Professional Education

  • Bachelor of Science, National Taiwan University (2003)
  • Master of Science, National Taiwan University (2007)
  • Doctor of Philosophy, University College London (2012)

Stanford Advisors

  • Jun Ding, Postdoctoral Research Mentor

All Publications

  • Input- and Cell-Type-Specific Endocannabinoid-Dependent LTD in the Striatum CELL REPORTS Wu, Y., Kim, J., Tawfik, V. L., Lalchandani, R. R., Scherrer, G., Ding, J. B. 2015; 10 (1): 75-87


    Changes in basal ganglia plasticity at the corticostriatal and thalamostriatal levels are required for motor learning. Endocannabinoid-dependent long-term depression (eCB-LTD) is known to be a dominant form of synaptic plasticity expressed at these glutamatergic inputs; however, whether eCB-LTD can be induced at all inputs on all striatal neurons is still debatable. Using region-specific Cre mouse lines combined with optogenetic techniques, we directly investigated and distinguished between corticostriatal and thalamostriatal projections. We found that eCB-LTD was successfully induced at corticostriatal synapses, independent of postsynaptic striatal spiny projection neuron (SPN) subtype. Conversely, eCB-LTD was only nominally present at thalamostriatal synapses. This dichotomy was attributable to the minimal expression of cannabinoid type 1 (CB1) receptors on thalamostriatal terminals. Furthermore, coactivation of dopamine receptors on SPNs during LTD induction re-established SPN-subtype-dependent eCB-LTD. Altogether, our findings lay the groundwork for understanding corticostriatal and thalamostriatal synaptic plasticity and for striatal eCB-LTD in motor learning.

    View details for DOI 10.1016/j.celrep.2014.12.005

    View details for Web of Science ID 000347465600008

    View details for PubMedID 25543142