10.1038/s41576-024-00777-z
View details for PubMedID 39289551
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Whi5 is diluted and protein synthesis does not dramatically increase in pre-Start G1.
Molecular biology of the cell
2022; 33 (5): lt1
View details for DOI 10.1091/mbc.E21-01-0029
View details for PubMedID 35482510
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Protocol for Titrating Gene Expression Levels in Budding Yeast
STAR Protocols
2020; 1 (2): 100082
View details for DOI 10.1016/j.xpro.2020.100082
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Cell Cycle Inhibitor Whi5 Records Environmental Information to Coordinate Growth and Division in Yeast
CELL REPORTS
2019; 29 (4): 987-+
Abstract
Proliferating cells need to evaluate the environment to determine the optimal timing for cell cycle entry. However, how this is achieved is not well understood. Here, we show that, in budding yeast, the G1 inhibitor Whi5 is a key environmental indicator and plays a crucial role in coordinating cell growth and division. We found that, under a variety of nutrient and stress conditions, Whi5 amount in G1 is proportional to the cell's doubling time in the environment, which in turn influences the timing for the next cell cycle entry. In addition, the coordination between division and environment is further fine-tuned in G1 by environmentally dependent growth rate, G1 cyclin-Cdk1 contribution, and Whi5 threshold at the start. Our results show that the cell stores the past environmental information in Whi5, which works together with other mechanisms sensing the current environmental condition to achieve an adaptive cellular decision making process.
View details for DOI 10.1016/j.celrep.2019.09.030
View details for Web of Science ID 000491881400016
View details for PubMedID 31644918
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Reliable cell cycle commitment in budding yeast is ensured by signal integration
ELIFE
2015; 4
Abstract
Cell fate decisions are critical for life, yet little is known about how their reliability is achieved when signals are noisy and fluctuating with time. In this study, we show that in budding yeast, the decision of cell cycle commitment (Start) is determined by the time integration of its triggering signal Cln3. We further identify the Start repressor, Whi5, as the integrator. The instantaneous kinase activity of Cln3-Cdk1 is recorded over time on the phosphorylated Whi5, and the decision is made only when phosphorylated Whi5 reaches a threshold. Cells adjust the threshold by modulating Whi5 concentration in different nutrient conditions to coordinate growth and division. Our work shows that the strategy of signal integration, which was previously found in decision-making behaviors of animals, is adopted at the cellular level to reduce noise and minimize uncertainty.
View details for DOI 10.7554/eLife.03977
View details for Web of Science ID 000347918100003
View details for PubMedID 25590650
View details for PubMedCentralID PMC4378612