Stanford Advisors

All Publications

  • Diversity and functional landscapes in the microbiota of animals in the wild. Science (New York, N.Y.) Levin, D., Raab, N., Pinto, Y., Rothschild, D., Zanir, G., Godneva, A., Mellul, N., Futorian, D., Gal, D., Leviatan, S., Zeevi, D., Bachelet, I., Segal, E. 2021


    Animals in the wild are able to subsist on pathogen-infected and poisonous food and show immunity to various diseases. These may be due to their microbiota, yet we have a poor understanding of animal microbial diversity and function. We used metagenomics to analyze the gut microbiota of over 180 species in the wild, covering diverse classes, feeding behaviors, geographies, and traits. Using de novo metagenome assembly, we constructed and functionally annotated a database of over 5,000 genomes, comprising 1,209 bacterial species of which 75% are unknown. The microbial composition, diversity, and functional content exhibit associations with animal taxonomy, diet, activity, social structure and lifespan. We identify the gut microbiota of wild animals as a largely untapped resource for the discovery of therapeutics and biotechnology applications.

    View details for DOI 10.1126/science.abb5352

    View details for PubMedID 33766942